Detection of drug abuse involving phencyclidine (street names: angel dust, hog, or angel hair) in urine specimens handled through the chain-of-custody process
Test Id | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
COCH | Chain of Custody Processing | No | Yes |
ADLTX | Adulterants Survey, CoC, U | Yes | Yes |
Testing for adulterants will be performed on all chain of custody urine samples per regulatory requirements.
Immunoassay/Gas Chromatography-Mass Spectrometry (GC-MS) Confirmation with Quantitation
Angel Dust (Phencyclidine)
Killer Weed (Phencyclidine)
PCP (Phencyclidine)
Rocket Fuel (Phencyclidine)
Super Weed
TCP (Phencyclidine)
Testing for adulterants will be performed on all chain of custody urine samples per regulatory requirements.
Urine
This test is for situations that require the chain-of-custody process. For testing not requiring chain of custody, order PCPU / Phencyclidine Confirmation, Random, Urine.
Supplies: Chain of Custody Kit (T282)
Container/Tube: Chain-of-Custody Kit containing the specimen containers, seals, and documentation required.
Specimen Volume: 10 mL
Collection Instructions: Collect specimen in the container provided, seal, and submit with the associated documentation to satisfy the legal requirements for chain-of-custody testing.
1. Chain of Custody Request is included in the Chain-of-Custody Kit (T282).
2. If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.
5 mL
Gross hemolysis | OK |
Gross icterus | OK |
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Urine | Refrigerated (preferred) | 14 days | |
Frozen | 14 days | ||
Ambient | 72 hours |
Detection of drug abuse involving phencyclidine (street names: angel dust, hog, or angel hair) in urine specimens handled through the chain-of-custody process
Testing for adulterants will be performed on all chain of custody urine samples per regulatory requirements.
Phencyclidine (PCP) is a drug of abuse. This compound affects diverse neural pathways and interacts with cholinergic, adrenergic, GABA-secreting, serotoninergic, opiate neuronal receptors, and gamma receptors. It has analgesic, anesthetic, and stimulatory effects, yielding bizarre behavior, ranging from depression through catatonia, euphoria, violent rage, and hallucinations. Most fatalities result from its hypertensive effect.
Diagnosis of PCP usage depends on drug screening. PCP is excreted in the urine.
Chain of custody is required whenever the results of testing could be used in a court of law. Its purpose is to protect the rights of the individual contributing the specimen by demonstrating that it was under the control of personnel involved with testing the specimen at all times; this control implies that the opportunity for specimen tampering would be limited. This includes a record of the disposition of a specimen to document the personnel who collected it, who handled it, and who performed the analysis. When a specimen is submitted in this manner, analysis will be performed in such a way that it will withstand regular court scrutiny.
Negative
Cutoff concentrations
IMMUNOASSAY SCREEN
<25 ng/mL
PHENCYCLIDINE BY GC-MS
<10 ng/mL
The presence of phencyclidine (PCP) in urine is a strong indicator that the patient has used PCP.
Urine phencyclidine (PCP) may be undetectable at alkaline pH. Urine pH must, therefore, always be recorded.
1. Schuster DI, Arnold FJ, Murphy RB: Purification, pharmacological characterization and photoaffinity labeling of sigma receptors from rat and bovine brain. Brain Res 1995;670:14-28
2. Bayorh MA, Zokowska-Grojec A, Palkovits M, Kopin IJ: Effect of phencyclidine (PCP) on blood pressure and catecholamine levels in discrete brain nuclei. Brain Res 1984;321:315-318
3. Baselt RC: Disposition of Toxic Drugs and Chemicals in Man. 11th edition. Biomedical Publications, 2017
The specimen is initially screened by immunoassay followed by gas chromatography/mass spectrometry.(Unpublished Mayo method)
Monday, Wednesday
This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.
83992
G0480 (if appropriate)
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
PCPX | Phencyclidine Confirmation, CoC, U | 16254-5 |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
6672 | Phencyclidine Immunoassay Screen | 19659-2 |
36229 | Phencyclidine-by GC/MS | 16254-5 |
36230 | Phencyclidine Interpretation | 69050-3 |
36231 | Chain of Custody | 77202-0 |