Useful For
Suggests clinical disorders or settings where the test may be helpful
Determination of iodine overload using serum specimens
Monitoring iodine levels in individuals taking iodine-containing drugs
Special Instructions
Library of PDFs including pertinent information and forms related to the test
Method Name
A short description of the method used to perform the test
Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Yes
Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test
Iodine, S
Specimen Type
Describes the specimen type validated for testing
Serum
Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Patient Preparation:
1. Disinfectants (such as Betadine) that contain iodine should not be used during venipuncture.
2. High concentrations of gadolinium and iodine are known to interfere with most metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Supplies: Metal Free Specimen Vial (T173)
Collection Container/Tube: Plain, royal blue-top Vacutainer plastic trace element blood collection tube
Submission Container/Tube: 7-mL Mayo metal-free, screw-capped, polypropylene vial
Specimen Volume: 1 mL
Collection Instructions:
1. Allow specimen to clot for 30 minutes; then centrifuge the specimen to separate serum from the cellular fraction.
2. Remove the stopper. Carefully pour specimen into Mayo metal-free, polypropylene vial, avoiding transfer of the cellular components of blood. Do not insert a pipet into the serum to accomplish transfer, and do not ream the specimen with a wooden stick to assist with serum transfer.
3. See Trace Metals Analysis Specimen Collection and Transport for complete instructions.
Special Instructions
Library of PDFs including pertinent information and forms related to the test
Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
Gross hemolysis | OK |
Gross lipemia | OK |
Gross icterus | OK |
Specimen Type |
Temperature |
Time |
Special Container |
Serum |
Refrigerated (preferred) |
21 days |
|
|
Ambient |
21 days |
|
|
Frozen |
21 days |
|
Useful For
Suggests clinical disorders or settings where the test may be helpful
Determination of iodine overload using serum specimens
Monitoring iodine levels in individuals taking iodine-containing drugs
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Interpretation
Provides information to assist in interpretation of the test results
Values between 80 ng/mL and 250 ng/mL have been reported to indicate hyperthyroidism.
Values above 250 ng/mL may indicate iodine overload.
Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
There are no known analytical interferences with this procedure.
Administration of iodine-containing contrast media will yield elevated results.
Clinical Reference
Recommendations for in-depth reading of a clinical nature
1. Allain P, Berre S, Krari N, et al: Use of plasma iodine assay for diagnosing thyroid disorders. J Clin Pathol. 1993 May;46(5):453-455
2. Rifai N, Horwath AR, Wittwer CT, eds: Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. Elsevier; 2018
3. Leung AM, Braverman LE: Consequences of excess iodine. Nat Rev Endocrinol. 2014 Mar;10(3):136-142. doi: 10.1038/nrendo.2013.251
4. U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry: Toxicological Profile for Iodine. HHS; 2004. Accessed November 25, 2020. Available at www.atsdr.cdc.gov/ToxProfiles/tp158.pdf
Special Instructions
Library of PDFs including pertinent information and forms related to the test
Method Description
Describes how the test is performed and provides a method-specific reference
The metal of interest is analyzed by inductively coupled plasma mass spectrometry.(Unpublished Mayo method)
PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information
No
Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
1 to 4 days
Specimen Retention Time
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
14 days
Rochester
Fees
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
- Authorized users can sign in to Test Prices for detailed fee information.
- Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
- Prospective clients should contact their account representative. For assistance, contact Customer Service.
Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.
Test Id |
Test Order Name |
Order LOINC Value
|
IOD |
Iodine, S |
2494-3 |
Result Id |
Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
81574 |
Iodine, S |
2494-3 |
Test Setup Resources
Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.
Excel |
Pdf
SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.
SI Normal Reports |
SI Abnormal Reports