Detecting the presence of acetone, methanol, isopropanol,
Headspace Gas Chromatography-Flame Ionization Detector (HSGC-FID)
Acetone
Alcohol
Ethanol
Ethyl Alcohol
ETOH (Ethanol)
Isopropanol
Methanol
Urine
For best clinical correlation either VLTS / Volatile Screen, Serum or VLTB / Volatile Screen, Blood is recommended.
Supplies: Urine Tubes, 10 mL (T068)
Container/Tube: Plastic, 10-mL urine tube
Specimen Volume: 10 mL
Collection Instructions:
1. Collect a random urine specimen.
2. No preservative.
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.
1 mL
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability. |
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Urine | Refrigerated (preferred) | 14 days | |
Frozen | 28 days | ||
Ambient | 24 hours |
Detecting the presence of acetone, methanol, isopropanol,
Urine provides a medium for easy screening for methanol, ethanol, isopropanol, and acetone.
METHANOL
Not detected (Positive results are quantitated.)
Cutoff concentration: 10 mg/dL
Toxic concentration: > or =10 mg/dL
ETHANOL
Not detected (Positive results are quantitated.)
Cutoff concentration: 10 mg/dL
ISOPROPANOL
Not detected (Positive results are quantitated.)
Cutoff concentration: 10 mg/dL
Toxic concentration: > or =10 mg/dL
ACETONE
Not detected (Positive results are quantitated.)
Cutoff concentration: 10 mg/dL
Toxic concentration: > or =10 mg/dL
Methanol
The presence of methanol indicates exposure which may result in intoxication, central nervous system (CNS) depression, and metabolic acidosis. Ingestion of methanol can be fatal if patients do not receive immediate medical treatment.
Ethanol
The presence of ethanol indicates exposure which may result in intoxication, CNS depression, and metabolic acidosis.
Isopropanol
The presence of isopropanol indicates exposure which may result in intoxication and CNS depression. Ingestion of isopropanol can be fatal if patients do not receive immediate medical treatment.
Acetone
The presence of acetone may indicate exposure to acetone; it is also a metabolite of isopropanol and may be detected during ketoacidosis.
Quantitation of acetone, methanol, isopropanol, or ethanol in urine correlates poorly with degree of intoxication.
1. Langman LJ, Bechtel LK, Meier BM, Holstege C: Chapter 41: Clinical Toxicology. In: Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Edited by N Rifai, AR Horvath, CT Wittwer. Sixth edition. Elsevier; 2018. pp. 832-87
2. Mihic SJ, Koob GF, Mayfield J, Harris RA: Ethanol. In: Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13th edition. Edited by LL Brunton, R Hilal-Dandan, BC Knollmann. McGraw-Hill Education; 2017
3. Olson KR, Anderson IB, Benowitz NL, et al: Specific Poisons and Drugs: Diagnosis and Treatment. In Poisoning and Drug Overdose, Seventh edition. McGraw-Hill Education; 2017
Specimens are analyzed and quantified by headspace gas chromatography- flame ionization detection.(Baselt RC. Disposition of Toxic Drugs and Chemicals in Man, 10th edition, Biomedical Publications; 2014. pp 2211)
Monday through Saturday
This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.
80320
G0480 (if appropriate)
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
VLTU | Volatile Scrn, U | 24350-1 |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
8826 | Volatile Scrn, U | 12983-3 |
30904 | Methanol, U | 5695-2 |
30905 | Ethanol, U | 5645-7 |
30906 | Acetone, U | 5570-7 |
30907 | Isopropanol, U | 9434-2 |
34378 | Chain of Custody | 77202-0 |