BIWB - Overview: Bismuth, Blood
Determining bismuth toxicity
DESPR - Overview: Desipramine, Serum
Monitoring serum concentration of desipramine during therapy Evaluating potential desipramine toxicity May aid in evaluating patient compliance
RCVBS - Overview: Recoverin-IgG Antibody, Immunoblot, Serum
Evaluating patients with suspected paraneoplastic retinopathy accompanying small cell carcinoma
CHLGP - Overview: Cholestasis Gene Panel, Varies
Establishing a molecular diagnosis for patients with monogenic cholestasis Identifying variants within genes known to be associated with primary, monogenic cholestasis, allowing for predictive testing of at-risk family members This panel...
6MAMM - Overview: 6-Monoacetylmorphine (6-MAM), Confirmation, Meconium
Detection of in utero heroin exposure up to 5 months before birth
PARID - Overview: Parasite Identification, Varies
Gross identification of parasites (eg, worms) and arthropods (eg, ticks, bed bugs, lice, mites) Detecting or eliminating the suspicion of parasitic infection by identifying suspect material passed in stool or found on the body Supporting...
Identification of herpes simplex virus I and II infection
Determining overexpression of HER2 protein of gastric and esophageal adenocarcinoma in formalin-fixed, paraffin-embedded tissue sections (no reflex to FISH testing)
HMNA - Overview: Heavy Metals, Nails
Detection of nonacute arsenic, mercury, and lead exposure
IMIPR - Overview: Imipramine and Desipramine, Serum
Monitoring imipramine and desipramine concentrations during therapy Evaluating potential imipramine and desipramine toxicity May aid in evaluating patient compliance
GLUCG - Overview: Glucagon Immunostain, Technical Component Only
Aiding in the study of islet-cell tumors and some endocrine tumors of the gastrointestinal tract
KRT19 - Overview: Keratin 19 (KRT19) Immunostain, Technical Component Only
Aids in the identification of cells expressing low molecular weight cytokeratin (KRT19)
ALKD5 - Overview: Anaplastic Lymphoma Kinase (ALK[D5F3]) Immunostain, Technical Component Only
Identification of anaplastic lymphoma kinase overexpression Diagnosis of lung adenocarcinoma and inflammatory myofibroblastic tumor
B2M - Overview: Beta-2-Microglobulin, Serum
Prognosis assessment of multiple myeloma Evaluation of renal tubular disorders
BFBL - Overview: Bilirubin, Body Fluid
Evaluating peritoneal fluid or abdominal drain fluid as a screening test for bile leakage May aid in the distinction between a transudative and an exudative pleural effusion
NAPSN - Overview: Napsin A Immunostain, Technical Component Only
Identification of primary lung adenocarcinoma
TIBC - Overview: Total Iron Binding Capacity, Serum
Screening for chronic iron overload diseases, particularly hereditary hemochromatosis
TPIT - Overview: T-PIT Immunostain, Technical Component Only
Diagnosis of corticotroph, silent corticotroph, and null cell adenomas of the pituitary
CD138 - Overview: CD138 (Syndecan) Immunostain, Technical Component Only
Marker of plasma cells and squamous epithelial cells
PTEM - Overview: Platelet Transmission Electron Microscopic Study, Whole Blood
Diagnosing platelet disorders
CHOU - Overview: Carbohydrate, Urine
Screening for conditions associated with increased excretion of carbohydrates, including inborn errors of fructose and galactose metabolism. This test is not recommended as a follow up test for abnormal newborn screening for galactosemia.
FOXP1 - Overview: FOXP1 Immunostain, Technical Component Only
Classification of lymphomas
Qualitative detection of human T-cell lymphotropic virus types I and II (HTLV-I and HTLV-II)-specific antibodies with confirmation and differentiation between HTLV-I and HTLV-II infection This test should not be used to screen blood, human...
APCRV - Overview: Activated Protein C Resistance V (APCRV), Plasma
Evaluation of patients with incident or recurrent venous thromboembolism (VTE) Evaluation of individuals with a family history of VTE
CMVQN - Overview: Cytomegalovirus (CMV) DNA Detection and Quantification by Real-Time PCR, Plasma
Detection and quantification of cytomegalovirus (CMV) viremia Monitoring CMV disease progression and response to antiviral therapy
STL - Overview: Enteric Pathogens Culture, Feces
Determining whether a bacterial enteric pathogen is the cause of diarrhea May be helpful in identifying the source of the infectious agent (eg, dairy products, poultry, water, or meat) This test is generally not useful for patients...
MMPGM - Overview: Mumps Virus Antibody, IgM and IgG, Serum
Diagnosis of mumps virus infection Determination of postimmunization immune response of individuals to the mumps vaccine Documentation of previous infection with mumps virus in an individual with no previous record of immunization to...
MPS4W - Overview: Mucopolysaccharidosis IV Enzyme Panel, Leukocytes
Supporting the biochemical diagnosis of mucopolysaccharidosis type IVA and IVB in whole blood specimens This test is not useful for carrier detection.
C2NAD - Overview: PrecivityAD, Plasma
Assisting in the evaluation of adult patients, aged 55 years and older, with signs or symptoms of mild cognitive impairment or dementia who are being assessed for Alzheimer disease and other causes of cognitive decline This is not intended...
ANPAT - Overview: Anatomic Pathology Consultation, Wet Tissue
Obtaining a rapid, expert opinion on unprocessed specimens (lung tissue for immunofluorescence, cardiac biopsies, enucleated eye specimens, iris, conjunctiva, cornea, and other small eye biopsies) referred by a pathologist This test is not...
