MMAS - Overview: Methylmalonic Acid, Quantitative, Serum
Evaluating children with signs and symptoms of methylmalonic acidemia using serum specimens Evaluating individuals with signs and symptoms associated with a variety of causes of vitamin B12 (cobalamin) deficiency
AACYL - Overview: Aminoacylase-1 Deficiency, Urine
Follow-up quantitation of abnormal organic acid elevations of N-acetylated amino acids, in particular N-acetylalanine, N-acetylglycine, N-acetylmethionine, and N-acetylglutamic acid Diagnosis of individuals with aminoacylase-1...
WASQR - Overview: Alpha-Globin Gene Sequencing, Blood
Testing for nondeletional alpha thalassemia in a symptomatic individual Follow-up testing to an abnormal hemoglobin electrophoresis that identified an alpha-globin chain variant Evaluating for nondeletional alpha thalassemias in an...
APPI - Overview: Amyloid Precursor Protein (APP) Immunostain, Technical Component Only
Aids in the identification of amyloid precursor protein present in Alzheimer disease
ADV - Overview: Adenovirus Immunostain, Technical Component Only
Identification of adenovirus infection
ALP - Overview: Alkaline Phosphatase, Serum
Diagnosing and monitoring treatment of liver, bone, intestinal, and parathyroid diseases
BCOR - Overview: BCOR Immunostain, Technical Component Only
Aiding in the distinction of a subset of primitive round cell sarcomas with BCOR rearrangements from other Ewing/Ewing-like sarcomas
BVRNA - Overview: Bacterial Vaginosis, Nucleic Acid Amplification, Vaginal
Aid for diagnosis of bacterial vaginosis This test is not intended for use in medico-legal applications.
BRG1 - Overview: BRG1 (SMARCA4) Immunostain, Technical Component Only
Diagnosing ovarian small cell carcinoma of hypercalcemic type (SCCOHT)
FACTV - Overview: Coagulation Factor V Activity Assay, Plasma
Diagnosing congenital deficiencies (rare) of coagulation factor V Evaluating acquired deficiencies associated with liver disease, factor V inhibitors, myeloproliferative disorders, and intravascular coagulation and fibrinolysis...
NEUD1 - Overview: Neuronal Differentiation 1 (NeuroD1), Technical Component only
Subclassification of small cell lung carcinoma
SUDC - Overview: Sudden Cardiac Death Pathology Consultation
Identifying specific causes contributing to sudden cardiac death
C5B9 - Overview: SC5b-9 Level Terminal Complement Complex, Plasma
Detecting increased complement activation
TIBC - Overview: Total Iron Binding Capacity, Serum
Screening for chronic iron overload diseases, particularly hereditary hemochromatosis
SV40 - Overview: SV40 Immunostain, Technical Component Only
Identifying BK or JC polyomavirus
F_2 - Overview: Coagulation Factor II Activity Assay, Plasma
Diagnosing a congenital deficiency (rare) of coagulation factor II Evaluating acquired deficiencies associated with liver disease or vitamin K deficiency, oral anticoagulant therapy, and antibody-induced deficiencies (eg, in association...
PIK3B - Overview: Cell-Free DNA PIK3CA Test, Blood
Identification of hormone receptor positive and human epidermal growth factor receptor 2 negative (HR+/HER2-) advanced breast cancer tumors that may be eligible for treatment with targeted kinase inhibitor therapy (eg, alpelisib).
Aids in the diagnosis of epithelioid hemangioendotheliomas
CLZ - Overview: Clozapine, Serum
Monitoring patient compliance of clozapine treatment An aid to achieving desired serum levels
DIG - Overview: Digoxin, Serum
Monitoring digoxin therapy
EDN - Overview: Eosinophil Derived Neurotoxin, Serum
Evaluating patients suspected to have a condition associated with eosinophilia or hypereosinophilia Evaluating patients with elevated peripheral blood eosinophil counts Managing patients with elevated eosinophil-derived neurotoxin in the...
