Confirming the diagnosis of dermatofibrosarcoma protuberans (DFSP)/giant cell fibroblastoma (GCF) and excluding other spindle neoplasms that closely simulate the DFSP histology, including dermatofibroma (benign fibrous histiocytoma),...
USPF - Overview: USP6 (17p13), Aneurysmal Bone Cyst and Nodular Fasciitis, FISH, Tissue
Supporting the diagnosis of aneurysmal bone cyst or nodular fasciitis
HEMB - Overview: Hemoglobin (Hb) Immunostain, Technical Component Only
Identification of red blood cells and red blood cell precursors
ESR1T - Overview: ESR1 Mutation Analysis, Next-Generation Sequencing, Tumor
Assisting in the clinical management of patients with metastatic breast cancer by identifying tumors with evolving resistance to endocrine therapy Stratifying prognosis of metastatic breast cancer
MCMLN - Overview: MayoComplete Melanoma Panel, Next-Generation Sequencing, Tumor
Determining if patients will respond to targeted therapy Assessing microsatellite instability for immunotherapy decisions
GLIOF - Overview: 1p/19q Deletion in Gliomas, FISH, Tissue
Aids in diagnosing oligodendroglioma tumors and predicting the response of an oligodendroglioma to therapy May be useful in tumors with a complex "hybrid" morphology requiring differentiation from pure astrocytomas to support the presence...
PRKAF - Overview: Fibrolamellar Carcinoma, 19p13.1 (PRKACA) Rearrangement, FISH, Tissue
Aid in the diagnosis of identifying PRKACA gene rearrangements of patients with fibrolamellar carcinoma
TBSP - Overview: Mycobacterium tuberculosis Complex Species Identification, PCR, Varies
Determining the species of a Mycobacterium tuberculosis complex culture isolate
PIK3T - Overview: PIK3CA Mutation Analysis, Tumor
Identification of hormone receptor positive and human epidermal growth factor receptor 2 negative (HR+/HER2-) advanced breast cancer tumors that may be eligible for treatment with targeted kinase inhibitor therapy (eg, alpelisib).
PPFE - Overview: Protoporphyrins, Fractionation, Whole Blood
Evaluating patients with possible diagnoses of erythropoietic protoporphyria or X-linked dominant protoporphyria Establishing a biochemical diagnosis of erythropoietic protoporphyria and X-linked dominant protoporphyria
JAKXM - Overview: JAK2 Exon 12 and Other Non-V617F Mutation Detection, Bone Marrow
Second-order testing to aid in the distinction between a reactive cytosis and a myeloproliferative neoplasm, particularly when a diagnosis of polycythemia is being entertained; for use with bone marrow specimens
GCTF - Overview: Germ Cell Tumor (GCT), Isochromosome 12p, FISH, Tissue
Supporting the diagnosis of germ cell tumors when used conjunction with an anatomic pathology consultation
NGSFX - Overview: Reanalysis of Acute Myeloid Leukemia 4- or 11- Gene Panels, Additional Genes
Comprehensive reanalysis of a larger set of genes/gene regions when a more targeted gene panel was previously performed in this laboratory Evaluation of known or suspected hematologic neoplasms, specifically of myeloid origin (eg, acute...
VLTU - Overview: Volatile Screen, Random, Urine
Detecting the presence of acetone, methanol, isopropanol, or ethanol in urine with subsequent quantitation
MESOP - Overview: Mesothelioma Panel (WT1/KRT5/TTF1/pCEA) Immunostain, Technical Component Only
Differentiation of mesothelioma and non-small cell lung cancer
HBME - Overview: Mesothelial Cell (HBME-1) Immunostain, Technical Component Only
Classification of thyroid carcinomas
PTRIP - Overview: Prostate Triple (P63/KRT/P504S), Technical Component Only
Aiding in the identification of high-grade prostatic intraepithelial neoplasia and prostate cancer
VLTS - Overview: Volatile Screen, Serum
Detection and quantitation of acetone, methanol, isopropanol, and ethanol in serum Quantification of the concentration of ethanol in serum correlates with degree of intoxication Evaluation of toxicity to the measured volatile substances
LCCA - Overview: Identification, Candida auris, Rapid PCR (Bill Only)
Identification, Candida auris, Rapid PCR (Bill Only)
LCCI - Overview: Ident Rapid PCR Coccidioides (Bill Only)
Ident Rapid PCR Coccidioides (Bill Only)
EWSF - Overview: Ewing Sarcoma, 22q12 (EWSR1) Rearrangement, FISH, Tissue
Detection of EWSR1 rearrangements irrespective of the EWSR1 fusion partner gene Supporting the diagnosis of many neoplasms including, but not limited to, Ewing sarcoma, extraskeletal myxoid chondrosarcoma, desmoplastic small round cell...
IMTF - Overview: Inflammatory Myofibroblastic Tumors (IMT), 2p23 (ALK) Rearrangement, FISH, Tissue
Supporting the diagnosis of inflammatory myofibroblastic tumors when used conjunction with an anatomic pathology consultation
EOSMF - Overview: Chronic Eosinophilia, Specified FISH, Varies
Detecting a neoplastic clone associated with the common chromosome abnormalities seen in patients with myeloid/lymphoid neoplasms with eosinophilia and gene rearrangement (including PDGFRA, PDGFRB, FGFR1, JAK2, and ABL1) using specified...
