IHCFH - Overview: Fumarate Hydratase Immunostain, Technical Component Only

Identifying fumarate hydratase-deficient neoplasms Supporting the diagnosis of an atypical smooth muscle tumor over leiomyosarcoma

CAIX - Overview: Carbonic Anhydrase IX (CA-IX) Immunostain, Technical Component Only

Diagnosis of clear cell renal cell carcinoma and clear cell papillary renal cell carcinoma

CD33 - Overview: CD33 Immunostain, Technical Component Only

Classification of myeloid neoplasms and acute leukemias

HSCRP - Overview: C-Reactive Protein, High Sensitivity, Serum

Assessment of risk of developing myocardial infarction in patients presenting with acute coronary syndromes Assessment of risk of developing cardiovascular disease or ischemic events in individuals who do not manifest disease at present

FUFXS - Overview: Fragile X, Follow-up Analysis

Confirming the methylation status of the repeat expansion allele in the FMR1 gene, to aid the diagnosis of FMR1-related disorders

HISME - Overview: Histone H3 Trimethyl K27 Immunostain, Technical Component Only

Diagnosis of malignant peripheral nerve sheath tumors and diffuse midline gliomas H3 K27M-mutant

HK36M - Overview: Histone H3 K36M Mutant (H3F3 K36M) Immunostain, Technical Component Only

Diagnosis of chondroblastoma

MTAP - Overview: Methylthioadenosine Phosphorylase (MTAP) Immunostain, Tech Only

Aiding in the diagnosis of malignant mesothelioma

KRTAE - Overview: Keratin (AE1/AE3) Immunostain, Technical Component Only

Identification of cells expressing a broad spectrum of cytokeratins (low and high molecular weight keratins)

HK27M - Overview: Histone H3 K27M Mutant (H3 K27M) Immunostain, Technical Component Only

Identifying the presence of altered H3 K27M protein

LMO2 - Overview: LIM Domain Only 2 (LMO2) Immunostain, Technical Component Only

Classification of lymphomas

MELAN - Overview: Melan A (MART-1) Immunostain, Technical Component Only

Aids in the identification of melanoma

PIT1 - Overview: PIT-1 Immunostain, Technical Component Only

Classification of pituitary adenomas

PHTDP - Overview: Phosphorylated TDP43 Immunostain, Technical Component Only

Identification of pathological forms of TDP-43 in neurodegenerative diseases

PRL - Overview: Prolactin, Serum

Aiding in evaluation of pituitary tumors, amenorrhea, galactorrhea, infertility, and hypogonadism Monitoring therapy of prolactin-producing tumors

P53 - Overview: p53 Immunostain, Technical Component Only

Aiding in the identification of neoplastic cells

PTHRP - Overview: Parathyroid Hormone-Related Peptide, Plasma

Aiding in the evaluation of individuals with hypercalcemia of unknown origin Aiding in the evaluation of individuals with suspected humoral hypercalcemia of malignancy The test should not be used to exclude cancer or screen individuals...

P40 - Overview: p40 Immunostain, Technical Component Only

Diagnosis and classification of carcinomas and lymphomas

P16 - Overview: p16 (INK4a/CDKN2A) Immunostain, Technical Component Only

Aids in the identification of human papilloma virus infection

TTFK5 - Overview: Thyroid Transcription Factor 1 (TTF1) (SPT24) and Keratin 5 (KRT5) Immunostain, Technical Component Only

Thyroid transcription factor 1aids in the classification of carcinomas of unknown origin Keratin 5 aids in the identification of squamous cell carcinoma

TPIT - Overview: T-PIT Immunostain, Technical Component Only

Diagnosis of corticotroph, silent corticotroph, and null cell adenomas of the pituitary

TYROS - Overview: Tyrosinase (TYROS) Immunostain, Technical Component Only

Aiding in the identification of normal melanocytes and malignant melanoma

SABP - Overview: Streptococcal Antibodies Profile, Serum

Demonstration of acute or recent streptococcal infection using both antistreptolysin O and anti-DNase B titers

SOX11 - Overview: SOX11 Immunostain, Technical Component Only

Identification of mantle cell lymphomas

HG34W - Overview: Histone 3.3 G34W (H3F3A G34W) Immunostain, Technical Component Only

Aiding in the diagnosis of giant cell tumor of bone

1A2Q - Overview: Cytochrome P450 1A2 Genotype, Varies

Identifying individuals who are poor, intermediate, normal (extensive) or rapid metabolizers of drugs metabolized by cytochrome P450 1A2 to assist drug therapy decision making

HIAAR - Overview: 5-Hydroxyindoleacetic Acid, Random, Urine

Biochemical diagnosis and monitoring of intestinal carcinoid syndrome using random urine specimens

IGGS - Overview: IgG Subclasses, Serum

Second-order testing for evaluation of patients with clinical signs and symptoms of humoral immunodeficiency or combined immunodeficiency (cellular and humoral)

UBKQN - Overview: BK Virus DNA Detection and Quantification, Random, Urine

Detection and serial monitoring of BK virus (BKV)-associated nephropathy in kidney transplant recipients using random urine specimens Detection and serial monitoring of BKV-associated hemorrhagic cystitis in organ transplant recipients

TGMS - Overview: Thyroglobulin Mass Spectrometry, Serum

Accurate measurement of serum thyroglobulin (Tg) in patients with known or suspected antithyroglobulin autoantibodies (TgAb) or heterophile antibodies (HAb) Reflex testing of samples with previously unknown TgAb status that prove TgAb...