MELAN - Overview: Melan A (MART-1) Immunostain, Technical Component Only
Aids in the identification of melanoma
C3FX - Overview: C3 Complement, Functional, Serum
Diagnosis of C3 deficiency Investigation of a patient with undetectable total complement level
C2FXN - Overview: C2 Complement, Functional, Serum
Investigation of a patient with a low (absent) hemolytic complement
TRK - Overview: Tropomyosin Receptor Kinase (TRK) Immunostain, Technical Component Only
Helpful in the screening for neurotrophic tyrosine receptor kinase (NTRK) rearranged tumors
FRAG - Overview: Osmotic Fragility, Erythrocytes
Evaluating suspected hereditary spherocytosis-associated hemolytic anemia Confirming or detecting mild spherocytosis
HBELI - Overview: Hemoglobin Electrophoresis Interpretation
Interpretation for the results of hemoglobin electrophoresis Diagnosis and classification of hemoglobin disorders, including thalassemias and hemoglobin variants
NHEP - Overview: Hereditary Erythrocytosis Gene Panel, Next-Generation Sequencing, Varies
Evaluating an individual with JAK2-V617F negative erythrocytosis associated with lifelong sustained increased red blood cell (RBC) mass, elevated RBC count, hemoglobin, or hematocrit Providing an extensive genetic evaluation for patients...
GNMTC - Overview: Macro/Microthrombocytopenia Gene Panel, Next-Generation Sequencing, Varies
Evaluating hereditary macro- or microthrombocytopenia disorders in patients with a personal or family history suggestive of a hereditary macro- or microthrombocytopenia disorder Diagnosing hereditary macro- or microthrombocytopenia...
AHLP - Overview: AudioloGene Hearing Loss Panel, Varies
Establishing a diagnosis of a syndromic or nonsyndromic hereditary hearing loss disorder Identifying variants within genes known to be associated with hereditary hearing loss, allowing for predictive testing of at-risk family members
BCELL - Overview: B-Cell and Antibody Deficiency Gene Panel, Varies
Providing a comprehensive genetic evaluation for patients with a personal or family history suggestive of an inherited primary B-cell disorder or humoral immunodeficiency Establishing a diagnosis of a primary B-cell disorder or humoral...
EPPAN - Overview: Comprehensive Epilepsy With or Without Encephalopathy Gene Panel, Varies
Establishing a diagnosis of an epilepsy or seizure disorder associated with known causal genes Identifying disease-causing variants within genes known to be associated with inherited epilepsy or seizure disorders, allowing for predictive...
Evaluating congenital fibrinogen disorders (CFD) in patients with a personal or family history suggestive of a fibrinogen disorder Confirming a CFD diagnosis with the identification of known or suspected disease-causing alterations in the...
NEPHP - Overview: Comprehensive Nephrology Gene Panel, Varies
Providing a genetic evaluation for patients with a personal or family history suggestive of hereditary kidney disease Establishing a diagnosis for a variety of hereditary kidney conditions including focal segmental glomerulosclerosis,...
GNSPD - Overview: Platelet Storage Pool Deficiency Gene Panel, Next-Generation Sequencing, Varies
Evaluating hereditary platelet storage pool deficiencies in patients with a personal or family history suggestive of a hereditary platelet storage pool deficiency Diagnosing hereditary platelet storage pool deficiencies for patients in...
PRL - Overview: Prolactin, Serum
Aiding in evaluation of pituitary tumors, amenorrhea, galactorrhea, infertility, and hypogonadism Monitoring therapy of prolactin-producing tumors
PCAG - Overview: Protein C Antigen, Plasma
Differentiating congenital type I protein C deficiency from type II deficiency Evaluating the significance of decreased functional protein C, especially when decreased protein C activity might be congenital rather than acquired (eg, due...
PIK3T - Overview: PIK3CA Mutation Analysis, Tumor
Identification of hormone receptor positive and human epidermal growth factor receptor 2 negative (HR+/HER2-) advanced breast cancer tumors that may be eligible for treatment with targeted kinase inhibitor therapy (eg, alpelisib).
