| Web: | mayocliniclabs.com |
|---|---|
| Email: | mcl@mayo.edu |
| Telephone: | 800-533-1710 |
| International: | +1 855-379-3115 |
| Values are valid only on day of printing | |
Test Id : HOLDF
Hematologic Disorders, Fluorescence In Situ Hybridization (FISH) Hold, Varies
Useful For
Suggests clinical disorders or settings where the test may be helpful
Suggests clinical disorders or settings where the test may be helpful
Processing the bone marrow or peripheral blood specimen but delaying fluorescence in situ hybridization analysis while preliminary morphologic assessment is in process
Reflex Tests
Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.
Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.
| Test Id | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| PHLDB | Probe, Each Additional (PHLDF) | No, (Bill Only) | No |
| BALPB | Probe, Each Additional (BALPF) | No, (Bill Only) | No |
| CILMB | Probe, Each Additional (CILMF) | No, (Bill Only) | No |
| EOSMB | Probe, Each Additional (EOSMF) | No, (Bill Only) | No |
| EOS3B | Probe, Tri-color (EOSMF) | No, (Bill Only) | No |
| BALMB | Probe, Each Additional (BALMF) | No, (Bill Only) | No |
| BAL3B | Probe, Tri-color (BAL) | No, (Bill Only) | No |
| BLPMB | Probe, Each Additional (BLPMF) | No, (Bill Only) | No |
| BALAB | Probe, Each Additional (BALAF) | No, (Bill Only) | No |
| MFCDB | Probe, Each Additional (MFCDF) | No, (Bill Only) | No |
| EOSDB | Probe, Each Additional (EOSDF) | No, (Bill Only) | No |
| TLPDB | Probe, Each Additional (TLPDF) | No, (Bill Only) | No |
| CILDB | Probe, Each Additional (CILDF) | No, (Bill Only) | No |
| COGBB | Probe, Each Additional (COGBF) | No, (Bill Only) | No |
| COGTB | Probe, Each Additional (COGTF) | No, (Bill Only) | No |
| COGMB | Probe, Each Additional (COGMF) | No, (Bill Only) | No |
| HEMMB | Probe, Each Additional (HEMMF) | No, (Bill Only) | No |
| MDSDB | Probe, Each Additional (MDSDF) | No, (Bill Only) | No |
| MDSMB | Probe, Each Additional (MDSMF) | No, (Bill Only) | No |
| AMLAF | Adult AML, FISH | Yes | No |
| AMLMF | AML, Specified FISH | Yes | No |
| AMLPF | Pediatric AML, FISH | Yes | No |
| BALAF | Adult ALL (B-cell), FISH | Yes | No |
| BALMF | ALL (B-cell), Specified FISH | Yes | No |
| BALPF | Pediatric ALL (B-cell), FISH | Yes | No |
| BLPMF | B-cell Lymphoma, Specified FISH | Yes | No |
| CILDF | Cong Infantile Leukemia, Diag FISH | Yes | No |
| CILMF | Cong Infantile Leukemia, Spec FISH | Yes | No |
| CLLDF | CLL, Diagnostic FISH | Yes | No |
| CLLMF | CLL, Specified FISH | Yes | No |
| COGBF | COG, ALL (B-cell), FISH | Yes | No |
| COGMF | COG, AML, FISH | Yes | No |
| COGTF | COG, ALL (T-cell), FISH | Yes | No |
| EOSDF | Chronic Eosinophilia, Diag FISH | Yes | No |
| EOSMF | Chronic Eosinophilia, Spec FISH | Yes | No |
| HEMMF | Hematologic Specified FISH | Yes | No |
| MDSDF | MDS, Diagnostic FISH | Yes | No |
| MDSMF | MDS, Specified FISH | Yes | No |
| MFCDF | Myeloma Fixed Cell, High Risk, FISH | Yes | No |
| PHLDF | Ph-like ALL(B-cell), Diag FISH | Yes | No |
| TALAF | Adult ALL (T-cell), FISH | Yes | No |
| TALMF | ALL (T-cell), Specified FISH | Yes | No |
| TALPF | Pediatric ALL (T-cell), FISH | Yes | No |
| TLPDF | T-cell Lymphoma B/BM, Diag FISH | Yes | No |
| TLPMF | T-cell Lymphoma B/BM, Spec FISH | Yes | No |
| TALAB | Probe, Each Additional (TALAF) | No, (Bill Only) | No |
| TALPB | Probe, Each Additional (TALPF) | No, (Bill Only) | No |
| TLPMB | Probe, Each Additional (TLPMF) | No | No |
| TALMB | Probe, Each Additional (TALMF) | No, (Bill Only) | No |
| AMLAB | Probe, Each Additional (AMLAF) | No, (Bill Only) | No |