IDHT - Overview: IDH1 and IDH2 Mutation Analyses, Next-Generation Sequencing, Tumor
Identifying specific mutations within the IDH1 and IDH2 genes that assist in tumor diagnosis/classification and predict response to targeted therapy
IHTOA - Overview: IHC Additional, Tech Only (Bill Only)
IHC Additional, Tech Only (Bill Only)
NGAML - Overview: MayoComplete Acute Myeloid Leukemia, 11-Gene Panel, Varies
Evaluation of acute myeloid leukemia using a focused 11-gene panel at the time of diagnosis, or possibly at the time of relapsed/refractory disease, to help guide classification and possible therapeutic approaches
LCMSP - Overview: Microsporidia species, Molecular Detection, PCR, Varies
Detecting Enterocytozoon bieneusi and Encephalitozoon species in fecal and urine specimens to support the clinical diagnosis of microsporidiosis
CD2B - Overview: CD2 Immunostain, Bone Marrow, Technical Component Only
Determining T-cell lineage
C19BM - Overview: CD19 Immunostain, Bone Marrow, Technical Component Only
Identification of normal and neoplastic B cells
Characterizing neoplasms of cytotoxic T cells or natural killer cells
IHTOI - Overview: IHC Initial, Tech Only (Bill Only)
IHC Initial, Tech Only (Bill Only)
Supporting the diagnosis of alveolar rhabdomyosarcomas when used in conjunction with an anatomic pathology consultation
CEE20 - Overview: CD20 Cell Expression Evaluation, Varies
Detecting cell-surface antigens on malignant cells that are potential therapeutic antibody targets, specifically CD20 Determining the eligibility of patients for monoclonal antibody therapies Monitoring response to the therapeutic...
CEE49 - Overview: CD49d Cell Expression Evaluation, Varies
Detecting cell-surface antigens on malignant cells that are potential therapeutic antibody targets, specifically CD49d Determining the eligibility of patients for monoclonal antibody therapies Monitoring response to the therapeutic...
CEE52 - Overview: CD52 Cell Expression Evaluation, Varies
Detecting cell-surface antigens on malignant cells that are potential therapeutic antibody targets, specifically CD52 Determining the eligibility of patients for monoclonal antibody therapies Monitoring response to the therapeutic...
F5DNA - Overview: Factor V Leiden (R506Q) Mutation, Blood
Patients with clinically suspected thrombophilia and: 1. Activated protein C (APC)-resistance either proven or suspected by a low or borderline APC-resistance ratio or 2. A family history of factor V Leiden
THIO - Overview: Thiopurine Metabolites, Whole Blood
Aids physicians in dose adjustments, minimizing dose-dependent toxicity, and monitoring compliance of thiopurine drug therapy
CIMRP - Overview: Coccidioides immitis/posadasii, Molecular Detection, PCR, Varies
Rapid detection of Coccidioides DNA, preferred method An aid in diagnosing coccidioidomycosis
Diagnosing syphilis
Evaluation of acute myeloid leukemia using a focused 4-gene panel at the time of diagnosis, or possibly relapsed or refractory disease, to help guide possible therapeutic approaches
TGOGF - Overview: TGFBR3 (1p22), OGA (10q24) Rearrangement, FISH, Tissue
Supporting the diagnosis of pleomorphic hyalinizing angiectatic tumor, or hemosiderotic fibrolipomatous tumors associated with rearrangement of the OGA and/or TGFBR3 gene when used in conjunction with an anatomic pathology consultation
KCSFP - Overview: Immunoglobulin Kappa Free Light Chain, Spinal Fluid
Diagnosis of multiple sclerosis and other demyelinating conditions
DDITF - Overview: Myxoid/Round Cell Liposarcoma, 12q13 (DDIT3 or CHOP) Rearrangement, FISH, Tissue
Aiding in the diagnosis of myxoid/round cell liposarcoma by detecting a neoplastic clone associated with gene rearrangement involving the DDIT3 (CHOP) gene region at 12q13
ATRX - Overview: ATRX Immunostain, Technical Component Only
Distinguishing differentiated from undifferentiated neoplasms
ALKOT - Overview: Anaplastic Lymphoma Kinase (ALK [OTI1A4]) Immunostain, Technical Component Only
Identification of anaplastic lymphoma kinase overexpression Diagnosis of inflammatory myofibroblastic tumor and anaplastic large cell lymphoma
ARGIN - Overview: Arginase-1 Immunostain, Technical Component Only
Identification and differentiation of hepatocellular carcinoma
SMACN - Overview: Actin, Smooth Muscle (SMActin) Immunostain, Technical Component Only
Identification of cells expressing the alpha-smooth muscle isoform of actin
BRAFV - Overview: BRAF V600E Immunostain, Technical Component Only
Identification of BRAF V600E-mutated protein
CD4I - Overview: CD4 Immunostain, Technical Component Only
Identification of T helper cells, histiocytes, and monocytes
CMVI - Overview: Cytomegalovirus (CMV) Immunostain, Technical Component Only
Identification of cytomegalovirus infection
Since the pandemic hit, she's spent a great deal of time vetting antibody tests and has set up a COVID-19 testing program at Mayo Clinic....
Staffing to Workload in Phlebotomy Areas: Off-Site Operational Needs - Insights
discusses staffing to workload in phlebotomy areas with a focus on off-site operational needs, including paid time off and unpaid time off....
practices from the program, Mayo Medical Laboratories collaborated with National Decision Support Company (NDSC) to combine Mayo’s clinical knowledge with NDSC’s industry-leading expertise in electronic...
Laboratory and pathology research roundup: August 30 - Insights
This week's research roundup features: Kidney biopsy chronicity grading in antineutrophil cytoplasmic antibody-associated vasculitis...
Visit Mayo Clinic Laboratories at the APA Annual Meeting - Insights
Visit Mayo Clinic Laboratories at booth #2047 to learn about our comprehensive therapeutics test offerings. Developed by board-certified experts in clinical chemistry, molecular, and toxicology testing...