Identification of individuals who may be at risk for aminoglycoside-induced hearing loss (AIHL) Establishing a diagnosis of late-onset sensorineural hearing loss associated with aminoglycoside exposure Identifying mitochondrial variants...
NHEP - Overview: Hereditary Erythrocytosis Gene Panel, Next-Generation Sequencing, Varies
Evaluating an individual with JAK2-V617F negative erythrocytosis associated with lifelong sustained increased red blood cell (RBC) mass, elevated RBC count, hemoglobin, or hematocrit Providing an extensive genetic evaluation for patients...
PFAPC - Overview: Fatty Acid Profile, Comprehensive (C8-C26), Plasma
Monitoring patients undergoing diet therapy for mitochondrial or peroxisomal disorders (possibly inducing essential fatty acid deficiency in response to restricted fat intake) using plasma specimens Monitoring treatment of essential fatty...
FAPCP - Overview: Fatty Acid Profile, Comprehensive (C8-C26), Serum
Monitoring patients undergoing diet therapy for mitochondrial or peroxisomal disorders (possibly inducing essential fatty acid deficiency in response to restricted fat intake) using serum specimens Monitoring treatment of essential fatty...
Diagnosing growth disorders Diagnosing adult growth hormone deficiency Monitoring of recombinant human growth hormone treatment Insulin-like growth factor binding protein 3 can be used as a possible adjunct to insulin-like growth...
PSA - Overview: Prostate-Specific Antigen (PSA) Diagnostic, Serum
As an aid in the detection of prostate cancer when used in conjunction with a digital rectal exam in men 50 years and older To aid in the prognosis and management of individuals diagnosed with prostate cancer
PRL - Overview: Prolactin, Serum
Aiding in evaluation of pituitary tumors, amenorrhea, galactorrhea, infertility, and hypogonadism Monitoring therapy of prolactin-producing tumors
TDP - Overview: Thiamine (Vitamin B1), Whole Blood
Assessment of thiamine deficiency Measuring thiamine levels in patients with behavioral changes, eye signs, gait disturbances, delirium, and encephalopathy; or in patients with questionable nutritional status, especially those who appear...
WNMS - Overview: West Nile Virus Antibody, IgM, Serum
Detection of IgM antibodies in West Nile virus infections
ROM - Overview: Measles (Rubeola) Antibodies, IgM, Serum
Determining acute-phase infection with rubeola (measles) virus using IgM antibody testing Aiding in the identification of nonimmune individuals through IgM antibody testing
PBLI - Overview: Plasma Cell Assessment, Blood
Detecting peripheral blood involvement by plasma cell proliferative disorders Establishing the diagnosis of and determining prognosis for plasma cell proliferative disorders
RBPG - Overview: Rubella Antibodies, IgG, Serum
Determining immune status to the rubella virus
HMHA - Overview: Heavy Metals, Hair
Detection of nonacute arsenic, mercury, and lead exposure using hair specimens
GALP - Overview: Galactose, Quantitative, Plasma
Screening for galactosemia
GALK - Overview: Galactokinase, Blood
Diagnosis of galactokinase deficiency Evaluation of children with unexplained bilateral congenital or juvenile onset cataracts
Identifying class I and II human leukocyte antigens (HLA) for potential disease associations or markers for drug hypersensitivity
FIL - Overview: Filaria, Blood
Detecting microfilariae in peripheral blood
MINT - Overview: Molecular Interpretation
Interpretation of the hereditary erythrocytosis profile
KI67B - Overview: Ki-67(MIB-1), Breast, Quantitative Immunohistochemistry, Automated
Determining proliferation of tumor cells in paraffin-embedded tissue blocks from patients diagnosed with breast carcinoma
ALKP - Overview: Alkaline Phosphatase, Total and Isoenzymes, Serum
Aid in the diagnosis and treatment of liver, bone, intestinal, and parathyroid diseases Determining the tissue source of increased alkaline phosphatase (ALP) activity in serum Differentiating between liver and bone sources of elevated ALP
BILI3 - Overview: Bilirubin, Serum
Assessing liver function Evaluating a wide range of diseases affecting the production, uptake, storage, metabolism, or excretion of bilirubin Monitoring the efficacy of neonatal phototherapy
NBILI - Overview: Neonatal Bilirubin, Serum
Assessing liver function Evaluating a wide range of diseases affecting the production, uptake, storage, metabolism, or excretion of bilirubin Monitoring the efficacy of neonatal phototherapy
SSCTU - Overview: S-Sulfocysteine Panel, Urine
Diagnosis of molybdenum cofactor deficiency, isolated sulfite oxidase deficiency, and hereditary xanthinuria Monitoring patients with molybdenum cofactor deficiency or isolated sulfite oxidase deficiency who are on treatment
NMRLP - Overview: Nuclear Magnetic Resonance Lipoprotein Profile, Serum
Assessment and management of a patient's risk for atherosclerotic cardiovascular disease Identifying residual risk that may be present in some patients on cholesterol targeting treatment
TXM - Overview: Toxoplasma gondii Antibody, IgM, Serum
Detecting recent infection with Toxoplasma gondii
TPO - Overview: Thyroperoxidase Antibodies, Serum
Aiding in the diagnosis of thyroid autoimmune disorders Differentiating thyroid autoimmune disorders from nonautoimmune goiter or hypothyroidism As a diagnostic tool in deciding whether to treat a patient who has subclinical...
