Enzyme-Linked Immunosorbent Assay (ELISA)
Gastric Parietal Cell
Serum
Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Specimen Volume: 0.5 mL
0.45 mL
Gross hemolysis | Reject |
Gross lipemia | Reject |
Gross icterus | OK |
Heat-treated specimen | Reject |
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Serum | Refrigerated (preferred) | 21 days | |
Frozen | 21 days |
Negative: < or =20.0 Units
Equivocal: 20.1-24.9 Units
Positive: > or =25.0 Units
Reference values apply to all ages.
A negative result does not rule out the presence of parietal cell antibodies; the concentration of antibody may be below the detection limit of the assay.
A positive result only indicates the presence of antibody to H(+)/K(+) ATPase and does not necessarily indicate the presence of autoimmune disease or other diseases.
The assay performance has not been established for pediatric patients.
Results of this assay should be used in conjunction with clinical findings and other serological tests.
The assay performance characteristics have not been established for matrices other than serum.
1. Toh BH, Van Driel IR, Gleeson PA: Pernicious anemia. N Eng J Med. 1997;337(20):1441-1448
2. Bizzaro N, Antico A: Diagnosis and classification of pernicious anemia. Autoimmun Rev. 2014;13(4-5):565-568
3. Toh BH: Pathophysiology and laboratory diagnosis of pernicious anemia. Immunol Res. 2017;65(1):326-330
4. Lenti MV, Rugge M, Lahner E, et al: Autoimmune gastritis. Nat Rev Dis Primers. 2020 Jul 9;6(1):56
6. Oo TH: Diagnostic difficulties in pernicious anemia. Discov Med. 2019;28(155):247-253
Tuesday, Friday
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.
83516
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
PCAB | Parietal Cell Ab, IgG, S | 40960-7 |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
PCAB | Parietal Cell Ab, IgG, S | 40960-7 |