Test Id : CNEI
Peripheral Nervous System Comprehensive Neuropathy, Autoimmune Evaluation Interpretation, Serum (Non-Orderable)
Useful For
Suggests clinical disorders or settings where the test may be helpful
Only orderable as part of a profile. For more information see CNES / Peripheral Nervous System Comprehensive Neuropathy, Autoimmune Evaluation, Serum.
Interpretation for the Peripheral Nervous System Comprehensive Neuropathy, Autoimmune Evaluation
Method Name
A short description of the method used to perform the test
Only orderable as part of a profile. For more information see CNES / Peripheral Nervous System Comprehensive Neuropathy, Autoimmune Evaluation, Serum.
Technical Interpretation
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test
Aliases
Lists additional common names for a test, as an aid in searching
Comprehensive Neuropathy Interpretation
CNES
Specimen Type
Describes the specimen type validated for testing
Serum
Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Only orderable as part of a profile. For more information see CNES / Peripheral Nervous System Comprehensive Neuropathy, Autoimmune Evaluation, Serum.
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Ambient | 72 hours | ||
| Frozen | 28 days |
Useful For
Suggests clinical disorders or settings where the test may be helpful
Only orderable as part of a profile. For more information see CNES / Peripheral Nervous System Comprehensive Neuropathy, Autoimmune Evaluation, Serum.
Interpretation for the Peripheral Nervous System Comprehensive Neuropathy, Autoimmune Evaluation
Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
This evaluation detects autoantibodies associated with autoimmune and paraneoplastic neuropathies. The panel includes antibodies targeting peripheral nerve, dorsal root ganglia, and nodal/paranodal antigens, improving detection across diverse neuropathy phenotypes.
Reflex testing is performed to confirm and further characterize antibody reactivity, enhancing diagnostic sensitivity.
Appropriate for patients with subacute or progressive neuropathy, atypical or asymmetric presentations, autonomic involvement, or suspected immune-mediated or paraneoplastic etiologies.
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Only orderable as part of a profile. For more information see CNES / Peripheral Nervous System Comprehensive Neuropathy, Autoimmune Evaluation, Serum.
An interpretive report will be provided.
Interpretation
Provides information to assist in interpretation of the test results
The presence of specific autoantibodies and/or combinations of antibodies in this panel provides supportive evidence of an immune-mediated peripheral neuropathy. However, these results must be interpretated in the appropriate clinical context. A negative result does not exclude the possibility of an immune mediated peripheral neuropathy.
Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Negative results do not exclude a diagnosis of an immune-mediated neuropathy. Autoantibody results should always be correlated with the clinical phenotype. The use of immunotherapy prior to sample collection may result in either false positive or false negative results.
The use of immunotherapy prior to sample collection may result in either false-positive or false-negative results.
Clinical Reference
Recommendations for in-depth reading of a clinical nature
1. Shelly S, Klein CJ, Dyck PJB, et al. Neurofascin-155 immunoglobulin subtypes: Clinicopathologic associations and neurologic outcomes. Neurology. 2021;97(24): e2392-e2403
2. Dubey D, Honorat JA, Shelly S, et al. Contactin-1 autoimmunity: Serologic, neurologic, and pathologic correlates. Neurol Neuroimmunol Neuroinflamm. 2020;7(4)e771
3. Paramasivan NK, Basal E, LaFrance-Corey RG, et al. Clinical Insights Into CASPR1 and CASPR1/contactin-1 complex autoimmune nodopathies. Neurology. 2026;106(5):e214403. doi:10.1212/WNL.0000000000214403
4. Klein CJ, Triplett JD, Murray DL, et al. Optimizing anti-myelin-associated glycoprotein and IgM-gammopathy testing for neuropathy treatment evaluation. Neurology. 2024;103(11):e210000. doi:10.1212/WNL.0000000000210000
5. Dubey D, Lennon VA, Gadoth A, et al. Autoimmune CRMP5 neuropathy phenotype and outcome defined from 105 cases. Neurology. 2018;90(2):e103-e110. doi:10.1212/WNL.0000000000004803
6. Dubey D, Jitprapaikulsan J, Bi H, et al. Amphiphysin-IgG autoimmune neuropathy: A recognizable clinicopathologic syndrome. Neurology. 2019;93(20):e1873-e1880. doi:10.1212/WNL.0000000000008472
7. Dubey D. Autoimmune neuromuscular disorders associated with neural antibodies. Continuum (Minneap Minn). 2024;30(4):1136-1159. doi:10.1212/CON.0000000000001461
Method Description
Describes how the test is performed and provides a method-specific reference
An interpretation based on test results is generated by the laboratory information system.
PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information
Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.
Monday through Sunday
Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
Performing Laboratory Location
Indicates the location of the laboratory that performs the test
Fees
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
- Authorized users can sign in to Test Prices for detailed fee information.
- Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
- Prospective clients should contact their account representative. For assistance, contact Customer Service.
Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
Not Applicable
LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
| Test Id | Test Order Name | Order LOINC Value |
|---|---|---|
| CNEI | Comprehensive Neuropathy Interp, S | No LOINC Needed |
| Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
|---|---|---|
| 621106 | Comprehensive Neuropathy Interp, S | 69048-7 |
| 624190 | IFA Notes | 48767-8 |