Test Catalog

Test Id : FNTSM

Neurotransmitter Profile 3

Profile Information
A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test Id Reporting Name Available Separately Always Performed
F5MET 5-Methyltetrahydrofolate Yes, (order F5M) Yes
FNTM Neurotransmitter Metabolites/Amines Yes, (order FNEU) Yes
FFTHB Tetrahydrobiopterin/Neopterin Yes, (order FFTEN) Yes

Method Name
A short description of the method used to perform the test

High Performance Liquid Chromatography-Electrochemistry & Fluorescences

NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test

Neurotransmitter Profile 3

Lists additional common names for a test, as an aid in searching


Neurotransmitter Metabolites

Neurotransmitter Metabolites/Amines


Specimen Type
Describes the specimen type validated for testing


Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Medical Neurogenetics collection kit (MCL Supply T657) required.

Each collection kit contains 5 microcentrifuge tubes.



1) CSF should be collected from the first drop into the tubes in the numbered order. Fill each tube to the marked line with the required volumes.


Tube 1: 0.5 mL

Tube 2: 1.0 mL

Tube 3: 1.0 mL (contains antioxidants necessary to protect the same integrity)

Tube 4: 1.0 mL

Tube 5: 1.0 mL


-If samples not blood contaminated, the tubes should be placed on dry ice at bedside.

-If samples are blood contaminated, the tubes should immediately be centrifuged (prior to freezing) and the clear CSF transferred to new similarly labeled tubes, then frozen.

-Store samples at -80 until they can be shipped.


2) Complete Medical Neurogenetics, LLC request form, marking the following three tests: Neurotransmitter Metabolites, Tetrahydrobiopterin and 5-Methyltetrahydrofolate. Also include sample date and date of birth.


3) Label tubes with patient name and ID number, leaving the tube number viewable.


4) Place samples inside the specimen transport bag and the Medical Neurogenetics, LLC request form inside the pouch of the transport bag.


5) Ship samples frozen on dry ice.

Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected

Specimens other than CSF in special collection kit (MCL supply T657)
Anticoagulants other than NA
Hemolysis NA
Lipemia NA
Icteric NA

Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen Type Temperature Time Special Container

Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.


Age           5MTHF             

(years)      (nmol/L)           


0-0.2         40-240

0.2-0.5      40-240

0.5-2.0      40-187

2.0-5.0      40-150   

5.0-10       40-128  

10-15        40-120   

Adults       40-120


Neurotransmitter Metabolites/Amines

Age           5HIAA              HVA             3-O-MD

(years)      (nmol/L)           (nmol/L)        (nmol/L)


0-0.2        208-1159           337-1299         <300

0.2-0.5      179-711            450-1132         <300

0.5-2.0      129-520            294-1115         <300

2.0-5.0         74-345            233-928          <150

5.0-10          66-338            218-852           <100

10-15           67-189            167-563           <100

Adults         67-140            145-324            <100


Tetrahydrobiopterin/Neopterin Profile

Age            BH4                Neop

(years)      (nmol/L)           (nmol/L)        

0-0.2          40-105                7-65          

0.2-0.5       23-98                            7-65

0.5-2.0       18-58                  7-65

2.0-5.0       18-50                  7-65  

5.0-10          9-40                   7-40      

10-15           9-32                   8-33

Adults        10-30                  8-28



Note: If test results are inconsistent with the clinical presentation, please call our laboratory to discuss the case and/or submit a second sample for confirmatory testing.


DISCLAIMER required by the FDA for high complexity clinical laboratories: HPLC testing was developed and its performance

characteristics determined by Medical Neurogenetics. These HPLC tests have not been cleared or approved by the U.S. FDA.

PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information


Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Monday through Friday

Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.

14 to 18 days

Performing Laboratory Location
Indicates the location of the laboratory that performs the test

Medical Neurogenetics, LLC

Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.

  • Authorized users can sign in to Test Prices for detailed fee information.
  • Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
  • Prospective clients should contact their Regional Manager. For assistance, contact Customer Service.

CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.

CPT codes are provided by the performing laboratory.

82542 – 5-Methyltetrahydrofolate

 82542 – Tetrahydrobiopterin/Neopterin

 82542, 83497, 83150 – Neurotransmitter Metabolites/Amines


LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.

Test Id Test Order Name Order LOINC Value
FNTSM Neurotransmitter Profile 3 Not Provided
Result Id Test Result Name Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
Z1726 5-Methyltetrahydrofolate 47547-5
Z1730 Neopterin 34146-1
Z1731 Tetrahydrobiopterin 59247-7
Z1732 Interpretation Not Provided
Z1727 5-Hydroxyindoleacetic acid 47544-2
Z1728 Homovanillic acid 40846-8
Z1729 3-O-methyldopa 34596-7

Test Setup Resources

Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.

Excel | Pdf

Sample Reports
Normal and Abnormal sample reports are provided as references for report appearance.

Normal Reports | Abnormal Reports

SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.

SI Normal Reports | SI Abnormal Reports