CARTF - Overview: Carbamazepine Profile, Serum
Monitoring patients exhibiting symptoms of carbamazepine toxicity whose total serum carbamazepine concentration is within the therapeutic range, but who may be producing significant levels of the active metabolite epoxide Free...
OPTU - Overview: Orthostatic Protein, Timed Collection, Urine
Diagnosis of orthostatic proteinuria As a second-order test for additional characterization of proteinuria of less than 3 grams/24 hours, particularly in children or adolescents
PLABN - Overview: Platelet Antibody Screen, Serum
Detecting alloantibodies to epitopes on platelet glycoproteins IIb/IIIa, Ib/Ix, Ia/IIa, IV and class I human leukocyte antigens to evaluate cases of immune mediated refractoriness to platelet transfusions, posttransfusion purpura, or...
GLP - Overview: Glucagon, Plasma
Diagnosis and follow-up of glucagonomas and other glucagon-producing tumors Assessing diabetic patients with problematic hyper- or hypoglycemic episodes (extremely limited utility)
FRBP - Overview: Retinol Binding Protein
Retinol Binding Protein
PBCPN - Overview: Primary Biliary Cholangitis Antibody Panel, Serum
Evaluation of at-risk or previously diagnosed primary biliary cholangitis patients with new features of other liver diseases or systemic autoimmune diseases
HIVDX - Overview: HIV-1 and HIV-2 Antigen and Antibody Diagnostic Evaluation, Plasma
Detecting HIV-1 and HIV-2 infection in symptomatic patients older than 2 years Follow-up testing of symptomatic individuals with reactive rapid HIV test results This test should not be used as a screening or confirmatory test for blood...
Detection of high-risk (HR) genotypes associated with the development of cervical cancer Aids in triaging women with abnormal Pap smear results Individual genotyping of human papillomavirus (HPV)-16 and/or HPV-18 if present Results of...
NONCP - Overview: Neuro-Oncology Expanded Gene Panel with Rearrangement, Tumor
Identifying mutations and rearrangements that may support a diagnosis or help determine prognosis for patients with CNS tumors Identifying specific mutations and rearrangements within genes known to be associated with response or...
BRTP - Overview: Rapid Hereditary Breast Cancer Treatment Decision Panel, Varies
Establishing a diagnosis of a hereditary breast cancer syndrome allowing for surgical and management decision making Determining therapeutic eligibility with poly (adenosine diphosphate-ribose) polymerase inhibitors based on certain gene...
DRVI1 - Overview: Dilute Russell's Viper Venom Time (DRVVT), with Reflex, Plasma
Detecting and confirming or helping to exclude the presence of lupus anticoagulants (LA) Identifying LA that do not prolong the activated partial thromboplastin time (APTT) Evaluating unexplained prolongation of the APTT or prothrombin...
G6PD1 - Overview: Glucose 6-Phosphate Dehydrogenase Enzyme Activity, Blood
Evaluation of individuals with episodic or chronic Coombs-negative nonspherocytic hemolytic anemia Rapid testing to assess glucose 6-phosphate dehydrogenase (G6PD) enzyme capacity prior to rasburicase or other therapies that may cause...
