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Test Catalog

Test ID: DYS2    
Autoimmune Dysautonomia Evaluation, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Investigating idiopathic dysautonomic symptoms

 

Directing a focused search for cancer in patients with idiopathic dysautonomia

 

Investigating autonomic symptoms that appear in the course or wake of cancer therapy and are not explainable by recurrent cancer or metastasis (detection of autoantibodies in this profile helps differentiate autoimmune dysautonomia from the effects of chemotherapy)

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
ADEIDysautonomia, Interpretation, SNoYes
GANGAChR Ganglionic Neuronal Ab, SNoYes
ANN1SAnti-Neuronal Nuclear Ab, Type 1NoYes
CS2CSCASPR2-IgG CBA, SNoYes
CRMSCRMP-5-IgG, SNoYes
DPPISDPPX Ab IFA, SNoYes
LG1CSLGI1-IgG CBA, SNoYes
PCAB2Purkinje Cell Cytoplasmic Ab Type 2NoYes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
AMPCSAMPA-R Ab CBA, SNoNo
AMPISAMPA-R Ab IF Titer Assay, SNoNo
AMPHSAmphiphysin Ab, SNoNo
AMIBSAmphiphysin Immunoblot, SNoNo
AN1BSANNA-1 Immunoblot, SNoNo
AN2BSANNA-2 Immunoblot, SNoNo
CRMWSCRMP-5-IgG Western Blot, SNoNo
DPPCSDPPX Ab CBA, SNoNo
DPPTSDPPX Ab IFA Titer, SNoNo
GABCSGABA-B-R Ab CBA, SNoNo
GABISGABA-B-R Ab IF Titer Assay, SNoNo
NMDCSNMDA-R Ab CBA, SNoNo
NMDISNMDA-R Ab IF Titer Assay, SNoNo
PC1BSPCA-1 Immunoblot, SNoNo
PCTBSPCA-Tr Immunoblot, SNoNo
PCABPPurkinje Cell Cytoplasmic Ab Type 1NoNo
PCATRPurkinje Cell Cytoplasmic Ab Type TrNoNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

If indirect immunofluorescence assay (IFA) patterns suggest collapsin response-mediator protein (CRMP)-5-IgG, then CRMP-5-IgG Western blot is performed at an additional charge.

 

If IFA patterns suggest amphiphysin antibody, then amphiphysin antibody and/or amphiphysin immunoblot is performed at an additional charge.

 

If IFA pattern suggests antineuronal nuclear antibodies (ANNA)-1 antibody, then ANNA-1 and ANNA-2 immunoblot is performed at an additional charge.

 

If IFA pattern suggests Purkinje cytoplasmic antibody (PCA)-1 antibody, then PCA-1 immunoblot is performed at an additional charge.

 

If IFA pattern suggests PCA-Tr antibody, then PCA-Tr immunoblot is performed at an additional charge.

 

If IFA pattern suggests PCA type 1or type trace, then the appropriate antibody specific IFA is performed at an additional charge.

 

If IFA pattern suggests N-methyl-D-aspartate (NMDA)-receptor, then NMDA-receptor cell-binding assay (CBA) and NMDA-receptor titer are performed at an additional charge.

 

If IFA pattern suggests alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-receptor, then AMPA-receptor CBA and AMPA-receptor titer are performed at an additional charge.

 

If IFA pattern suggests gamma-aminobutyric acid B (GABA-B)-receptor, then GABA-B-receptor CBA and GABA-B-receptor titer are performed at an additional charge.

 

If IFA pattern suggests dipeptidyl-peptidase-like protein-6 antibody (DPPX) antibody, then DPPX antibody CBA and DPPX titer are performed at an additional charge.

 

See Autoimmune Dysautonomia Evaluation Algorithm in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

AMPHS, AMPIS, ANN1S, CRMS, DPPIS, DPPTS, GABIS, NMDIS, PCAB2, PCABP, PCATR: Indirect Immunofluorescence (IFA)

 

AMPCS, CS2CS, DPPCS, GABCS, LG1CS, NMDCS: Cell Binding Assay (CBA)

 

CRMWS: Western Blot (WB)

 

AMIBS, AN1BS, AN2BS, PC1BS, PCTBS: Immunoblot (IB)

 

GANG: Radioimmunoassay (RIA)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Autoimmune Dysautonomia Eval, S

Aliases Lists additional common names for a test, as an aid in searching

ANNA (Antineuronal Nuclear Antibody)
Anti-CV2
Anti-Enteric Neuronal Antibody
Anti-Hu
Antineuronal
Cantoxin (Receptor Antibodies)
Cerebellar Antibodies
Chorea
Collapsin Response-Mediator Protein-5 Antibody (CRMP-5), Serum
Cramp-fasciculation
CRMP-5, IgG
Dorsal Root Ganglion Antibody
DPPX
dipeptidyl aminopeptidase-like protein 6
Hu Antibody
Isaacs disease
Motor End-Plate Antibody
Motor Nerve Terminal Antibodies
Myoid Antibody
Neuromuscular hyperexcitability
Neuromyotonia
Neuronal ganglionic acetylcholine receptor antibody
Neuronal Nuclear Antibody Panel
Neuronal Potassium Channel Ab
Neuronal-Anti
Paraneoplastic Antibodies
Paraneoplastic Autoantibody Evaluation
Paraneoplastic Neurological Autoimmunity
Stiff-man Syndrome
Potassium Channel Antibodies