RPR1 - Overview: Respiratory Profile, Region 1, North Atlantic (CT, MA, ME, NJ, NH, NY, PA, RI, VT), Serum

Assessing sensitization to various inhalant allergens commonly found in the North Atlantic region including Connecticut, Maryland, Maine, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, and Vermont Defining the allergen...

PT217 - Overview: Phospho-Tau 217, Plasma

Evaluation of individuals, aged 50 years and older, presenting with cognitive impairment who are being assessed for Alzheimer disease and other causes of cognitive decline This test is not intended as a screening test for Alzheimer...

INAB - Overview: Insulin Antibodies, Serum

Predicting the future development of type 1 diabetes in asymptomatic children, adolescents, and young adults, when used in conjunction with family history, human leukocyte antigen-typing, and other autoantibodies, including glutamic acid...

ALPI - Overview: Alkaline Phosphatase Isoenzymes, Serum

Aid in the diagnosis and treatment of liver, bone, intestinal, and parathyroid diseases Determining the tissue source of increased alkaline phosphatase (ALP) activity in serum Differentiating between liver and bone sources of elevated...

DBS1 - Overview: Diabetes Mellitus Type 1 Evaluation, Serum

Distinguishing type 1 from type 2 diabetes mellitus Identifying individuals at risk of type 1 diabetes (including high-risk relatives of patients with diabetes) Predicting future insulin requirement treatment in patients with adult-onset...

LDLD - Overview: Low-Density Lipoprotein (LDL) Cholesterol, Beta-Quantification, Serum

Evaluation of cardiovascular risk Verification of estimated low-density lipoprotein cholesterol (LDL-C) in patients with hypertriglyceridemia or extremely low LDL-C Diagnosis of familial hypobetalipoproteinemia and abetalipoproteinemia

ALKP - Overview: Alkaline Phosphatase, Total and Isoenzymes, Serum

Aid in the diagnosis and treatment of liver, bone, intestinal, and parathyroid diseases Determining the tissue source of increased alkaline phosphatase (ALP) activity in serum Differentiating between liver and bone sources of elevated ALP

MPS1Z - Overview: Hurler Syndrome, Full Gene Analysis, Varies

Identifying variants within the IDUA gene Confirmation of a diagnosis of mucopolysaccharidosis type I (MPS-I) Carrier testing when there is a family history of MPS- I, but disease-causing variants have not been previously identified

RBCS - Overview: Relative B-Cell Subset Analysis Percentage, Blood

Screening for humoral or combined immunodeficiencies, including common variable immunodeficiency, hyper IgM syndrome, among others, where B-cell subset distribution information is desired Assessing B-cell subset reconstitution after...

UBT - Overview: Helicobacter pylori Breath Test

Diagnostic testing for Helicobacter pylori infection in patients suspected to have active H pylori infection Monitoring response to therapy This test is not appropriate for asymptomatic people.

QUAD1 - Overview: Quad Screen (Second Trimester) Maternal, Serum

Prenatal screening for open neural tube defect (alpha-fetoprotein only), trisomy 21 (alpha-fetoprotein, human chorionic gonadotropin, estriol, and inhibin A) and trisomy 18 (alpha-fetoprotein, human chorionic gonadotropin, and estriol)

LMPP - Overview: Lipoprotein Metabolism Profile, Serum

Diagnosing dyslipoproteinemia Quantifying cholesterol and triglycerides in very-low-density lipoprotein, low-density lipoprotein (LDL), high-density lipoproteins (HDL), and chylomicrons Identifying lipoprotein-X Classifying...

DPYDZ - Overview: Dihydropyrimidine Dehydrogenase, DPYD Full Gene Sequencing, Varies

Identifying individuals at increased risk of toxicity when considering 5-fluorouracil and capecitabine chemotherapy treatment Identifying common and rare variants associated with decreased or absent dihydropyrimidine dehydrogenase (DPD)...

