Test Id : MSCG
Collagenofibrotic Glomerulopathy Confirmation, Mass Spectrometry
Useful For
Suggests clinical disorders or settings where the test may be helpful
Aiding in the diagnosis of collagenofibrotic glomerulopathy
Reflex Tests
Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.
Test Id | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
MLCPC | Microdissection, Laser Capture | No, (Bill Only) | No |
MSPTC | Mass Spectrometry | No, (Bill Only) | No |
Method Name
A short description of the method used to perform the test
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test
Aliases
Lists additional common names for a test, as an aid in searching
Collagenofibrotic Glomerulopathy
CG
GPCGMS
RBCGMSST
Specimen Type
Describes the specimen type validated for testing
Special
Necessary Information
Preliminary pathology report, history, and electron microscopy images are required.
Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Supplies: Pathology Packaging Kit (T554)
Specimen Type: Formalin-fixed, paraffin-embedded kidney tissue block
Collection Instructions: Do not send fixed tissue slides. Testing can only be done on paraffin-embedded tissue blocks.
Forms
If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
Fixed tissue slides Wet/frozen tissue Cytological smears Nonformalin fixed tissue Nonparaffin embedded tissue | Reject |
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Special | Ambient (preferred) | ||
Refrigerated | |||
Frozen |
Useful For
Suggests clinical disorders or settings where the test may be helpful
Aiding in the diagnosis of collagenofibrotic glomerulopathy
Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Collagenofibrotic glomerulopathy (CG), also called collagen type III glomerulopathy, is a rare kidney disease characterized by large amounts of atypical type III collagen fibrils in the mesangium and subendothelial space of renal glomeruli. Liquid chromatography tandem mass spectrometry performed on microdissected glomeruli from patients with CG demonstrates a unique proteomic profile. The presence of type III collagen, in the appropriate clinical and pathological context, can be useful to establish a diagnosis of CG.
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
An interpretive report will be provided.
Interpretation
Provides information to assist in interpretation of the test results
An interpretation will be provided.
Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
No significant cautionary statements
Clinical Reference
Recommendations for in-depth reading of a clinical nature
1. Chen X, Wan H, Xu W, Zhu J. Collagen type III glomerulopathy: Case report and review of the literature. Clin Nephrol. 2017;1:39-46
2. Dong J, Wei H, Han M, Guan Y, Wu Y, Li H. Collagen type III glomerulopathy: A case report and review of 20 cases. Exp Ther Med. 2015;10(4):1445-1449
3. Kurien AA, Larsen CP, Cossey N. Collagenofibrotic glomerulopathy. Clin Kidney J. 2015;8(5):543-547
4. Cohen AH. Collagen type III glomerulopathies. Adv Chronic Kidney Dis. 2012;19(2):101-106
5. Duggal R, Nada R, Rayat CS, Sakhuja V, Joshi K. Collagenofibrotic glomerulopathy - a review. Clin Kidney J. 2012;5(1):7-12
Method Description
Describes how the test is performed and provides a method-specific reference
Affected areas are removed from paraffin-embedded tissues by laser microdissection. Protein digestion is performed, followed by liquid chromatography tandem mass spectrometry.(Unpublished Mayo method)
PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information
Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.
Monday through Friday
Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
Specimen Retention Time
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location
Indicates the location of the laboratory that performs the test
Fees :
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
- Authorized users can sign in to Test Prices for detailed fee information.
- Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
- Prospective clients should contact their account representative. For assistance, contact Customer Service.
Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.
CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
CPT codes are provided by the performing laboratory.
CPT codes are provided by the performing laboratory.
82542
88380
LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
MSCG | CG Confirm, LC MS | 65757-7 |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
615299 | Interpretation | 50595-8 |
615300 | Participated in the Interpretation | No LOINC Needed |
615301 | Report electronically signed by | 19139-5 |
615302 | Material Received | 81178-6 |
615303 | Disclaimer | 62364-5 |
615304 | Case Number | 80398-1 |
617019 | Gross Description | 22634-0 |
617020 | Addendum | 35265-8 |