Incorporating and summarizing subsequent results into an overall evaluation if 1 or more molecular tests are reflexed on the MEV1 / Methemoglobinemia Evaluation
This test is an additional consultative interpretation that summarizes all testing as well as any pertinent clinical information, and will be provided after test completion to incorporate subsequent molecular results into an overall evaluation if 1 or more of the following molecular tests are reflexed on the MEV1 / Methemoglobinemia Evaluation:
-ATHAL / Alpha-Globin Gene Analysis, Varies
-WASQR / Alpha-Globin Gene Sequencing, Blood
-WBSQR / Beta-Globin Gene Sequencing, Blood
-WBDDR / Beta-Globin Cluster Locus Deletion/Duplication, Blood
-WGSQR / Gamma-Globin Full Gene Sequencing, Varies
This summary is in addition to interpretations that may be provided for each component.
Only orderable as a reflex. For more information see MEV1 / Methemoglobinemia Evaluation.
Medical Interpretation
This test is an additional consultative interpretation that summarizes all testing as well as any pertinent clinical information, and will be provided after test completion to incorporate subsequent molecular results into an overall evaluation if 1 or more of the following molecular tests are reflexed on the MEV1 / Methemoglobinemia Evaluation:
-ATHAL / Alpha-Globin Gene Analysis, Varies
-WASQR / Alpha-Globin Gene Sequencing, Blood
-WBSQR / Beta-Globin Gene Sequencing, Blood
-WBDDR / Beta-Globin Cluster Locus Deletion/Duplication, Blood
-WGSQR / Gamma-Globin Full Gene Sequencing, Varies
This summary is in addition to interpretations that may be provided for each component.
Whole Blood EDTA
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Whole Blood EDTA | Refrigerated |
Incorporating and summarizing subsequent results into an overall evaluation if 1 or more molecular tests are reflexed on the MEV1 / Methemoglobinemia Evaluation
This test is an additional consultative interpretation that summarizes all testing as well as any pertinent clinical information, and will be provided after test completion to incorporate subsequent molecular results into an overall evaluation if 1 or more of the following molecular tests are reflexed on the MEV1 / Methemoglobinemia Evaluation:
-ATHAL / Alpha-Globin Gene Analysis, Varies
-WASQR / Alpha-Globin Gene Sequencing, Blood
-WBSQR / Beta-Globin Gene Sequencing, Blood
-WBDDR / Beta-Globin Cluster Locus Deletion/Duplication, Blood
-WGSQR / Gamma-Globin Full Gene Sequencing, Varies
This summary is in addition to interpretations that may be provided for each component.
Hemoglobin variants can be associated with increased measured levels of methemoglobin and sulfhemoglobin. Some hemoglobin disorders can be very complex and involve abnormalities of the alpha, beta, delta, and gamma genes. These abnormalities can be due to, not only to point alterations, but also deletions within 1 or more globin genes. Multiple genetic variants can be seen in the same patient, and molecular testing is necessary to fully evaluate such cases.
A summary interpretation that incorporates all of the testing performed is beneficial to the ordering physician.
Only orderable as a reflex. For more information see MEV1 / Methemoglobinemia Evaluation.
An interpretive report will be provided.
An interpretive report will be provided that summarizes all testing as well as any pertinent clinical information.
No significant cautionary statements.
1. Beutler E: Methemoglobinemia and sulfhemoglobinemia. In: Beutler E, Lichtman MA, Caller BS, Kipps TJ, eds. Hematology. 5th edition. McGraw-Hill Book Company; 1995:654-663
2. Harteveld CL, Higgs DR: Alpha-thalassemia. Orphanet J Rare Dis. 2010;5:13
3. Thein SL: The molecular basis of beta-thalassemia. Cold Spring Harb Persepct Med. 2013;1;3(5):a011700
4. Crowley MA, Mollan TL, Abdulmalik OY, et al: A hemoglobin variant associated with neonatal cyanosis and anemia. N Engl J Med. 2011;364:1837-1843
5. Harteveld CL, Voskamp A, Phylipsen M, et al: Nine unknown rearrangements in 16p13.3 and 11p15.4 causing alpha- and beta-thalassaemia characterized by high resolution multiplex ligation-dependent probe amplification. J Med Genet. 2005;42:922-931
6. Hein MS, Oliveira JL, Swanson KC, et al: Large deletions involving the beta globin gene complex: genotype-phenotype correlation of 119 cases. Blood. 2015;126:3374
A hematopathologist evaluates all of the testing performed and a summary interpretive report is added.
Monday through Friday
Not Applicable
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
MEV0 | Methemoglobin Summary Interp | In Process |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
608089 | Methemoglobin Summary Interp | 59465-5 |
608114 | Reviewed By | 18771-6 |