Test Catalog

Test Id : FBUMT

Bupropion and Metabolite, Serum

Method Name
A short description of the method used to perform the test

High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)

NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test

Bupropion and Metabolite, S

Lists additional common names for a test, as an aid in searching

Bupropion Metabolite




Specimen Type
Describes the specimen type validated for testing

Serum Red

Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Specimen Type: Serum

Container/Tube: Red-top

Preferred: Red-top

Specimen volume: 1 mL

Draw blood in a plain red-top tube(s), serum gel tube is not acceptable. Spin down and send 1 mL of serum frozen in a plastic vial.

Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory

0.5 mL

Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected

Gross Hemolysis Reject
Gross Lipemia OK
Gross Icterus OK
Other Polymer gel separation tube (SST or PST)

Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen Type Temperature Time Special Container
Serum Red Frozen 30 days

Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Reporting Limit determined each analysis.

Units: ng/mL

Provides information to assist in interpretation of the test results


Maximum antidepressant response was observed at trough plasma concentrations of 50 – 100 ng/mL bupropion with virtually no response below 25 ng/mL.


Reported average bupropion peak plasma concentrations:

Adults: Single 100 mg IR – 120 +/- 10 ng/mL (Males):

150 +/- 10 ng/mL (Females)

Adults: Single 200 mg IR -220 +/- 20 ng/mL (Males):

270 +/- 20 ng/mL (Females)

Adults: Single 150 mg SR - 140 +/- 20 ng/mL

Juveniles: 100 mg/day SR for 2 weeks – 25 +/- 8 ng/mL

Juveniles: 200 mg/day SR for 2 weeks – 53 +/- 22 ng/mL


Specimens must be kept frozen. If specimens are not kept frozen, this may cause lower or negative values.



8 adults (Age 22 – 42) taking thrice daily 100 mg normal release bupropion for 2 weeks had an average peak plasma concentration of 1000 +/- 70 ng/mL hydroxybupropion.

Juvenile patients taking once daily, extended release bupropion for two weeks had the following peak plasma concentrations:

100 mg/day (n = 11), 450 +/- 210 ng/mL hydroxybupropion

200 mg/day (n = 8), 710 +/- 350 ng/mL hydroxybupropion

PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information


Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Monday through Sunday

Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.

6 to 10 days

Performing Laboratory Location
Indicates the location of the laboratory that performs the test

NMS Labs

Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.

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  • Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
  • Prospective clients should contact their account representative. For assistance, contact Customer Service.

Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.

This test was developed and its performance characteristics determined by NMS Labs. It has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.

CPT codes are provided by the performing laboratory.


LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.

Test Id Test Order Name Order LOINC Value
FBUMT Bupropion and Metabolite, S Not Provided
Result Id Test Result Name Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
Z3522 Bupropion 6706-6
Z3523 Hydroxybupropion 9418-5

Test Setup Resources

Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.

Excel | Pdf

Sample Reports
Normal and Abnormal sample reports are provided as references for report appearance.

Normal Reports | Abnormal Reports

SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.

SI Normal Reports | SI Abnormal Reports

Test Update Resources

Change Type Effective Date
Test Changes - Referral Fee 2022-05-01