Test Id : FSCPR
Scleroderma Comprehensive Profile
Reflex Tests
Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.
| Test Id | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| FANTP | ANA Titer and Pattern | No | No |
| FCA70 | Repeat Anti Scl-70 | No | No |
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
If Anti-Scl-70 Ab is >=20, Repeat Anti Scl-70 Is performed at an additional charge. If Anti-Nuclear Ab by IFA is positive, reflex test ANA Titer and Pattern is added at no additional charge.
Method Name
A short description of the method used to perform the test
RIPA Gel Radiography
Immunofluorescence Antibody
Enzyme-linked immunosorbent assay (ELISA)
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test
Aliases
Lists additional common names for a test, as an aid in searching
FSCPR
SCL Panel
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
If Anti-Scl-70 Ab is >=20, Repeat Anti Scl-70 Is performed at an additional charge. If Anti-Nuclear Ab by IFA is positive, reflex test ANA Titer and Pattern is added at no additional charge.
Specimen Type
Describes the specimen type validated for testing
Serum
Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Collection Container/Tube: 10 mL Red
Submission Container/Tube: Plastic vial
Specimen Volume: 3 mL
Acceptable: SST
Collection Instructions: Draw blood in a plain red-top tube(s), serum gel tube is acceptable. Spin down and send 3 mL of serum refrigerated in a plastic vial.
Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.
1 mL (volume does not allow for repeat testing
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
| Gross hemolysis: | Reject |
| Thawing: | Warm OK; Cold OK |
| Gross lipemia: | Reject |
| Gross icterus | Reject |
| Other: | Anything other than serum; bacterial contamination |
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Ambient | 7 days | ||
| Frozen | 60 days |
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
If Anti-Scl-70 Ab is >=20, Repeat Anti Scl-70 Is performed at an additional charge. If Anti-Nuclear Ab by IFA is positive, reflex test ANA Titer and Pattern is added at no additional charge.
Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Anti-U1 RNP Abs can be found in 2-14% of limited SSC and 5% of diffuse SSc. They are associated with isolated pulmonary arterial hypertension, arthritis and esophageal dysfunction. Anti-Th/To Abs are present in 2-6% of patients with limited SSc and are rarely found in diffuse SSc. They have specificity and are associated with isolated pulmonary arterial HTN, pulmonary fibrosis and renal crisis.
Anti-U3 RNP (Fibrillarin) Abs are highly specific for diffuse SSc with a sensitivity of 4-10%. They are associated with isolated arterial hypertension, myositis, renal and cardiac manifestations of SSc.
Anti-PM/SCL Abs are found in 25% of Scleroderma/myositis overlap, 10% of idiopathic inflammatory myopathy and 2% of Scleroderma cutaneous changes and ILD.
Anti-RNA Polymerase III Abs are useful in the diagnosis of SSc and for the identification of patients at risk for developing renal crisis, progressive skin thickening and cancer. The prevalence of IgG RNAP III antibodies is 20-35% in diffuse SSC and 9% in limited SSc.
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Anti-Nuclear Ab by IFA, Anti-U3 RNP(Fibrillarin), Anti-Th/To Ab:
Reference Range: Negative
Anti-Centromere Ab:
Reference Range: <1:40
Anti-SCL-70 Ab:
Reference Range: <20
Anti-RNA Polymerase III, Anti-U1RNP Ab, and Anti-PM/Scl-100 Ab:
Reference Range: <20
Negative: <20 units
Weak Positive: 20-39 units
Moderate Positive: 40-80 units
Strong Positive:
PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information
Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.
Monday through Friday
Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
Performing Laboratory Location
Indicates the location of the laboratory that performs the test
Fees :
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
- Authorized users can sign in to Test Prices for detailed fee information.
- Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
- Prospective clients should contact their account representative. For assistance, contact Customer Service.
Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
CPT codes are provided by the performing laboratory.
CPT codes are provided by the performing laboratory.
86038
83516
86235 x 5
86256
LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
| Test Id | Test Order Name | Order LOINC Value |
|---|---|---|
| FSCPR | Scleroderma Comp Profile | Not Provided |
| Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
|---|---|---|
| Z5784 | Anti-Nuclear Ab by IFA | Not Provided |
| Z5785 | Anti-Centromere Ab | Not Provided |
| Z5786 | Anti-RNA Polymerase III | Not Provided |
| Z5787 | Anti-Scl-70 Ab | Not Provided |
| Z5788 | Anti-U1 RNP Ab | Not Provided |
| Z5789 | Anti-U3 RNP (Fibrillarin) | Not Provided |
| Z5790 | Anti-Th/To Ab | Not Provided |
| Z5791 | Anti-PM/Scl-100 Ab | Not Provided |