Detecting the presence and titer of a specific factor inhibitor directed against coagulation factor VIII.
This test is not useful for the detection of a lupus-like circulating anticoagulant inhibitor, a nonspecific circulating anticoagulant, or other inhibitors that are not specific for coagulation factors.
If the factor VIII activity assay is normal or elevated, a computer-generated interpretive comment will be provided indicating inhibitor testing is not indicated and will not be performed.
Only orderable as part of a profile. For more information see 8INHE / Factor VIII Inhibitor Evaluation, Plasma
Technical Interpretation
Factor 8 Inhibitor Profile
If the factor VIII activity assay is normal or elevated, a computer-generated interpretive comment will be provided indicating inhibitor testing is not indicated and will not be performed.
Plasma Na Cit
Only orderable as part of a profile. For more information see 8INHE / Factor VIII Inhibitor Evaluation, Plasma.
Gross Hemolysis | Reject |
Gross Lipemia | Reject |
Gross Icterus | Reject |
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Plasma Na Cit | Frozen | 14 days |
Detecting the presence and titer of a specific factor inhibitor directed against coagulation factor VIII.
This test is not useful for the detection of a lupus-like circulating anticoagulant inhibitor, a nonspecific circulating anticoagulant, or other inhibitors that are not specific for coagulation factors.
If the factor VIII activity assay is normal or elevated, a computer-generated interpretive comment will be provided indicating inhibitor testing is not indicated and will not be performed.
Factor VIII (FVIII) inhibitors are IgG antibodies directed against coagulation FVIII that typically result in development of potentially life-threatening hemorrhage. These antibodies may develop in 1 of 4 different patient populations:
-Patients with congenital FVIII deficiency (hemophilia A) in response to therapeutic infusions of factor VIII concentrate
-Elderly nonhemophiliac patients (not previously factor VIII deficient)
-Women in postpartum period
-Patients with other autoimmune illnesses
Only orderable as part of a profile. For more information see 8INHE / Factor VIII Inhibitor Evaluation, Plasma.
An interpretive report will be provided.
Occasionally, a potent lupus-like anticoagulant may cause false-positive results for a specific factor inhibitor (eg, factor VIII or IX).
1. Kasper CK: Treatment of factor VIII inhibitors. Prog Hemost Thromb 1989;9:57-86
2. Peerschke EI, Castellone DD, Ledford-Kraemer M, et al: Laboratory assessment of FVIII inhibitor titer. Am J Clin Pathol 2009;131(4):552-558
3. Pruthi RK, Nichols WL: Autoimmune factor VIII inhibitors. Curr Opin Hematol 1999;6(5):314-322
4. Laboratory Hematology Practice. Edited by K Kottke-Marchant. Wiley Blackwell Publishing, 2012
If the factor VIII activity level is normal or elevated, a computer-generated interpretive comment indicating inhibitor testing was not indicated and was not performed will be provided.(Unpublished Mayo method).
Monday through Friday
Not Applicable
85390
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
8INHT | FVIII Inhib Profile Tech Interp | 69049-5 |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
8INHT | FVIII Inhib Profile Tech Interp | 69049-5 |