Aiding in the diagnosis of collagenofibrotic glomerulopathy
Test Id | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
MLCPC | Microdissection, Laser Capture | No, (Bill Only) | No |
MSPTC | Mass Spectrometry | No, (Bill Only) | No |
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Collagenofibrotic Glomerulopathy
CG
GPCGMS
RBCGMSST
Special
Preliminary pathology report and history are required.
Supplies: Pathology Packaging Kit (T554)
Specimen Type: Formalin-fixed, paraffin-embedded kidney tissue block
Collection Instructions: Do not send fixed tissue slides. Testing can only be done on paraffin-embedded tissue blocks.
Fixed tissue slides Wet/frozen tissue Cytological smears Nonformalin fixed tissue Nonparaffin embedded tissue | Reject |
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Special | Ambient (preferred) | ||
Frozen | |||
Refrigerated |
Aiding in the diagnosis of collagenofibrotic glomerulopathy
Collagenofibrotic glomerulopathy (CG) also called collagen type III glomerulopathy, is a rare kidney disease characterized by large amounts of atypical type III collagen fibrils in the mesangium and subendothelial space of renal glomeruli. Liquid chromatography-tandem mass spectrometry performed on microdissected glomeruli from patients with CG demonstrates a unique proteomic profile. The presence of type III collagen, in the appropriate clinical and pathological context, can be useful to establish a diagnosis of CG.
An interpretation will be provided.
No significant cautionary statements
1. Chen X, Wan H, Xu W, Zhu J: Collagen type III glomerulopathy: Case report and review of the literature. Clin Nephrol. 2017 Jan;87:39-46. doi: 10.5414/CN108907
2. Dong J, Wei H, Han M, Guan Y, Wu Y, Li H: Collagen type III glomerulopathy: A case report and review of 20 cases. Exp Ther Med. 2015 Oct;10(4):1445-1449. doi: 10.3892/etm.2015.2695
3. Kurien AA, Larsen CP, Cossey N: Collagenofibrotic glomerulopathy. Clin Kidney J. 2015 Oct;8(5):543-547. doi: 10.1093/ckj/sfv061
4. Cohen AH: Collagen Type III Glomerulopathies. Adv Chronic Kidney Dis. 2012 Mar;19(2):101-106. doi: 10.1053/j.ackd.2012.02.017
5. Duggal R, Nada R, Rayat CS, Rane SU, Sakhuja V, Joshi K: Collagenofibrotic glomerulopathy - a review. Clin Kidney J. 2012 Feb;5(1):7-12. doi: 10.1093/ndtplus/sfr144
Affected areas are removed from paraffin-embedded tissues by laser microdissection. Protein digestion is performed, followed by liquid chromatography-tandem mass spectrometry.(Unpublished Mayo method)
Monday through Friday
This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.
82542
88380
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
MSCG | CG Confirm, LC MS | 65757-7 |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
615299 | Interpretation | 50595-8 |
615300 | Participated in the Interpretation | No LOINC Needed |
615301 | Report electronically signed by | 19139-5 |
615302 | Material Received | 81178-6 |
615303 | Disclaimer | 62364-5 |
615304 | Case Number | 80398-1 |
617019 | Gross Description | 22634-0 |
617020 | Addendum | 35265-8 |
Change Type | Effective Date |
---|---|
New Test | 2022-06-30 |