Test Id : IL1B
Interleukin-1 Beta, Plasma
Useful For
Suggests clinical disorders or settings where the test may be helpful
Measuring the concentration of interleukin-1 beta in plasma
Evaluating patients experiencing inflammatory conditions, autoinflammatory disorders, and infection
Highlights
This test may aid the evaluation and monitoring of patients experiencing inflammatory conditions, autoinflammatory disorders, and infection.
Method Name
A short description of the method used to perform the test
Bead-Based Multiplex Immunoassay
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test
Aliases
Lists additional common names for a test, as an aid in searching
Cytokine
Cytokines
IL-1 family cytokines
IL 1-Beta
IL-1
IL-1 Beta
IL1
IL1B
Interleukin 1-Beta
Interleukin 1b
Specimen Type
Describes the specimen type validated for testing
Plasma EDTA
Ordering Guidance
If this test is ordered with CYPAN / Cytokine Panel, Plasma, this test will be canceled as duplicate and CYPAN performed as ordered.
Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Lavender top (EDTA)
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions:
1. Immediately after specimen collection, place tube on wet ice.
2. Centrifuge at 4 degrees C, 1500 x g for 10 minutes.
3. Aliquot plasma into plastic vial.
4. Freeze specimen within 2 hours of collection.
Additional Information:
1. Plasma for this test cannot be shared with other tests. Submit specimen for this test in its own vial.
2. This test cannot be added on to a previously collected specimen.
Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.
0.3 mL
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
| Heat-treated specimen | Reject |
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma EDTA | Frozen | 21 days |
Useful For
Suggests clinical disorders or settings where the test may be helpful
Measuring the concentration of interleukin-1 beta in plasma
Evaluating patients experiencing inflammatory conditions, autoinflammatory disorders, and infection
Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Interleukin-1 (IL-1) beta is a potent pro-inflammatory cytokine that is crucial for host-defence responses to infection and injury. IL-1 beta binds to IL-1 receptor 1 (IL-1R1) and initiates inflammatory responses in T-lymphocytes, epithelial cells and endothelial cells.(1,2) Excess IL-1 beta signaling have been associated with acute inflammation and chronic autoinflammatory diseases.(3) Plasma IL-1 beta concentrations are elevated in some rheumatoid arthritis patients compared to healthy volunteers. There are increased concentrations of IL-1 beta and tumor necrosis factor-alpha in synovial fluid of rheumatoid arthritis patients.
Several biologics, such as anakinra and canakinumab, have been developed to inhibit the IL-1 signaling pathway by blocking IL-1 beta binding to IL-1 receptors in rheumatoid arthritis, familial Mediterranean fever, cryopyrin-associated periodic syndromes, etc.(2,4)
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
<18 years: Not established
> or =18 years: <20.0 pg/mL
Interpretation
Provides information to assist in interpretation of the test results
Elevated interleukin-1 beta concentrations could indicate the presence of inflammatory or infectious condition.
Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Results from interleukin-1 (IL-1) beta testing should not be used to establish or exclude a specific diagnosis.
Testing for IL-1 beta should only be used in conjunction with clinical information and other laboratory testing as part of a patient's overall assessment.
Normal concentration of IL-1 beta does not exclude the possibility of infection or inflammatory disorders.
Concentrations of IL-1B could be affected by immunomodulatory agents.
Clinical Reference
Recommendations for in-depth reading of a clinical nature
1. Pretre V, Papadopoulos D, Regard J, Pelletier M, Woo J. Interleukin-1 (IL-1) and the inflammasome in cancer. Cytokine. 2022;153:155850
2. Imazio M, Lazaros G, Gattorno M, et al. Anti-interleukin-1 agents for pericarditis: a primer for cardiologists. Eur Heart J. 2022;43(31):2946-2957
3. Carta S, Semino C, Sitia R, Rubartelli A. Dysregulated IL-1 beta Secretion in Autoinflammatory Diseases: A Matter of Stress?. Front Immunol. 2017;8:345
4. Kaneko N, Kurata M, Yamamoto T, Morikawa S, Masumoto J. The role of interleukin-1 in general pathology. Inflamm Regen. 2019;39:12
Method Description
Describes how the test is performed and provides a method-specific reference
Testing for interleukin-1 beta levels is performed using a laboratory-developed bead-based immunoassay.(Unpublished Mayo method)
PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information
Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.
Tuesday
Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
Specimen Retention Time
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location
Indicates the location of the laboratory that performs the test
Fees :
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
- Authorized users can sign in to Test Prices for detailed fee information.
- Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
- Prospective clients should contact their account representative. For assistance, contact Customer Service.
Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.
CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
CPT codes are provided by the performing laboratory.
CPT codes are provided by the performing laboratory.
83520
LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
| Test Id | Test Order Name | Order LOINC Value |
|---|---|---|
| IL1B | IL-1 Beta, P | 13629-1 |
| Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
|---|---|---|
| 622327 | IL-1 beta | 13629-1 |