Identification of parathyroid glands
Test Id | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
IHTOI | IHC Initial, Tech Only | No | No |
IHTOA | IHC Additional, Tech Only | No | No |
Immunohistochemistry
PTH
ISPTHIHCTO
TECHONLY
This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.
Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.
Supplies: Immunostain Technical Only Envelope (T693)
Specimen Type: Tissue
Container/Tube: Immunostain Technical Only Envelope
Preferred: 2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick
Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block
1. Information on accessing digital images of immunohistochemical (IHC) stains and the manual requisition form can be accessed through this website: https://news.mayocliniclabs.com/ihc-stains/
2. Clients ordering stains using a manual requisition form will not have access to digital images.
3. Clients wishing to access digital images must place the order for IHC stains electronically. Information regarding digital imaging can be accessed through this website: https://news.mayocliniclabs.com/ihc-stains/#FAQ
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763)
-Renal Diagnostics Test Request (T830)
Wet/frozen tissue Cytology smears Nonformalin fixed tissue Nonparaffin embedded tissue Noncharged slides ProbeOn slides | Reject |
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
TECHONLY | Ambient (preferred) | ||
Refrigerated |
Identification of parathyroid glands
Parathyroid hormone staining is useful in identifying parathyroid glands in cases of hyperparathyroidism. Hyperproduction of parathyroid-like hormone may occur in association with lung tumors; such tumors may have reactivity with parathyroid hormone antibodies.
This test does not include pathologist interpretation, only technical performance of the stain. If interpretation is required, order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.
The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request; call 855-516-8404.
Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen dependent. Best practice is for paraffin sections to be cut within 6 weeks.
1. Matsushita H, Usui M, Hara Y, et al: Co-secretion of parathyroid hormone and parathyroid-hormone-related protein via a regulated pathway in human parathyroid adenoma cells. Am J Pathol. 1997 Mar;150(3):661-871
2. Oka T, Yoshioka T, Shrestha GR, et al: Immunohistochemical study of nodular hyperplastic parathyroid glands in patients with secondary hyperparathyroidism. Virchows Arch A Pathol Anat Histopathol. 1988;413(1):53-60
3. Wick MR, Ritter JH, Humphrey PA, Nappi O: Clear cell neoplasms of the endocrine system and thymus. Semin Diagn Pathol. 1997 Aug;14(3):183-202
4. Sass MR, Wewer Albrechtsen NJ, Pedersen J, et al: Secretion of parathyroid hormone may be coupled to insulin secretion in humans. Endocr Connect. 2020 Jul;9(7):747-754. doi: 10.1530/EC-20-0092
Immunohistochemistry on sections of paraffin-embedded tissue.(Unpublished Mayo method)
Monday through Friday
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.
88342-TC, primary
88341-TC, if additional IHC
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
PTH | Parathyroid Hormone IHC, Tech Only | Order only;no result |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
70856 | Parathyroid Hormone IHC, Tech Only | Bill only; no result |