Test Id : FC4AL
C4 Level by RIA
Method Name
A short description of the method used to perform the test
Radioimmunoassay (RIA)
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test
Aliases
Lists additional common names for a test, as an aid in searching
C4 anaphylatoxin
C4a Level
C4ades Arg Level
Complement C4a Level
Specimen Type
Describes the specimen type validated for testing
Plasma EDTA
Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Container/Tube: Lavender top (plasma gel tubes are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1.5 mL plasma
Collection Instructions:
1. Mix well.
2. Within 30 minutes of collection (preferably immediately after venipuncture), centrifuge at ambient temperature, aliquot 1.5mL of plasma into a plastic vial and freeze immediately on dry ice or at -60 C or below in an ultra-low freezer.
3. Ship frozen.
Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.
Plasma: 0.5 mL
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
| Hemolysis | Mild OK; Gross reject |
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma EDTA | Frozen | 365 days |
Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
The complement system is part of our innate immune response. It is vital to our defense against invasive microorganisms. Complement activation can occur through the classical, lectin and alternative pathway, which then converge to a common terminal pathway. Activation of the complement pathway(s) results in the generation of biologically active peptides, also known as complement split products, and referred to as anaphylatoxins (C4a, C3a, C5a) which protect us from invasive microorganisms by enhancing inflammation, facilitating the clearance of immune complexes and apoptotic cells, enhancing cellular and antibody immune responses and altering vascular permeability, as well as smooth muscle contractility.
The anaphylatoxin C4a can be elevated above normal levels in many conditions associated with inflammation, including chronic fatigue syndrome, multiple sclerosis, immune complex diseases such as antiphospholipid syndrome and autoimmune conditions such as lupus. C4a is also an early marker of acute Lyme disease.
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
0-2830 ng/mL
Interpretation
Provides information to assist in interpretation of the test results
Elevated C4a levels are indicative of classical and/or lectin pathway activation.
PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information
Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.
Monday through Friday
Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
Performing Laboratory Location
Indicates the location of the laboratory that performs the test
Fees :
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Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
The performance characteristics for this test have been validated by National Jewish Health. It has not been cleared or approved by the U.S. Food and Drug Administration. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high complexity clinical laboratory testing.
CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
CPT codes are provided by the performing laboratory.
CPT codes are provided by the performing laboratory.
86160
LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
| Test Id | Test Order Name | Order LOINC Value |
|---|---|---|
| FC4AL | C4a Level | Not Provided |
| Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
|---|---|---|
| FC4AL | C4a Level | Not Provided |