BRACH - Overview: Brachyury Immunostain, Technical Component Only

Aiding in the identification of chordomas

BRAFV - Overview: BRAF V600E Immunostain, Technical Component Only

Identification of BRAF V600E-mutated protein

BCOR - Overview: BCOR Immunostain, Technical Component Only

Aiding in the distinction of a subset of primitive round cell sarcomas with BCOR rearrangements from other Ewing/Ewing-like sarcomas

BCL2 - Overview: BCL-2 Immunostain, Technical Component Only

Classification of lymphomas

BIOTS - Overview: Biotinidase, Serum

Preferred test for the diagnosis of biotinidase deficiency Follow-up testing for certain organic acidurias

C5DCU - Overview: C5-DC Acylcarnitine, Quantitative, Random, Urine

Evaluation of patients with an abnormal newborn screen showing elevations of glutarylcarnitine Diagnosis of glutaric aciduria type 1 deficiency

C4U - Overview: C4 Acylcarnitine, Quantitative, Random, Urine

Evaluation of patients with abnormal newborn screens showing elevations of iso-/butyrylcarnitine to aid in the differential diagnosis of short-chain acyl-CoA dehydrogenase and isobutyryl-CoA dehydrogenase deficiencies

CALRC - Overview: Calreticulin ex9mut Immunostain, Technical Component Only

Identifying the presence of CALR exon 9 frameshift alterations in myeloproliferative neoplasms

CD71 - Overview: CD71 Immunostain, Technical Component Only

Assessment of erythroid lineage

CD3I - Overview: CD3 Immunostain, Technical Component Only

Demonstrating T-cell lineage

CD4I - Overview: CD4 Immunostain, Technical Component Only

Identification of T helper cells, histiocytes, and monocytes

MERKC - Overview: Merkel CC (MCPyV) Immunostain, Technical Component Only

Identification of Merkel cell polyomavirus infected cells

OLIG2 - Overview: OLIG2 Immunostain, Technical Component Only

Distinguishing gliomas from neurocytomas and ependymomas

MESOP - Overview: Mesothelioma Panel (WT1/KRT5/TTF1/pCEA) Immunostain, Technical Component Only

Differentiation of mesothelioma and non-small cell lung cancer

C5B9 - Overview: SC5b-9 Level Terminal Complement Complex, Plasma

Detecting increased complement activation

SDHB - Overview: SDHB Immunostain, Technical Component Only

Aids in the identification of succinate dehydrogenase B-deficient tumors

HG - Overview: Mercury, Blood

Detecting mercury toxicity

NSEI - Overview: Neuron-Specific Enolase Immunostain, Technical Component Only

Characterization of neuroendocrine differentiation in tumors

NAPSN - Overview: Napsin A Immunostain, Technical Component Only

Identification of primary lung adenocarcinoma

CDKPB - Overview: CD68 (KP1) Immunostain, Bone Marrow, Technical Component Only

Aiding in the identification of histocytic and myeloid lineage cells

CRPRO - Overview: C-Reactive Protein (CRP) Immunostain, Technical Component Only

Classification of hepatic adenomas

CLAUD - Overview: Claudin-1 Immunostain, Technical Component Only

Identification of a number of different soft tissue and epithelial neoplasms

PIK3B - Overview: Cell-Free DNA PIK3CA Test, Blood

Identification of hormone receptor positive and human epidermal growth factor receptor 2 negative (HR+/HER2-) advanced breast cancer tumors that may be eligible for treatment with targeted kinase inhibitor therapy (eg, alpelisib).

CRSY - Overview: Chromium, Synovial Fluid

Monitoring metallic prosthetic implant wear and local tissue destruction in failed hip arthroplasty constructs This test is not useful for assessment of potential chromium toxicity.

EBNA2 - Overview: Epstein Barr Nuclear Antigen 2 (EBNA2) Immunostain, Technical Component Only

Identification of Epstein Barr virus infection in normal, inflammatory, and neoplastic tissues

EDN - Overview: Eosinophil Derived Neurotoxin, Serum

Evaluating patients suspected to have a condition associated with eosinophilia or hypereosinophilia Evaluating patients with elevated peripheral blood eosinophil counts Managing patients with elevated eosinophil-derived neurotoxin in the...

MELAN - Overview: Melan A (MART-1) Immunostain, Technical Component Only

Aids in the identification of melanoma

HBZ - Overview: Human T-cell Lymphotropic Virus Type 1 (HTLV-1) bZIP Factor (HBZ), In Situ Hybridization, Technical Component Only

Diagnosing adult T-cell leukemia/lymphoma

MYPO - Overview: Myeloperoxidase (MPO) Immunostain, Technical Component Only

A marker of myeloid lineage

TICU - Overview: Titanium/Creatinine Ratio, Urine

Measurement of titanium concentration as part of a profile to assess exposure and elimination of titanium

DNJB9 - Overview: DNAJB9 Immunostain, Technical Component Only

Diagnosis of fibrillary glomerulonephritis

TRK - Overview: Tropomyosin Receptor Kinase (TRK) Immunostain, Technical Component Only

Helpful in the screening for neurotrophic tyrosine receptor kinase (NTRK) rearranged tumors

FS - Overview: Fungal Smear, Varies

Detection of fungi in clinical specimens

ENC2 - Overview: Encephalopathy, Autoimmune/Paraneoplastic Evaluation, Spinal Fluid

Evaluating new onset encephalopathy (noninfectious or metabolic) comprising confusional states, psychosis, delirium, memory loss, hallucinations, movement disorders, sensory or motor complaints, seizures, dyssomnias, ataxias, nausea,...