STICK - Overview: Tick-Borne Antibodies, Modified 2-Tier, ELISA, Serum
Evaluation of the most common tick-borne diseases found in the United States, including Lyme disease, human monocytic and granulocytic ehrlichiosis, and babesiosis using the modified 2-tier testing algorithm approach Evaluation of patients...
Evaluation of known or suspected hematologic neoplasms, specifically of myeloid origin (eg, acute myeloid leukemia, myelodysplastic syndrome, myeloproliferative neoplasm, myelodysplastic/myeloproliferative neoplasm, unexplained cytopenias)...
IGFMS - Overview: Insulin-Like Growth Factor-1, Mass Spectrometry, Serum
Evaluation of growth disorders Evaluation of growth hormone deficiency or excess in children and adults Monitoring of recombinant human growth hormone treatment Follow-up of individuals with acromegaly and gigantism
OPE - Overview: Ova and Parasite, Travel History or Immunocompromised, Feces
Detecting and identifying parasitic protozoa and eggs and larvae of parasitic helminths in stool specimens
SPSA - Overview: Prostate-Specific Antigen (PSA) Screen, Serum
As a screening aid in the detection of prostate cancer when used in conjunction with a digital rectal exam in men 50 years or older Screening to aid in the prognosis and management of individuals diagnosed with prostate cancer
PTTP - Overview: Prothrombin Time, Plasma
Screening assay to detect deficiencies of one or more coagulation factors (factors I, II, V, VII, X) Screening assay to detect coagulation inhibition Monitoring intensity of oral anticoagulant therapy when combined with INR reporting
PTHFN - Overview: Parathyroid Hormone, Fine-Needle Aspiration Biopsy (FNAB)-Needle Wash
Discriminating thyroid tissue from enlarged parathyroid glands Facilitating parathyroid localization prior to surgery An adjunct to cytology examination of fine-needle aspiration specimens to confirm or exclude presence of parathyroid...
DHVD - Overview: 1,25-Dihydroxyvitamin D, Serum
As a second-order test in the assessment of vitamin D status, especially in patients with renal disease Investigation of some patients with clinical evidence of vitamin D deficiency (eg, vitamin D-dependent rickets due to hereditary...
Detection of RUNX1-RUNX1T1 gene fusion in acute myeloid leukemia patients at the time of diagnosis Minimal residual disease monitoring during the clinical and therapeutic course of these patients
QFP - Overview: Q Fever IgM and IgG, Titer, Serum
Diagnosis of Coxiella burnetii, the causative agent of Q fever
FRDIG - Overview: Digoxin, Free, Serum
Evaluating recrudescent (breakthrough) digoxin toxicity in renal-failure patients Assessing the need for more antidigoxin Fab to be administered Deciding when to reintroduce digoxin therapy Monitoring patients with possible...
SSB - Overview: SS-B/La Antibodies, IgG, Serum
Evaluating patients with clinical features or at-risk for connective tissue disease, especially Sjögren syndrome.
Information: Interpreting Laboratory Tests to Determine New vs. Residual Use of Marijuana - Insights
In this month's "Hot Topic," Paul Jannetto, Ph.D., identifies how to determine new vs. residual use of marijuana in a patient, and teaches how to calculate the carboxy-tetrahydrocannabinol (carboxy-THC)...
Laboratory and Pathology Research Roundup: March 12 - Insights
known. We performed laser microdissection (LCM) of glomeruli followed by mass spectrometry (MS) in 12 cases each of DDD, C3GN, and pretransplant kidney control biopsies....
COVID-19: At-home sample collection vs. at-home testing - Insights
The concept of at-home testing for COVID-19 sounds straightforward. But there's nuance to it that's important to understand. Right now, an at-home test for COVID-19 is not available, although there may be one coming soon. But in some areas,...
Clinic Laboratory and Pathology Research Roundup: Nov. 12 - Insights
This week’s Research Roundup highlights a mechanism for preventing asymmetric histone segregation onto replicating DNA strands.
Transfusion Toons: A1 vs. A2 - Insights
Justin Kreuter, M.D., Clinical Pathologist and Medical Director of the Mayo Clinic Blood Donor Center in Rochester, Minnesota, and Theresa Malin, an Education Specialist in Transfusion Medicine at Mayo Clinic, have launched “Transfusion...