TEST CATALOG ORDERING & RESULTS SPECIMEN HANDLING CUSTOMER SERVICE EDUCATION & INSIGHTS
Test Catalog

Test ID: TBPZA    
Susceptibility, Mycobacterium tuberculosis Complex, Pyrazinamide, Varies

Method Description Describes how the test is performed and provides a method-specific reference

This test method is based on presence or absence of growth of Mycobacterium tuberculosis in broth cultures with the presence of critical concentrations of the antimycobacterial drug pyrazinamide. One of 2 FDA-cleared platforms may be used.

 

The VersaTrek platform uses the presence or absence of a pressure increase inside broth vials containing Mycobacterium tuberculosis in the presence of critical concentrations of the antimycobacterial drug pyrazinamide. Increasing pressure indicates the presence of actively growing M tuberculosis that is resistant pyrazinamide at 300 mcg/mL. Low or undetectable pressure increases in the presence of critical drug concentration suggests a lack of M tuberculosis growth and susceptibility to pyrazinamide 300 mcg/mL.(Package insert: VersaTREK Mycobacteria Detection and Susceptibility Testing system, TREK Diagnostics, Cleveland, OH 2014)

 

The BACTEC MGIT 960 platform uses the production and measurement of fluorescence within a Mycobacterial Growth Indicator Tube (MGIT) in the presence of actively growing M tuberculosis complex isolates in the presence of critical concentration of the antimycobacterial drug pyrazinamide. Low or undetectable levels of fluorescence in the presence of critical drug concentrations suggests lack of M tuberculosis growth and susceptibility to pyrazinamide at 100 mcg/mL. Increased fluorescence suggests active growth of M tuberculosis and resistance to pyrazinamide at 100 mcg/mL.(Package insert: BACTEC MGIT 960 SIRE Kit, BD Diagnostics, Sparks, MD 2016)

PDF Report Indicates whether the report includes an additional document with charts, images or other enriched information

No

Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.

Monday through Sunday; Varies

Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.

10-15 days

Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Clinic Laboratories until the release of the test result

21 days

Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded

1 year

Performing Laboratory Location Indicates the location of the laboratory that performs the test

Rochester