Test Id : FHVGM
Hantavirus Antibody (IgG, IgM)
Method Name
A short description of the method used to perform the test
Immunoassay
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test
Specimen Type
Describes the specimen type validated for testing
Serum
Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions:
1. Centrifuge and aliquot 0.5 mL of serum into a plastic vial.
2. Ship refrigerated.
Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.
0.50 mL
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
| Gross Hemolysis | Reject |
| Lipemia | Reject |
| Icterus | Reject |
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Ambient | 7 days | ||
| Frozen | 30 days |
Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
This immunoassay is for the detection of IgM and IgG antibodies against Sin Nombre virus (SNV), a New World hantavirus species endemic in the United States. Laboratory testing can aid in the diagnosis of hantavirus pulmonary syndrome (HPS) in a patient with consistent signs and symptoms of infection.
Hantavirus pulmonary syndrome is caused primarily via inhalation of hantavirus from contaminated rodent urine, droppings, or saliva. Symptoms may include fatigue, fever, muscles aches, with rapid progression to coughing and shortness of breath, which may be severe and life-threatening. Testing may be considered in patients with HPS-compatible symptoms who may have had contact with rodents or infested areas.
In addition to New World hantaviruses, there are Old World hantaviruses (eg, Seoul, Hantaan, Dobrava, and Puumala) endemic to Asia and Europe that cause hemorrhagic fever with renal syndrome, a condition not typically seen in the United States. This assay may or may not detect antibodies against these Old World hantaviruses due to variable cross-reactivity with the target antigen. Negative antibody results may also occur early in infection, prior to seroconversion. Antibodies can be detected as early as the prodromal phase of infection (3-7 days). IgM results may be detected for months and IgG for up to several years after acute infection. Cross-reactivity with autoimmune conditions can occur. Therefore, the results of this test should be interpreted in the context of pertinent clinical and physical findings.
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Negative
Clinical Reference
Recommendations for in-depth reading of a clinical nature
1. Centers for Disease Control and Prevention (CDC). About Hantavirus. CDC. Updated May 13, 2024. Accessed August 22, 2025. Available at www.cdc.gov/hantavirus/about/index.html
2. Centers for Disease Control and Prevention (CDC). Clinician Brief: Hantavirus Syndrome (HPS). CDC. Updated May 23, 2024. Accessed August 22, 2025. Available at www.cdc.gov/hantavirus/hcp/clinical-overview/hps.html
3. Klena JD, Chiang CF, Whitmer SM, Wang YF, Shieh WJ. Hantaviruses. In: ClinMicroNow. doi:10.1002/9781683670438.mcm0099
4. Vial PA, Ferres M, Vial C, et al. Hantavirus in humans: a review of clinical aspects and management. Lancet Infect Dis. 2023;23(9):e371-e382. doi:10.1016/S1473-3099(23)00128-7
PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information
Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.
Wednesday
Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
Performing Laboratory Location
Indicates the location of the laboratory that performs the test
Fees :
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
- Authorized users can sign in to Test Prices for detailed fee information.
- Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
- Prospective clients should contact their account representative. For assistance, contact Customer Service.
Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
CPT codes are provided by the performing laboratory.
CPT codes are provided by the performing laboratory.
86790 x 2
LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
| Test Id | Test Order Name | Order LOINC Value |
|---|---|---|
| FHVGM | Hantavirus Antibody (IgG, IgM) | Not Provided |
| Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
|---|---|---|
| Z4933 | Hantavirus Ab (IgG) | 26620-5 |
| Z4934 | Hantavirus Ab (IgM) | 32131-5 |