TEST CATALOG ORDERING & RESULTS SPECIMEN HANDLING CUSTOMER SERVICE EDUCATION & INSIGHTS
Test Catalog

Test ID: EPS2    
Epilepsy, Autoimmune Evaluation, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Investigating new onset cryptogenic epilepsy with incomplete seizure control and duration of less than 2 years using serum specimens

 

Investigating new onset cryptogenic epilepsy plus 1 or more of the following accompaniments:

-Psychiatric accompaniments (psychosis, hallucinations)

-Movement disorder (myoclonus, tremor, dyskinesias)

-Headache

-Cognitive impairment/encephalopathy

-Autoimmune stigmata (personal history or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, premature graying of hair, myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus, idiopathic adrenocortical insufficiency), or multiple sclerosis

-History of cancer

-Smoking history (20+ pack years) or other cancer risk factors

-Investigating seizures occurring within the context of a subacute multifocal neurological disorder without obvious cause, especially in a patient with past or family history of cancer

-A rising autoantibody titer in a previously seropositive patient suggests cancer recurrence

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
AEPSIEpilepsy, Interpretation, SNoYes
AMPCSAMPA-R Ab CBA, SNoYes
AMPHSAmphiphysin Ab, SNoYes
AGN1SAnti-Glial Nuclear Ab, Type 1NoYes
ANN1SAnti-Neuronal Nuclear Ab, Type 1NoYes
ANN2SAnti-Neuronal Nuclear Ab, Type 2NoYes
ANN3SAnti-Neuronal Nuclear Ab, Type 3NoYes
CS2CSCASPR2-IgG CBA, SNoYes
CRMSCRMP-5-IgG, SNoYes
DPPISDPPX Ab IFA, SNoYes
GABCSGABA-B-R Ab CBA, SNoYes
GD65SGAD65 Ab Assay, SYesYes
GFAISGFAP IFA, SNoYes
LG1CSLGI1-IgG CBA, SNoYes
GL1ISmGluR1 Ab IFA, SNoYes
NMDCSNMDA-R Ab CBA, SNoYes
PCAB2Purkinje Cell Cytoplasmic Ab Type 2NoYes
PCATRPurkinje Cell Cytoplasmic Ab Type TrNoYes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
ARBIACh Receptor (Muscle) Binding AbYesNo
AGNBSAGNA-1 Immunoblot, SNoNo
AMPISAMPA-R Ab IF Titer Assay, SNoNo
AMIBSAmphiphysin Immunoblot, SNoNo
AN1BSANNA-1 Immunoblot, SNoNo
AN2BSANNA-2 Immunoblot, SNoNo
CRMWSCRMP-5-IgG Western Blot, SYesNo
DPPCSDPPX Ab CBA, SNoNo
DPPTSDPPX Ab IFA Titer, SNoNo
GABISGABA-B-R Ab IF Titer Assay, SNoNo
GFACSGFAP CBA, SNoNo
GFATSGFAP IFA Titer, SNoNo
GL1CSmGluR1 Ab CBA, SNoNo
GL1TSmGluR1 Ab IFA Titer, SNoNo
NMDISNMDA-R Ab IF Titer Assay, SNoNo
PC1BSPCA-1 Immunoblot, SNoNo
PCTBSPCA-Tr Immunoblot, SNoNo
PCABPPurkinje Cell Cytoplasmic Ab Type 1NoNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

If client requests or if indirect immunofluorescence assay (IFA) patterns suggest collapsin response-mediator protein-5-IgG (CRMP-5-IgG), then CRMP-5-IgG Western blot and acetylcholine receptor (AChR) muscle binding are performed at an additional charge.

 

If IFA patterns suggest amphiphysin antibody, then amphiphysin immunoblot is performed at an additional charge.

 

If IFA pattern suggests antiglial nuclear antibody (AGNA)-1 antibody, then AGNA-1 immunoblot is performed at an additional charge.

 

If IFA pattern suggests antineuronal nuclear antibodies (ANNA)-1 antibody, then ANNA-1 immunoblot is performed at an additional charge.

 

If IFA pattern suggests ANNA-2 antibody, then ANNA-2 immunoblot is performed at an additional charge.

 

If IFA pattern suggests Purkinje cytoplasmic antibody (PCA)-1 antibody, then PCA-1 immunoblot is performed at an additional charge.

 

If IFA pattern suggests PCA-Tr antibody, then PCA-Tr immunoblot is performed at an additional charge.

 

If IFA pattern suggests alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPA-R) antibody, and AMPA-R antibody cell-binding assay (CBA) is positive, then AMPA-R antibody IF titer assay is performed at an additional charge.

 

If AMPA-R antibody CBA is positive, then CRMP-5-IgG Western blot and AChR (muscle) binding antibody are performed at an additional charge.

 

If contactin-associated protein-like-2 (CASPR2)-receptor antibody CBA is positive, then CRMP-5-IgG Western blot, and AChR (muscle) binding antibody are performed at an additional charge.

 

If IFA pattern suggests gamma-aminobutyric acid B receptor (GABA-B-R)antibody, and GABA-B-R antibody is positive, then GABA-B-R antibody IF titer assay is performed at an additional charge.

 

If IFA pattern suggests glial fibrillary acidic protein (GFAP) antibody, then GFAP IFA titer and GFAP CBA are performed at an additional charge.

 

If IFA pattern suggests N-methyl-D-aspartate receptor (NMDA-R) antibody, and NMDA-R antibody CBA is positive, then NMDA-R antibody IF titer assay is performed at an additional charge.

 

See Epilepsy Autoimmune Evaluation Algorithm, Serum in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

AGN1S, AMPHS, AMPIS, ANN1S, ANN2S, ANN3S, CRMS, DPPIS, DPPTS, GABIS, GFAIS, GFATS, GL1IS, GL1TS, NMDIS, PCAB2, PCABP, PCATR: Indirect Immunofluorescence Assay (IFA)

AMPCS, CS2CS, DPPCS, GABCS, GFACS, GL1CS, LG1CS, NMDCS: Cell Binding Assay (CBA)

CRMWS: Western Blot (WB)

AGNBS, AMIBS, AN1BS, AN2BS, PC1BS, PCTBS: Immunoblot (IB)

ARBI, GD65S: Radioimmunoassay (RIA)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Epilepsy-Autoimmune Evaluation, S

Aliases Lists additional common names for a test, as an aid in searching

AMPA-R Ab CBA
Amphiphysin Ab
Anti-Glial Nuclear Ab, Type 1
Anti-Neuronal Nuclear Ab, Type 1
Anti-Neuronal Nuclear Ab, Type 2
Anti-Neuronal Nuclear Ab, Type 3
CASPR2-IgG
Contactin-Associated Protein-Like-2 (CASPR2)-IgG
CRMP-5-IgG
DPPX
Dipeptidyl aminopeptidase-like protein 6
EPIES
GABA-B-R Ab CBA
Glutamic Acid Decarboxylase (GAD65)
LGI1-IgG
Metabotropic glutamate receptor 1
mGluR1
NMDA-R Ab CBA
Purkinje Cell Cytoplasmic Ab Type 2
Purkinje Cell Cytoplasmic Ab Type Tr
Seizures
Spells
ACh Receptor (Muscle) Binding Ab
Leucine-Rich Glioma Inactivated Protein-1 IgG