PCHE1 - Overview: Pseudocholinesterase, Total, Serum
Monitoring exposure to organophosphorus insecticides and herbicides Monitoring patients with liver disease, particularly those undergoing liver transplantation Identifying patients who are homozygous or heterozygous for an atypical gene...
TOXB - Overview: Toxoplasma gondii, Molecular Detection, PCR, Blood
Supporting the diagnosis of active toxoplasmosis, particularly in immunocompromised individuals
VWFMP - Overview: von Willebrand Factor Multimer Analysis, Plasma
As a reflex component of several coagulation consultation unit codes, when indicated When results of complementary laboratory tests are abnormally low or discordant (eg, F8A / Coagulation Factor VIII Activity Assay, Plasma; VWACT / von...
SMAS - Overview: Smooth Muscle Antibody Screen, Serum
Evaluation of patients with hepatitis of unknown origin associated with hypergammaglobulinemia and/or abnormal liver enzymes
BIVAL - Overview: Bivalirudin, Ecarin, Plasma
Monitoring of bivalirudin therapy for patients with prolonged baseline activated partial thromboplastin time
ROM - Overview: Measles (Rubeola) Antibodies, IgM, Serum
Determining acute-phase infection with rubeola (measles) virus using IgM antibody testing Aiding in the identification of nonimmune individuals through IgM antibody testing
PRSSZ - Overview: PRSS1 Gene, Full Gene Analysis, Varies
Confirmation of suspected clinical diagnosis of hereditary pancreatitis (HP) in patients with chronic pancreatitis Identification of familial PRSSI mutation to allow for predictive and diagnostic testing in family members
RIVAR - Overview: Rivaroxaban, Anti-Xa, Plasma
Measuring rivaroxaban concentration in selected clinical situations (eg, kidney insufficiency, assessment of compliance, periprocedural measurement of drug concentration, suspected overdose, advanced age, and extremes of body weight)
RISA - Overview: Risankizumab, Serum
Assessing the response to risankizumab therapy Assessing the need for dose escalation Evaluating potential changes or discontinuation of therapy Monitoring patients who need to be above a certain risankizumab concentration to improve the...
OXU - Overview: Oxalate, 24 Hour, Urine
Monitoring therapy for kidney stones using 24-hour urine collections Identifying increased urinary oxalate as a risk factor for stone formation Diagnosis of primary or secondary hyperoxaluria
IGM - Overview: Immunoglobulin M (IgM), Serum
Detecting or monitoring of IgM monoclonal gammopathies and IgM-related immune deficiencies
IGAS - Overview: IgA Subclasses, Serum
Investigation of immune deficiency due to IgA2 deficiency Evaluating patients with anaphylactic transfusion reactions
Mayo Clinic Staff Members Honored in ASCP's "40 under Forty" - Insights
Clinical Pathology (ASCP) has announced the 2017 “40 under Forty” honorees. Each year, the Selection Committee identifies 40 ASCP members under the age of 40 who are recognized for being future pathology and...
D., named to Business Insider's list of 30 under 40 working to transform health care - Insights
Since the pandemic hit, she's spent a great deal of time vetting antibody tests and has set up a COVID-19 testing program at Mayo Clinic.
Mayo Clinic Laboratory and Pathology Research Roundup: March 13 - Insights
evolution of giant cell arteritis with a prospective study of follow-up temporal artery biopsies in 40 treated patients....
High School Students Experience Laboratory Professional Careers - Insights
Last month in Rochester, the Mayo Clinic School of Health Sciences welcomed 40 Minnesota high school juniors and seniors to tour various areas of the Mayo Clinic campus as a part of this year’s Career...
Yuma Regional Medical Center: Changing perceptions and powering growth - Insights
leaders, resulting in a changed perception of the laboratory’s ability to drive profitability and a $40 million capital investment in laboratory infrastructure....