NFLP - Overview: Neurofilament Light Chain, Plasma

Assessing neuronal damage related to various neurodegenerative diseases

DPYDQ - Overview: Dihydropyrimidine Dehydrogenase Genotype, Varies

Identifying individuals with genetic variants in DPYD who are at increased risk of toxicity when prescribed 5-fluorouracil (5-FU) or capecitabine chemotherapy treatment

LITH - Overview: Lithium, Serum

Monitoring therapy of patients with bipolar disorders, including recurrent episodes of mania and depression Evaluating lithium toxicity

FHLCG - Overview: Immunoglobulin G (IgG) Heavy and Light Chain (HLC) Pairs, Kappa and Lambda with Ratio

Heavy and light chain pair quantitation may be useful for: 1. Distinguishing between broadly migrating monoclonal proteins and restricted polyclonal immunoglobulin patterns on serum electrophoresis. 2. Quantitating monoclonal IgG proteins...

CHOL - Overview: Cholesterol, Total, Serum

Evaluation of cardiovascular risk

CLDL1 - Overview: Cholesterol, Low-Density Lipoprotein (LDL), Calculated, Serum

Calculation of low-density lipoprotein cholesterol using total cholesterol, non-high-density lipoprotein (HDL) cholesterol, HDL cholesterol, and triglyceride concentrations Managing atherosclerotic cardiovascular disease risk

TRIGC - Overview: Triglycerides, CDC, Serum

Measurement of triglycerides as part of lipoprotein profiling

CD3I - Overview: CD3 Immunostain, Technical Component Only

Demonstrating T-cell lineage

HDCH - Overview: Cholesterol, High-Density Lipoprotein (HDL), Serum

Measurement of serum high-density lipoprotein concentrations for managing atherosclerotic cardiovascular disease risk

CA153 - Overview: Cancer Antigen 15-3 (CA 15-3), Serum

Managing breast cancer patients when used in conjunction with clinical information and other diagnostic procedures Serial testing to assist in early detection of disease recurrence in previously treated stage II and III breast cancer...

PTNT - Overview: Prothrombin G20210A Mutation, Blood

Patients with clinically suspected thrombophilia Determination of the duration of anticoagulation therapy of venous thromboembolism patients Screening for women contemplating hormone therapy

PTH - Overview: Parathyroid Hormone (PTH) Immunostain, Technical Component Only

Identification of parathyroid glands

FUSI - Overview: FUS Immunostain, Technical Component Only

Identification of frontotemporal lobar dementia

MYOD1 - Overview: Myogenic Differentiation Antigen 1 (MYOD1) Immunostain, Technical Component Only

Marker of skeletal muscle differentiation

MYOGE - Overview: Myogenin Immunostain, Technical Component Only

Marker of skeletal muscle differentiation

TRIG1 - Overview: Triglycerides, Serum

Managing atherosclerotic cardiovascular disease risk

ACHE_ - Overview: Acetylcholinesterase, Amniotic Fluid

Diagnosing open neural tube defects and, to a lesser degree, ventral wall defects

BPAB - Overview: Bullous Pemphigoid, BP180 and BP230, IgG Antibodies, Serum

Initial screening test in the diagnosis of bullous pemphigoid and its variants Complementing the standard serum test of indirect immunofluorescence utilizing primate esophagus substrate and primate salt-split skin substrate (CIFS /...

ROM - Overview: Measles (Rubeola) Antibodies, IgM, Serum

Determining acute-phase infection with rubeola (measles) virus using IgM antibody testing Aiding in the identification of nonimmune individuals through IgM antibody testing

BALLM - Overview: B-Cell Lymphoblastic Leukemia Monitoring, Minimal Residual Disease Detection, Flow Cytometry, Varies

Aids in monitoring a previously confirmed diagnosis of B-cell acute lymphoblastic leukemia

GBAW - Overview: Beta-Glucosidase, Leukocytes

Diagnosis of Gaucher disease This test is not intended for carrier detection.