C9ORF - Overview: C9orf72 Hexanucleotide Repeat, Molecular Analysis, Varies
Molecular confirmation of clinically suspected cases of c9FTD/ALS, frontotemporal dementia (FTD), or amyotrophic lateral sclerosis (ALS) Presymptomatic testing for individuals with a family history of c9FTD/ALS and a documented expansion...
Confirmation of a clinical diagnosis of Duchenne muscular dystrophy (DMD) or Becker muscular dystrophy (BMD) Distinguishing DMD from BMD in some cases, based on the type of deletion detected (allows for better prediction of...
DHCRZ - Overview: Smith Lemli Opitz Syndrome, DHCR7 Gene, Full Gene Analysis, Varies
Follow up for abnormal biochemical results suggestive of Smith-Lemli-Opitz syndrome Establishing a molecular diagnosis for patients with Smith-Lemli-Opitz syndrome Identifying alterations within DHCR7 allowing for predictive testing of...
GNHMB - Overview: Hemophilia B, F9 Gene, Next-Generation Sequencing, Varies
Confirming a clinical diagnosis of hemophilia B in affected male patients with the identification of a disease-causing variant in the F9 gene Determining the disease-causing alteration within the F9 gene to delineate the underlying...
LUCHM - Overview: LiquidHALLMARK ctDNA and ctRNA
As an alternative to invasive tissue biopsies to assist in tumor profiling for diagnosis, predicting prognosis, and identifying targeted therapies for the treatment and management of patients with a solid tumor This test is not useful for...
Evaluation of pediatric bone marrow and peripheral blood specimens by fluorescence in situ hybridization probe analysis for classic rearrangements and chromosomal copy number changes associated with T-cell acute lymphoblastic leukemia in...
GAAZ - Overview: Pompe Disease, Full Gene Analysis, Varies
Confirmation of diagnosis of Pompe disease (as a follow-up to biochemical analyses)
HBAB - Overview: Hepatitis B Virus Surface Antibody, Qualitative/Quantitative, Serum
Identifying previous exposure to hepatitis B virus Determining adequate immunity from hepatitis B vaccination
HBBSN - Overview: Hepatitis B Virus Surface Antibody Screen, Qualitative/Quantitative, Serum
Identifying previous exposure to hepatitis B virus
APCRR - Overview: Activated Protein C Resistance V, with Reflex to Factor V Leiden, Blood and Plasma
Evaluating patients with incident or recurrent venous thromboembolism (VTE) Evaluating individuals with a family history of VTE
HBABP - Overview: Hepatitis B Virus Surface Antibody Prenatal, Qualitative/Quantitative, Serum
Identifying previous exposure to hepatitis B virus in pregnant individuals Determining adequate immunity from hepatitis B vaccination during pregnancy
PKUBS - Overview: Phenylalanine and Tyrosine, Blood Spot
Monitoring effectiveness of therapy in patients with hyperphenylalaninemia This test is not sufficient for follow-up for abnormal newborn screening results or for establishing a diagnosis of a specific cause of hyperphenylalaninemia
MAMMX - Overview: 6-Monoacetylmorphine (6-MAM) Confirmation, Chain of Custody, Meconium
Detecting in utero heroin exposure up to 5 months before birth Chain of custody is required whenever the results of testing could be used in a court of law. Its purpose is to protect the rights of the individual contributing the specimen...
Detection of RUNX1-RUNX1T1 gene fusion in acute myeloid leukemia patients at the time of diagnosis Minimal residual disease monitoring during the clinical and therapeutic course of these patients
FRTUP - Overview: Free Thyroxine Index (FTI), Serum
Estimating the amount of circulating free thyroxine (free thyroxine index) using the total thyroxine and thyroid binding capacity (T-uptake)
KRASP - Overview: KRAS Somatic Mutation Analysis, Tumor
Detecting molecular markers associated with response or resistance to specific cancer
Detecting Mycoplasma genitalium in cases of suspected infection in peritoneal fluid or prostatic secretion (VBIII) fluid/urine This test is not intended for use in medico-legal applications.
ADVQU - Overview: Adenovirus DNA Detection and Quantification, Plasma
Aiding in the diagnosis of disseminated adenovirus infections in at-risk individuals Measuring adenoviral load in plasma to monitor disease progression and antiviral response in individuals with disseminated infection
ALLOI - Overview: Allo-isoleucine, Blood Spot
Evaluation of newborn screening specimens that test positive for branched-chain amino acids elevations Follow-up of patients with maple syrup urine disease
OAU - Overview: Organic Acids Screen, Random, Urine
Diagnosis of inborn errors of metabolism
Mayo Clinic Ranked No. 1 Hospital Nationwide by U.S. News & World Report - Insights
Report’s 29th annual "Best Hospitals Honor Roll" published online on August 14. Mayo Clinic also ranked No. 1 in more specialties than any other hospital in the country....
NELL-1 [Test in Focus] - Insights
D., discusses how Mayo Clinic Laboratories’ new immunohistochemistry test for the detection of NELL-1 antigen, a biomarker for membranous nephropathy found in 10% to 15% of patients, provides diagnostic...
Looking Back on Clinical Chemistry 1 - Insights
in the Mayo Clinic Medical Laboratory Science program, takes a look back on her Clinical Chemistry 1 course....
Detection of (1→3)-𝝱-D-glucan as a Marker of Invasive Fungal Disease - Insights
In this month’s “Hot Topic,” Elitza Theel, Ph.D., will discuss the detection of (1→3)-β-D-glucan (BDG) in serum as a biomarker for the presence of invasive fungal infections....
Orexin-A/Hypocretin-1 for the Diagnosis of Type 1 Narcolepsy [Test in Focus] - Insights
test to perform as well as to interpret. The orexin-A/hypocretin-1 test is a sensitive and specific alternative to the MSLT to diagnose type 1 narcolepsy....