Establishing the diagnosis of an allergy to lime
Defining the allergen responsible for eliciting signs and symptoms
Identifying allergens:
- Responsible for allergic disease and/or anaphylactic episode
- To confirm sensitization prior to beginning immunotherapy
- To investigate the specificity of allergic reactions to insect venom allergens, drugs, or chemical allergens
Testing for IgE antibodies is not useful in patients previously treated with immunotherapy to determine if residual clinical sensitivity exists, or in patients in whom the medical management does not depend upon identification of allergen specificity.
Fluorescence Enzyme Immunoassay (FEIA)
Citrus aurantifolia
Green Lemon
Sour Lemon
Serum
For a listing of allergens available for testing, see Allergens - Immunoglobulin E (IgE) Antibodies in Special Instructions.
Container/Tube:
Preferred: Red top
If not ordering electronically, complete, print, and send an Allergen Test Request (T236) with the specimen.
More than 1 allergen: (0.05 mL x number of allergens) + 0.25 mL dead space
Gross hemolysis | OK |
Gross lipemia | OK |
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Serum | Refrigerated (preferred) | 14 days | |
Frozen | 90 days |
Establishing the diagnosis of an allergy to lime
Defining the allergen responsible for eliciting signs and symptoms
Identifying allergens:
- Responsible for allergic disease and/or anaphylactic episode
- To confirm sensitization prior to beginning immunotherapy
- To investigate the specificity of allergic reactions to insect venom allergens, drugs, or chemical allergens
Testing for IgE antibodies is not useful in patients previously treated with immunotherapy to determine if residual clinical sensitivity exists, or in patients in whom the medical management does not depend upon identification of allergen specificity.
Clinical manifestations of immediate hypersensitivity (allergic)
In vitro serum testing for IgE antibodies provides an indication of the
The allergens chosen for testing often depend upon the age of the
Class | IgE kU/L | Interpretation |
0 | <0.35 | Negative |
1 | 0.35-0.69 | Equivocal |
2 | 0.70-3.49 | Positive |
3 | 3.50-17.4 | Positive |
4 | 17.5-49.9 | Strongly positive |
5 | 50.0-99.9 | Strongly positive |
6 | > or =100 | Strongly positive |
Reference values apply to all ages.
Detection of IgE antibodies in serum (Class 1 or greater) indicates
The level of IgE antibodies in serum varies directly with the
Some individuals with clinically insignificant sensitivity to allergens may have measurable levels of IgE antibodies in serum, and results must be interpreted in the clinical context.
False-positive results for IgE antibodies may occur in patients with markedly elevated serum IgE (>2500 kU/L) due to nonspecific binding to allergen solid phases.
Homburger HA, Hamilton RG: Allergic diseases. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd ed. Elsevier; 2017:1057-1070
Monday through Friday
This test was developed using an analyte specific reagent. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.
86003
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
LIME | Lime, IgE | 7464-1 |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
LIME | Lime, IgE | 7464-1 |