Incorporating and summarizing subsequent results into an overall evaluation if 1 or more molecular tests are reflexed on the HAEV1 / Hemolytic Anemia Evaluation, Blood panel
This test is an additional consultative interpretation that summarizes all testing as well as any pertinent clinical information, and will be provided after all tests are completed to incorporate subsequent results into an overall evaluation if 1 or more of the following molecular tests are reflexed on the HAEV1 / Hemolytic Anemia Evaluation, Blood:
-ATHAL / Alpha-Globin Gene Analysis, Varies
-WASQR / Alpha-Globin Gene Sequencing, Blood
-WBSQR / Beta-Globin Gene Sequencing, Blood
-WBDDR / Beta-Globin Cluster Locus Deletion/Duplication, Blood
-WGSQR / Gamma-Globin Full Gene Sequencing, Varies
This summary is in addition to interpretations that may be provided for individual components.
Only orderable as a reflex. For more information see HAEV1 / Hemolytic Anemia Evaluation, Blood.
Medical Interpretation
This test is an additional consultative interpretation that summarizes all testing as well as any pertinent clinical information, and will be provided after all tests are completed to incorporate subsequent results into an overall evaluation if 1 or more of the following molecular tests are reflexed on the HAEV1 / Hemolytic Anemia Evaluation, Blood:
-ATHAL / Alpha-Globin Gene Analysis, Varies
-WASQR / Alpha-Globin Gene Sequencing, Blood
-WBSQR / Beta-Globin Gene Sequencing, Blood
-WBDDR / Beta-Globin Cluster Locus Deletion/Duplication, Blood
-WGSQR / Gamma-Globin Full Gene Sequencing, Varies
This summary is in addition to interpretations that may be provided for individual components.
Whole Blood EDTA
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Whole Blood EDTA | Refrigerated |
Incorporating and summarizing subsequent results into an overall evaluation if 1 or more molecular tests are reflexed on the HAEV1 / Hemolytic Anemia Evaluation, Blood panel
This test is an additional consultative interpretation that summarizes all testing as well as any pertinent clinical information, and will be provided after all tests are completed to incorporate subsequent results into an overall evaluation if 1 or more of the following molecular tests are reflexed on the HAEV1 / Hemolytic Anemia Evaluation, Blood:
-ATHAL / Alpha-Globin Gene Analysis, Varies
-WASQR / Alpha-Globin Gene Sequencing, Blood
-WBSQR / Beta-Globin Gene Sequencing, Blood
-WBDDR / Beta-Globin Cluster Locus Deletion/Duplication, Blood
-WGSQR / Gamma-Globin Full Gene Sequencing, Varies
This summary is in addition to interpretations that may be provided for individual components.
The evaluation of patients with hemolytic anemia can be very complex and involves incorporation of not only testing, but integration of clinical and peripheral blood findings. Nonimmune hemolytic anemia can be due to many causes, including abnormalities in the hemoglobin molecule, RBC membrane/cytoskeleton, or RBC enzyme cascade. If the evaluation of nonimmune hemolytic anemia utilizes the reflex molecular tests, a summary interpretation will be added to summarize the genetic, protein, peripheral blood, and clinical findings (if provided) will be added. This is beneficial to the ordering provider.
Only orderable as a reflex. For more information see HAEV1 / Hemolytic Anemia Evaluation, Blood.
An interpretation report will be provided.
An interpretive report will be provided that summarizes all testing as well as any pertinent clinical information.
No significant cautionary statements
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2. Beutler E: Glucose-6-phosphate dehydrogenase deficiency and other enzyme abnormalities. In: Beutler E, Lichtman MA, Collar BS, Kipps TJ, eds. Hematology. 5th ed. McGraw-Hill Book Company; 1995:564-581
3. Hoyer JD, Hoffman DR: The thalassemia and hemoglobinopathy syndromes. In: McClatchey KD, ed. Clinical Laboratory Medicine. 2nd ed. Lippincott, Williams and Wilkin;, 2002:866-895
4. King MJ, Garcon L, Hoyer JD, et al, International Council for Standardization in Haematology: ICSH guidelines for the laboratory diagnosis of nonimmune hereditary red cell membrane disorders. Int J Lab Hematol. 2015 Jun;37(3):304-325
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8. Glader B: Hereditary hemolytic anemias due to red blood cell enzyme disorders. In: Greer JP, Arber DA, Glader B, et al, eds Wintrobe's Clinical Hematology. 13th ed. Wolters Kluwer/Lippincott, Williams and Wilkins; 2014:728
9. Kipp BR, Roellinger SE, Lundquist PA, Highsmith WE, Dawson DB: Development and clinical implementation of a combination deletion PCR and multiplex ligation-dependent probe amplification assay for detecting deletions involving the human alpha-globin gene cluster. J Mol Diagn. 2011 Sep;13(5):549-557 doi: 10.1016/j.jmoldx.2011.04.001
10. Harteveld CL, Higgs DR: Alpha-thalassemia. Orphanet J Rare Dis. 2010;5:13
11. Thein SL: The molecular basis of beta-thalassemia. Cold Spring Harb Persepct Med. 2013;1;3(5):a011700
12. Hein MS, Oliveira JL, Swanson KC, et al: Large deletions involving the beta globin gene complex: genotype-phenotype correlation of 119 cases. Blood. 2015;126:3374
13. Gallagher PG: Diagnosis and management of rare congenital nonimmune hemolytic disease. Hematology Am Soc Hematol Educ Program. 2015; 2015:392-399
14. Koralkova P, van Solinge WW, van Wijk R: Rare hereditary red blood cell enzymopathies associated with hemolytic anemia - pathophysiology, clinical aspects, and laboratory diagnosis. Int J Lab Hematol. 2014 Jun;36(3):388-397
A hematopathologist evaluates all of the testing performed and a summary interpretive report is added.
Monday through Friday
Not Applicable
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
HAEV0 | Hemolytic Anemia Summary Interp | In Process |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
608090 | Hemolytic Anemia Summary Interp | 14869-2 |
608115 | Reviewed By | 18771-6 |