A short description of the method used to perform the test
Liquid chromatography tandem mass spectrometry (LC/MS/MS); equilibrium dialysis; immunoradiometric assay (IRMA)
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Lists a shorter or abbreviated version of the Published Name for a test
Free Estradiol with SHBG
Lists additional common names for a test, as an aid in searching
Estradiol, Free, Serum
Free Estradiol, Serum
Describes the specimen type validated for testing
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Draw blood in a plain red-top tube (serum gel tube is acceptable). Spin down, pour off into plastic vial within 45 minutes of collection, and send 3 mL serum frozen.
Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory
1.0 mL Note: This volume does not allow for repeat testing.
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
| Hemolysis || NA |
| Lipemia || NA |
| Icterus || NA |
| Other || Plasma |
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Estradiol, Serum MS
Levels are markedly elevated at birth and fall rapidly during the first week to prepubertal values of <15.
Males <6 m
Levels increase to 10 - 32 between 30 and 60 days, then decline to prepubertal levels of <15 by six months.
Females <1 y
Levels increase to 5.0 - 50 between 30 and 60 days, then decline to prepubertal levels of <15 during the first year.
Adult Males 8.0 - 35
Follicular 30 - 100
Luteal 70 - 300
Free Estradiol, Percent
Adult Males 1.7 - 5.4
Adult Females 1.6 - 3.6
Free Estradiol, Serum
Adult Males 0.2 - 1.5
Adult Females 0.6 - 7.1
Sex Hormone Binding Globulin
Infants (1 - 23m) 60.0 - 252.0
Prepubertal 72.0 - 220.0
Males 16.0 - 100.0
Females 36.0 - 125.0
20 - 49 y 16.5 - 55.9
>49y 19.3 - 76.4
20 – 49y 24.6 - 122.0
>49y 17.3 - 125.0
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Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
CPT codes are provided by the performing laboratory.
82681 – Free Estradiol
84270 - Sex Hormone binding globulin
82670 - Estradiol
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
||Test Order Name
Order LOINC Value
||Free Estradiol with SHBG
||Test Result Name
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
||Free Estradiol, Percent
||Free Estradiol, Serum
||Sex Hormone Binding Globulin (SHBG)
Test Setup Resources
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.
SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.
SI Normal Reports |
SI Abnormal Reports