Test Id : FMSS2
Maternal Serum Screening, Integrated, Specimen #2, Alpha Fetoprotein, hCG, Estriol, and Inhibin A
Method Name
A short description of the method used to perform the test
Quantitative Chemiluminescent Immunoassay (CLIA)
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test
Aliases
Lists additional common names for a test, as an aid in searching
MS INT-2
Sequential Maternal Screening
Specimen Type
Describes the specimen type validated for testing
Serum
Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Specimen collection must occur between 14 weeks, 0 days and 24 weeks, 6 days gestation (based on the crown-rump length). Recommended time for maternal serum screening is 16 to 18 weeks gestation. Acceptable date ranges to collect the second samples are provided in the Integrated-1 report.
Collection Container/Tube: Serum gel or red top
Submission Container/Tube: Plastic vial
Specimen Volume: 3 mL Serum
Collection Instructions:
1. As soon as possible or within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
2. Send refrigerate.
Note: This test requires that a previous first trimester specimen, FFMSS / Maternal Serum Screening, Integrated, Specimen #1, PAPP-A, NT has been performed.
Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.
Serum: 1 mL
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
| Hemolysis | Reject |
| Plasma | Reject |
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Ambient | 72 hours | ||
| Frozen | 365 days |
Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Refer to https://ltd.aruplab.com/
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
An interpretive report will be provided.
Interpretation
Provides information to assist in interpretation of the test results
An interpretive report will be provided. Part 2 must be completed in order to receive an interpretable result. If the second specimen is not received for sequential screening, the results are uninterpretable and no maternal risk will be provided.
Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
A screen interpreted as "normal" misses approximately 15% of Down syndrome, 20% of open neural tube defects and 10% of trisomy 18 cases.
Abnormal results require follow-up with targeted ultrasound, genetic counseling, and consideration of fetal diagnostic testing.
PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information
Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.
Monday through Sunday
Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
Performing Laboratory Location
Indicates the location of the laboratory that performs the test
Fees :
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
- Authorized users can sign in to Test Prices for detailed fee information.
- Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
- Prospective clients should contact their account representative. For assistance, contact Customer Service.
CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
CPT codes are provided by the performing laboratory.
CPT codes are provided by the performing laboratory.
81511
LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
| Test Id | Test Order Name | Order LOINC Value |
|---|---|---|
| FMSS2 | Maternal Serum Screen INT, Sp-2 | Not Provided |
| Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
|---|---|---|
| Z5170 | Patient's AFP | 1834-1 |
| Z5171 | MoM for AFP | 20450-3 |
| Z5172 | Patient's uE3 | 2250-9 |
| Z5173 | MoM for uE3 | 20466-9 |
| Z5174 | Patient's hCG, 2nd Trimester | 19080-1 |
| Z5175 | hCG MoM, 2nd Trimester | 20465-1 |
| Z5176 | Patient's DIA | 23883-2 |
| Z5177 | MoM for DIA | 35738-4 |
| Z5178 | PAPP-A Maternal | 32046-5 |
| Z5179 | MoM for PAPP-A | 32123-2 |
| Z5180 | Nuchal Translucency (NT) | 12146-7 |
| Z5181 | MoM for NT | 49035-9 |
| Z5182 | Nuchal Translucency (NT), Twin B | 12146-7 |
| Z5183 | MoM for NT, Twin B | 49035-9 |
| Z5184 | Maternal Screen Interpretation | 49586-1 |
| Z5185 | Maternal Age At Delivery | 21612-7 |
| Z5186 | Maternal Weight | 29463-7 |
| Z5187 | Estimated Due Date | 11778-8 |
| Z5188 | Gestational Age for Second Specimen | 18185-9 |
| Z5189 | Dating | 21299-3 |
| Z5190 | Number of Fetuses | 11878-6 |
| Z5191 | Maternal Race | 21484-1 |
| Z5192 | Insulin Req Maternal Diabetes | 44877-9 |
| Z5193 | Smoking | 64234-8 |
| Z5194 | Family Hx Neural Tube Defect | 8670-2 |
| Z5195 | Family History of Aneuploidy | 32435-0 |
| Z5196 | Specimen | 19151-0 |
| Z5197 | Crown Rump Length | 11957-8 |
| Z5198 | Crown Rump Length, Twin B | 11957-8 |
| Z5199 | Sonographer Certification Number | 49089-6 |
| Z5200 | Sonographer Name | 49088-8 |
| Z5201 | Ultrasound Date | 34970-4 |
| Z5202 | EER Maternal Serum, Integrated, Sp2 | 11526-1 |