Test Catalog

Test ID: SHBG    
Sex Hormone-Binding Globulin (SHBG), Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Diagnosis and follow-up of women with symptoms or signs of androgen excess (eg, polycystic ovarian syndrome and idiopathic hirsutism)


An adjunct in monitoring sex-steroid and anti-androgen therapy


An adjunct in the diagnosis of disorders of puberty


An adjunct in the diagnosis and follow-up of anorexia nervosa


An adjunct in the diagnosis of thyrotoxicosis (tissue marker of thyroid hormone excess)


A possible adjunct in diagnosis and follow-up of insulin resistance and cardiovascular and type 2 diabetes risk assessment, particularly in women


In laboratories without access to bioavailable testosterone or equilibrium dialysis-based "true" free testosterone assays, sex hormone-binding globulin measurement is crucial in cases when assessment of the free testosterone fraction (aka free androgen index or calculated free testosterone) is required. At Mayo Clinic Laboratories, both bioavailable testosterone (TTBS / Testosterone, Total and Bioavailable, Serum) and free testosterone (TGRP / Testosterone, Total and Free, Serum) measurements are available. Free testosterone (TGRP) is measured by equilibrium dialysis, obviating the need for sex hormone-binding globulin measurements to calculate free androgen fractions.

Method Name A short description of the method used to perform the test

Automated Chemiluminescent Immunometric Assay

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Sex Hormone Binding Globulin, S

Aliases Lists additional common names for a test, as an aid in searching

Sex Steroid Binding Protein (SBP)
Testosterone-Estradiol Binding Globulin (TeBG)
Testosterone-Estradiol Binding Globulin (TeBG) Performed at Mayo New England