XL2T - Overview: FOXL2 Mutation Analysis, Next-Generation Sequencing, Tumor

Assisting in the clinical diagnosis of adult granulosa cell tumor by assessing gene targets with in the FOXL2 gene

LPSC1 - Overview: Lipid Panel, Serum

Managing atherosclerotic cardiovascular disease risk using serum specimens

CRMP1 - Overview: Cardiovascular Risk Marker Panel, Serum

Assessment for risk of developing cardiovascular disease, major adverse cardiovascular events, or ischemic cerebrovascular events

PTNZ - Overview: PTEN Hamartoma Tumor Syndrome, PTEN Full Gene Analysis, Varies

Evaluating patients with a personal or family history suggestive of PTEN hamartoma tumor syndrome (PHTS) Establishing a diagnosis of PHTS allowing for targeted cancer surveillance based on associated risks Identifying variants within...

BCELL - Overview: B-Cell and Antibody Deficiency Gene Panel, Varies

Providing a comprehensive genetic evaluation for patients with a personal or family history suggestive of an inherited primary B-cell disorder or humoral immunodeficiency Establishing a diagnosis of a primary B-cell disorder or humoral...

XCP - Overview: Hereditary Expanded Cancer Panel, Varies

Evaluating hereditary cancer in patients with a personal or family history suggestive of a hereditary cancer syndrome using a panel of 87 genes Establishing a diagnosis of a hereditary cancer syndrome allowing for targeted cancer...

GNPRS - Overview: Protein S Deficiency, PROS1 Gene, Next-Generation Sequencing, Varies

Evaluating protein S deficiency in patients with a personal or family history suggestive of this hereditary thrombophilia Confirming a diagnosis of autosomal dominant protein S deficiency with the identification of a known or suspected...

COMCP - Overview: Hereditary Common Cancer Panel, Varies

Evaluating hereditary cancer for patients with a personal or family history suggestive of a hereditary cancer syndrome using a panel of 36 genes Establishing a diagnosis of a hereditary cancer syndrome allowing for targeted cancer...

IABCS - Overview: B-Cell Phenotyping Profile for Immunodeficiency and Immune Competence Assessment, Blood

Screening for common variable immunodeficiency and hyper-IgM syndromes Assessing B-cell subset reconstitution after stem cell or bone marrow transplant Assessing response to B-cell-depleting immunotherapy This test is not indicated...

C2AD2 - Overview: PrecivityAD2, Plasma

Assisting in the evaluation of adult patients, aged 55 years and older, with signs or symptoms of mild cognitive impairment or dementia who are being assessed for Alzheimer disease and other causes of cognitive decline This is not...

HCCDD - Overview: Hepatitis C Virus Antibody, Cadaveric or Hemolyzed Specimens, Symptomatic, Serum

Diagnosis of hepatitis C virus (HCV) infection in cadaveric or hemolyzed serum specimens from symptomatic patients with or without risk factors for HCV infection This test is not intended for screening blood, cell, or tissue donors. This...

PMAOG - Overview: Postmortem Aortopathy Gene Panel, Tissue

Providing a comprehensive postmortem genetic evaluation in the setting of a sudden death attributed to thoracic aortic dissection or with a personal or family history suggestive of Marfan syndrome, Loeys-Dietz syndrome, thoracic aortic...

HCCAD - Overview: Hepatitis C Virus Antibody Screen, Cadaveric or Hemolyzed Specimens, Asymptomatic, Serum

Screening cadaveric or hemolyzed serum specimens for hepatitis C virus (HCV) infection in asymptomatic individuals with or without risk factors for HCV infection Note: In accordance with National Coverage Determination guidance, this test...

APOEG - Overview: Apolipoprotein E Genotyping, Blood

Determining the specific apolipoprotein E (APOE) genotypes in individuals with type III hyperlipoproteinemia Determining the specific APOE genotypes that may increase risk for amyloid related imaging abnormalities in individuals being...

AD2AR - Overview: PrecivityAD2, Reflex to Apolipoprotein E, Plasma

Assisting in the evaluation of adult patients, aged 55 years and older, with signs or symptoms of mild cognitive impairment or dementia who are being assessed for Alzheimer disease and other causes of cognitive decline Determining APOE E4...

ADLTX - Overview: Adulterants Survey, Chain of Custody, Random, Urine

Assess the possible adulteration of a urine specimen submitted for drug of abuse testing Providing the urine creatinine concentration for normalization purposes Chain of custody is required whenever the results of testing could be used...