BRBPS - Overview: Broad Range Bacterial PCR and Sequencing, Varies

Detecting and identifying bacteria (including mycobacteria) from normally sterile sources, including synovial fluid; body fluids such as pleural, peritoneal, and pericardial fluids, cerebrospinal fluid; and both fresh and formalin-fixed...

NAGR - Overview: Hexosaminidase A and Total, Leukocytes/Molecular Reflex, Whole Blood

Carrier detection and diagnosis of Tay-Sachs disease Carrier detection and diagnosis of Sandhoff disease

CRCGP - Overview: Hereditary Gastrointestinal Cancer Panel, Varies

Evaluating patients with a personal or family history suggestive of a hereditary gastrointestinal cancer or hereditary polyposis syndrome Establishing a diagnosis of a hereditary gastrointestinal cancer syndrome or hereditary polyposis...

LYNCP - Overview: Lynch Syndrome Panel, Varies

Establishing a diagnosis of Lynch syndrome or constitutional mismatch repair deficiency allowing for targeted cancer surveillance based on associated risks Identifying MLH1, MSH2, MSH6, PMS2, or EPCAM variants to allow for predictive...

MCSRC - Overview: MayoComplete Comprehensive Sarcoma Panel, Next-Generation Sequencing, Tumor

Primarily for identifying mutations that help in the diagnosis of specific soft tissue and bone tumors (sarcoma) Secondarily for identifying mutations that have therapeutic or prognostic significance Assessing microsatellite instability...

GNANT - Overview: Antithrombin Deficiency, SERPINC1 Gene, Next-Generation Sequencing, Varies

Evaluating antithrombin AT deficiency in patients with a personal or family history suggestive of this hereditary thrombophilia Confirming an AT deficiency diagnosis with the identification of a known or suspected disease-causing...

CCMGG - Overview: Comprehensive Cardiomyopathy Gene Panel, Varies

Providing a genetic evaluation for patients with a personal or family history suggestive of a hereditary form of cardiomyopathy Establishing a diagnosis of a hereditary form of cardiomyopathy

CRTS1 - Overview: Creatinine with Estimated Glomerular Filtration Rate (eGFR), Serum

Diagnosing and monitoring treatment of acute and chronic kidney diseases Adjusting dosage of renally excreted medications Monitoring kidney transplant recipients Estimating glomerular filtration rate for people with chronic kidney...

G6PD1 - Overview: Glucose 6-Phosphate Dehydrogenase Enzyme Activity, Blood

Evaluation of individuals with episodic or chronic Coombs-negative nonspherocytic hemolytic anemia Rapid testing to assess glucose 6-phosphate dehydrogenase (G6PD) enzyme capacity prior to rasburicase or other therapies that may cause...

WARSQ - Overview: Warfarin Response Genotype, Varies

Identifying patients who may require warfarin dosing adjustments(3,4) including: -Patients being started on a first prescription for warfarin -Patients who have previously been prescribed warfarin and have required multiple dosing...

VHPV - Overview: Human Papillomavirus (HPV) Vaginal Detection with Genotyping for High-Risk Types by PCR

Detection of high-risk (HR) genotypes associated with the development of cervical cancer Aids in triaging women with abnormal Pap smear results Individual genotyping of human papillomavirus (HPV)-16 and/or HPV-18 if present Results of...

DMS2 - Overview: Dementia, Autoimmune/Paraneoplastic Evaluation, Serum

Investigating new onset dementia and cognitive impairment plus 1 or more of the following using serum specimens: -Rapid onset and progression -Fluctuating course -Psychiatric accompaniments (psychosis, hallucinations) -Movement disorder...

DMC2 - Overview: Dementia, Autoimmune/Paraneoplastic Evaluation, Spinal Fluid

Investigating new onset dementia and cognitive impairment plus 1 or more of the following accompaniments using cerebrospinal fluid specimens: -Rapid onset and progression -Fluctuating course -Psychiatric accompaniments (psychosis,...

MAS1 - Overview: Myelopathy, Autoimmune/Paraneoplastic Evaluation, Serum

Evaluating patients with suspected autoimmune myelopathy, myelitis, and paraneoplastic myelopathy using serum specimens

BLWX - Overview: Walnut-Food Components, IgE, Serum

Evaluation of patients with suspected walnut-food allergy to one of 2 walnut-food components

PD2T - Overview: Pompe Disease Second-Tier Newborn Screening, Blood Spot

Second-tier testing of newborns with an abnormal primary screening result for Pompe disease (decreased acid alpha-glucosidase enzyme activity) Follow-up testing for evaluation of an abnormal newborn screening result for Pompe disease