| AMLMB | Probe, Each Additional (AMLMF) | No, (Bill Only) | No |
| AMLPB | Probe, Each Additional (AMLPF) | No, (Bill Only) | No |
| CLLDB | Probe, Each Additional (CLLDF) | No, (Bill Only) | No |
| CLLMB | Probe, Each Additional (CLLMF) | No, (Bill Only) | No |
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
This test is designed to hold the sample and delay fluorescence in situ hydribization (FISH) testing while preliminary morphologic assessment or flow cytometry testing is in process.
Hold policy: Upon sample receipt, the specimen will be held in the laboratory. FISH testing will not be performed unless the client contacts the laboratory and indicates that FISH testing is desired. The client must contact the Cytogenetics Laboratory at 800-533-1710 by 4 p.m. (Central time) no later than 4 business days (96 hours) after the specimen was collected. If no notification is received by this time, the order will be processed as "cancelled." Weekend communication can be deferred until Monday.
Method Name
A short description of the method used to perform the test
A short description of the method used to perform the test
Direct Preparation of Specimen
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Yes
Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test
Lists a shorter or abbreviated version of the Published Name for a test
Heme FISH Hold, B/BM
Aliases
Lists additional common names for a test, as an aid in searching
Lists additional common names for a test, as an aid in searching
FISH sample processing
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
This test is designed to hold the sample and delay fluorescence in situ hydribization (FISH) testing while preliminary morphologic assessment or flow cytometry testing is in process.
Hold policy: Upon sample receipt, the specimen will be held in the laboratory. FISH testing will not be performed unless the client contacts the laboratory and indicates that FISH testing is desired. The client must contact the Cytogenetics Laboratory at 800-533-1710 by 4 p.m. (Central time) no later than 4 business days (96 hours) after the specimen was collected. If no notification is received by this time, the order will be processed as "cancelled." Weekend communication can be deferred until Monday.
Specimen Type
Describes the specimen type validated for testing
Describes the specimen type validated for testing
Varies
Ordering Guidance
This test is designed to hold blood and bone marrow specimens only.
This test does not apply to chromosome analysis. If specimen is to be held for chromosome analysis, order HOLDC / Hematologic Disorders, Chromosome Hold, Varies.
Due to stability issues, test PCPDS / Plasma Cell Proliferative Disorder, High-Risk with Reflex Probes, Diagnostic FISH Evaluation, Bone Marrow cannot be added onto specimens held under this test.
Shipping Instructions
Advise Express Mail or equivalent if not on courier service.
Necessary Information
Provide a reason for testing with each specimen and bone marrow pathology report (if available). The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be compromised or delayed.
ORDER QUESTIONS AND ANSWERS
| Question ID | Description | Answers |
|---|---|---|
| CG666 | Reason for Referral | |
| CG667 | Specimen | |
| CG791 | Requested FISH Test |
Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Submit only 1 of the following specimens:
Preferred:
Specimen Type: Bone marrow
Container/Tube:
Preferred: Yellow top (ACD)
Acceptable: Green top (sodium heparin), lavender top (EDTA)
Specimen Volume: 1 to 2 mL
Collection Instructions: Invert several times to mix bone marrow.
