Test Catalog

Test Id : MSCG

Collagenofibrotic Glomerulopathy Confirmation, Mass Spectrometry

Useful For
Suggests clinical disorders or settings where the test may be helpful

Aiding in the diagnosis of collagenofibrotic glomerulopathy

Reflex Tests
Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test Id Reporting Name Available Separately Always Performed
MLCPC Microdissection, Laser Capture No, (Bill Only) No
MSPTC Mass Spectrometry No, (Bill Only) No

Method Name
A short description of the method used to perform the test

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test

CG Confirm, LC MS

Lists additional common names for a test, as an aid in searching

Collagenofibrotic Glomerulopathy




Specimen Type
Describes the specimen type validated for testing


Necessary Information

Preliminary pathology report and history are required.

Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Supplies: Pathology Packaging Kit (T554)

Specimen Type: Formalin-fixed, paraffin-embedded kidney tissue block

Collection Instructions: Do not send fixed tissue slides. Testing can only be done on paraffin-embedded tissue blocks.

Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected

Fixed tissue slides
Wet/frozen tissue
Cytological smears
Nonformalin fixed tissue
Nonparaffin embedded tissue

Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen Type Temperature Time Special Container
Special Ambient (preferred)

Useful For
Suggests clinical disorders or settings where the test may be helpful

Aiding in the diagnosis of collagenofibrotic glomerulopathy

Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Collagenofibrotic glomerulopathy (CG) also called collagen type III glomerulopathy, is a rare kidney disease characterized by large amounts of atypical type III collagen fibrils in the mesangium and subendothelial space of renal glomeruli. Liquid chromatography-tandem mass spectrometry performed on microdissected glomeruli from patients with CG demonstrates a unique proteomic profile. The presence of type III collagen, in the appropriate clinical and pathological context, can be useful to establish a diagnosis of CG.

Provides information to assist in interpretation of the test results

An interpretation will be provided.

Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

No significant cautionary statements

Clinical Reference
Recommendations for in-depth reading of a clinical nature

1. Chen X, Wan H, Xu W, Zhu J: Collagen type III glomerulopathy: Case report and review of the literature. Clin Nephrol. 2017 Jan;87:39-46. doi: 10.5414/CN108907

2. Dong J, Wei H, Han M, Guan Y, Wu Y, Li H: Collagen type III glomerulopathy: A case report and review of 20 cases. Exp Ther Med. 2015 Oct;10(4):1445-1449. doi: 10.3892/etm.2015.2695

3. Kurien AA, Larsen CP, Cossey N: Collagenofibrotic glomerulopathy. Clin Kidney J. 2015 Oct;8(5):543-547. doi: 10.1093/ckj/sfv061

4. Cohen AH: Collagen Type III Glomerulopathies. Adv Chronic Kidney Dis. 2012 Mar;19(2):101-106. doi: 10.1053/j.ackd.2012.02.017

5. Duggal R, Nada R, Rayat CS, Rane SU, Sakhuja V, Joshi K: Collagenofibrotic glomerulopathy - a review. Clin Kidney J. 2012 Feb;5(1):7-12. doi: 10.1093/ndtplus/sfr144

Method Description
Describes how the test is performed and provides a method-specific reference

Affected areas are removed from paraffin-embedded tissues by laser microdissection. Protein digestion is performed, followed by liquid chromatography-tandem mass spectrometry.(Unpublished Mayo method)

PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information


Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Monday through Friday

Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.

7 to 15 days

Specimen Retention Time
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded

Until reported

Performing Laboratory Location
Indicates the location of the laboratory that performs the test


Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.

  • Authorized users can sign in to Test Prices for detailed fee information.
  • Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
  • Prospective clients should contact their Regional Manager. For assistance, contact Customer Service.

Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.

CPT codes are provided by the performing laboratory.



LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.

Test Id Test Order Name Order LOINC Value
MSCG CG Confirm, LC MS 65757-7
Result Id Test Result Name Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
615299 Interpretation 50595-8
615300 Participated in the Interpretation No LOINC Needed
615301 Report electronically signed by 19139-5
615302 Material Received 81178-6
615303 Disclaimer 62364-5
615304 Case Number 80398-1
617019 Gross Description 22634-0
617020 Addendum 35265-8

Test Setup Resources

Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.

Excel | Pdf

Sample Reports
Normal and Abnormal sample reports are provided as references for report appearance.

Normal Reports | Abnormal Reports

SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.

SI Normal Reports | SI Abnormal Reports

Test Update Resources

Change Type Effective Date
New Test 2022-06-30