Confirming or excluding the presence of lupus anticoagulant (LAC), distinguishing LAC from specific coagulation factor inhibitors and nonspecific inhibitors
Investigating a prolonged activated thromboplastin time, especially when combined with other coagulation studies
This test is not useful for the detection of antiphospholipid antibodies that do not affect coagulation tests. We recommend separate testing for serum phospholipid (cardiolipin) antibodies.
Only orderable as a reflex. For more information see ALUPP / Lupus Anticoagulant Profile, Plasma.
Medical Interpretation
APTT Mixing Studies
Coag
Dilute Russell Viper Venom Time (DRVVT)
DRVVT (Dilute Russell Viper Venom Time)
Phospholipid Antibodies
Platelet Neutralization Procedure (PNP Coag Consult)
Plasma Na Cit
Only orderable as a reflex. For more information see ALUPP / Lupus Anticoagulant Profile, Plasma.
Patient Preparation: Patient should not be receiving warfarin or heparin. If the patient is currently on warfarin or heparin, this should be noted, treatment with heparin causes false-positive results of in vitro coagulation testing for lupus anticoagulant. Coumadin treatment may impair ability to detect the more subtle varieties of lupus-like anticoagulants.
Only orderable as a reflex. For more information see ALUPP / Lupus Anticoagulant Profile, Plasma.
Gross hemolysis | Reject |
Gross lipemia | Reject |
Gross icterus | Reject |
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Plasma Na Cit | Frozen | 14 days |
Confirming or excluding the presence of lupus anticoagulant (LAC), distinguishing LAC from specific coagulation factor inhibitors and nonspecific inhibitors
Investigating a prolonged activated thromboplastin time, especially when combined with other coagulation studies
This test is not useful for the detection of antiphospholipid antibodies that do not affect coagulation tests. We recommend separate testing for serum phospholipid (cardiolipin) antibodies.
Lupus anticoagulant (LAC) is an antibody to negatively charged phospholipid that interferes with phospholipid-dependent coagulation tests.
LAC is found in, but not limited to, patients with systemic lupus erythematosus; LAC is associated with other autoimmune disorders and collagen vascular disease, and occurs in response to medications or certain infections (eg, respiratory tract infections in children) and in individuals with no obvious underlying disease.
LAC has been associated with arterial and venous thrombosis and fetal loss. Individuals with thrombocytopenia or factor II deficiency associated with LAC may be at risk for bleeding.
Only orderable as a reflex. For more information see ALUPP / Lupus Anticoagulant Profile, Plasma.
An interpretive report will be provided.
An interpretive report will be provided when testing is complete.
1. Arnout J, Vermylen J: Current status and implications of autoimmune antiphospholipid antibodies in relation to thrombotic disease. J of Thromb Haemost 2003 May;1(5):931-942
2. Levin JS, Branch DW, Rauch J: The antiphospholipid syndrome. New Engl J Med 2002 March 7;346(10):752-763
3. Proven A, Bartlett RP, Moder KG et al: Clinical importance of positive tests for lupus anticoagulant and anticardiolipin antibodies. Mayo Clin Proc 2004,79(4):467-475
A coagulation expert (clinician or hematopathologist) reviews the laboratory data and an interpretive report is issued.
Monday through Friday
Not Applicable
85390-26 Special Coagulation Interpretation
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
ALUPO | Lupus Anticoagulant Interp | 75882-1 |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
603185 | Reviewed by | 18771-6 |
603465 | Lupus Anticoagulant Interp | 75882-1 |