Acceptable:
Specimen Type: Blood
Container/Tube:
Preferred: Yellow top (ACD)
Acceptable: Green top (sodium heparin), lavender top (EDTA)
Specimen Volume: 6 mL
Collection Instructions: Invert several times to mix blood.
Forms
If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.
Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory
Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory
Blood: 2 mL
Bone marrow: 1 mL
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
Identifies specimen types and conditions that may cause the specimen to be rejected
No specimen should be rejected.
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Varies | Ambient (preferred) | ||
| Standard | |||
Useful For
Suggests clinical disorders or settings where the test may be helpful
Suggests clinical disorders or settings where the test may be helpful
Processing the bone marrow or peripheral blood specimen but delaying fluorescence in situ hybridization analysis while preliminary morphologic assessment is in process
Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
This test is designed to hold the sample and delay fluorescence in situ hydribization (FISH) testing while preliminary morphologic assessment or flow cytometry testing is in process.
Hold policy: Upon sample receipt, the specimen will be held in the laboratory. FISH testing will not be performed unless the client contacts the laboratory and indicates that FISH testing is desired. The client must contact the Cytogenetics Laboratory at 800-533-1710 by 4 p.m. (Central time) no later than 4 business days (96 hours) after the specimen was collected. If no notification is received by this time, the order will be processed as "cancelled." Weekend communication can be deferred until Monday.
Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Fluorescence in situ hybridization (FISH) analysis using gene-specific probes is a useful methodology to detect common, recurrent chromosome abnormalities for most hematologic malignancies. Based on morphologic review of the bone marrow or peripheral blood specimen by a hematopathologist, a determination of additional appropriate testing can be made. If the specimen does not show evidence of malignancy, FISH analysis may not be necessary. Depending on the diagnosis, conventional chromosome analysis may also be more informative.
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Not applicable
Interpretation
Provides information to assist in interpretation of the test results
Provides information to assist in interpretation of the test results
If notified by the client, this test may be canceled, and a processing fee will be assessed.
If no notification to proceed with testing is received, this test will be reported as "cancelled."
Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
No significant cautionary statements
Method Description
Describes how the test is performed and provides a method-specific reference
Describes how the test is performed and provides a method-specific reference
The specimen will be held in the laboratory while preliminary morphologic assessment is in process to determine if fluorescence in situ hybridization (FISH) testing is appropriate.
PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information
Indicates whether the report includes an additional document with charts, images or other enriched information
No
Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.
Monday through Sunday
Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
4 days
Specimen Retention Time
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
4 weeks
Performing Laboratory Location
Indicates the location of the laboratory that performs the test
Indicates the location of the laboratory that performs the test
Rochester
Fees
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
- Authorized users can sign in to Test Prices for detailed fee information.
- Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
- Prospective clients should contact their Regional Manager. For assistance, contact Customer Service.
Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
Not Applicable
CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
CPT codes are provided by the performing laboratory.
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
CPT codes are provided by the performing laboratory.
CPT codes are provided by the performing laboratory.
See individual reflex tests
LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
| Test Id | Test Order Name | Order LOINC Value |
|---|---|---|
| HOLDF | Heme FISH Hold, B/BM | No LOINC Needed |
| Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
|---|---|---|
| 51836 | Result Summary | 50397-9 |
| 51838 | Interpretation | 69965-2 |
| CG666 | Reason for Referral | 42349-1 |
| CG667 | Specimen | 31208-2 |
| 51839 | Source | 31208-2 |
| CG791 | Requested FISH Test | 48767-8 |
| 51841 | Method | 85069-3 |
| 53433 | Additional Information | 48767-8 |
| 51842 | Released by | 18771-6 |
Test Setup Resources
Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.
Sample Reports
Normal and Abnormal sample reports are provided as references for report appearance.
Normal and Abnormal sample reports are provided as references for report appearance.
SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.
Test Update Resources
| Change Type | Effective Date |
|---|---|
| Test Changes - Specimen Information | 2021-12-13 |