ALPS - Overview: Alpha Beta Double-Negative T Cells for Autoimmune Lymphoproliferative Syndrome, Blood

Diagnosing autoimmune lymphoproliferative syndrome, primarily in patients younger than 45 years

COCOU - Overview: Cortisol/Cortisone, Free, 24 Hour, Urine

Screening test for Cushing syndrome (hypercortisolism) Assisting in diagnosing acquired or inherited abnormalities of 11-beta-hydroxy steroid dehydrogenase (cortisol to cortisone ratio) Diagnosis of pseudo-hyperaldosteronism due to...

TOXGP - Overview: Toxoplasma gondii Antibody, IgG, Serum

Determining whether a patient has had previous exposure to or recent infection with Toxoplasma gondii This test is not useful for diagnosing infection in infants younger than 6 months of age. In that age group, IgG antibodies usually are...

VWFMS - Overview: von Willebrand Factor Multimer Analysis, Plasma

Resolving discrepancies when results of complementary laboratory tests (eg, F8A / Coagulation Factor VIII Activity Assay, Plasma; VWACT / von Willebrand Factor Activity, Plasma; and VWAG / von Willebrand Factor Antigen, Plasma) are...

HIAA - Overview: 5-Hydroxyindoleacetic Acid, 24 Hour, Urine

Biochemical diagnosis and monitoring of intestinal carcinoid syndrome using 24-hour urine specimens

HSVG - Overview: Herpes Simplex Virus (HSV) Type 1- and Type 2-Specific Antibodies, IgG, Serum

Determining whether a patient has been previously exposed to herpes simplex virus (HSV) types 1 and 2 Distinguishing between infection caused by HSV types 1 and 2, especially in patients with subclinical or unrecognized HSV infection...

INHB - Overview: Inhibin B, Serum

Aiding in the diagnosis of granulosa cell tumors and mucinous epithelial ovarian tumors Monitoring of patients with granulosa cell tumors and epithelial mucinous-type tumors of the ovary known to overexpress inhibin B As an adjunct to...

HSMP - Overview: Hepatosplenomegaly Panel, Plasma

As a component to the initial evaluation of a patient presenting with hepatosplenomegaly, using plasma specimens This test is not useful for the identification of carriers. This test should not be used as a monitoring tool for patients...

HSMWB - Overview: Hepatosplenomegaly Panel, Blood

As a component of the initial evaluation of a patient presenting with hepatosplenomegaly This test is not useful for the identification of carriers. This test should not be used as a monitoring for patients with confirmed diagnoses.

TBPZA - Overview: Susceptibility, Mycobacterium tuberculosis Complex, Pyrazinamide, Varies

Susceptibility testing of Mycobacterium tuberculosis complex isolates growing in pure culture against pyrazinamide This test is not useful for Mycobacterium bovis and Myocobacterium bovis bacille Calmette-Guerin (BCG) isolates as they are...

AVWPI - Overview: von Willebrand Disease Profile Technical Interpretation

Technical interpretation of the von Willebrand factor profile test Detection of deficiency or abnormality of von Willebrand factor and related deficiency of factor VIII coagulant activity Subtyping von Willebrand disease (VWD) as type 1...

CCFR - Overview: Cortisol/Cortisone, Free, Random, Urine

Investigating suspected Cushing syndrome (hypercortisolism), when a 24-hour collection is prohibitive (ie, pediatric patients). Assisting in diagnosing acquired or inherited abnormalities of 11-beta-hydroxy steroid dehydrogenase (cortisol...

2C9QT - Overview: Cytochrome P450 2C9 Genotype, Varies

Identifying individuals who may be at risk for altered metabolism of drugs that are modified by cytochrome P450 2C9

SHBG1 - Overview: Sex Hormone-Binding Globulin, Serum

Diagnosis and follow-up of women with signs or symptoms of androgen excess (eg, polycystic ovarian syndrome and idiopathic hirsutism) An adjunct in monitoring sex-steroid and antiandrogen therapy An adjunct in the diagnosis of disorders...

EOIBD - Overview: Early Onset Monogenic Inflammatory Bowel Disease (IBD) Gene Panel, Varies

Providing a comprehensive genetic evaluation for patients with a personal or family history suggestive of an inherited inflammatory bowel disorder Establishing a diagnosis of a monogenic early onset inflammatory bowel disease, allowing for...

AN2TS - Overview: Antineuronal Nuclear Antibody Type 2 (ANNA-2) Titer, Serum

Investigating middle-aged or older patients who present with unexplainable signs of midbrain/cerebellar/brain stem disorder and/or myelopathy, especially women with a previous history of breast cancer, and both sexes if there is a history...

AN2TC - Overview: Antineuronal Nuclear Antibody Type 2 (ANNA-2) Titer, Spinal Fluid

Investigating middle-aged or older patients who present with unexplainable signs of midbrain/cerebellar/brain stem disorder and/or myelopathy, especially women with a previous history of breast cancer, and both sexes if there is a history...

GLP - Overview: Glucagon, Plasma

Diagnosis and follow-up of glucagonomas and other glucagon-producing tumors Assessing diabetic patients with problematic hyper- or hypoglycemic episodes (extremely limited utility)

ROMA - Overview: ROMA Score (Ovarian Malignancy Risk Algorithm), Serum

Risk assessment for finding an ovarian malignancy during surgery in women who present with an adnexal mass The test is not intended as a screening or stand-alone diagnostic assay for ovarian cancer.

PKU - Overview: Phenylalanine and Tyrosine, Plasma

Monitoring effectiveness of dietary therapy in patients with hyperphenylalaninemia