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Test Catalog

Test ID: ENS2    
Encephalopathy, Autoimmune Evaluation, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Evaluating new onset encephalopathy (noninfectious or metabolic) comprising confusional states, psychosis, delirium, memory loss, hallucinations, movement disorders, sensory or motor complaints, seizures, dyssomnias, ataxias, nausea, vomiting, inappropriate antidiuresis, coma, dysautonomias, or hypoventilation in serum specimens

 

The following accompaniments should increase of suspicion for autoimmune encephalopathy:

-Headache

-Autoimmune stigmata (personal or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, poliosis [premature graying], myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus)

-History of cancer

-Smoking history (20+ pack years) or other cancer risk factors

-Inflammatory cerebral spinal fluid (or isolated protein elevation)

-Neuroimaging signs suggesting inflammation

 

Evaluating limbic encephalitis (noninfectious)

 

Directing a focused search for cancer

 

Investigating encephalopathy appearing in the course or wake of cancer therapy and not explainable by metastasis or drug effect

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
AEESIEncephalopathy, Interpretation, SNoYes
GANGAChR Ganglionic Neuronal Ab, SNoYes
AMPCSAMPA-R Ab CBA, SNoYes
AMPHSAmphiphysin Ab, SNoYes
AGN1SAnti-Glial Nuclear Ab, Type 1NoYes
ANN1SAnti-Neuronal Nuclear Ab, Type 1NoYes
ANN2SAnti-Neuronal Nuclear Ab, Type 2NoYes
ANN3SAnti-Neuronal Nuclear Ab, Type 3NoYes
CS2CSCASPR2-IgG CBA, SNoYes
CRMSCRMP-5-IgG, SNoYes
DPPISDPPX Ab IFA, SNoYes
GABCSGABA-B-R Ab CBA, SNoYes
GD65SGAD65 Ab Assay, SYesYes
GFAISGFAP IFA, SNoYes
LG1CSLGI1-IgG CBA, SNoYes
GL1ISmGluR1 Ab IFA, SNoYes
NMDCSNMDA-R Ab CBA, SNoYes
CCNN-Type Calcium Channel AbNoYes
CCPQP/Q-Type Calcium Channel AbNoYes
PCABPPurkinje Cell Cytoplasmic Ab Type 1NoYes
PCAB2Purkinje Cell Cytoplasmic Ab Type 2NoYes
PCATRPurkinje Cell Cytoplasmic Ab Type TrNoYes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
ARBIACh Receptor (Muscle) Binding AbYesNo
ARMOACh Receptor (Muscle) Modulating AbNoNo
AMPISAMPA-R Ab IF Titer Assay, SNoNo
ABLOTAmphiphysin Western Blot, SNoNo
CRMWSCRMP-5-IgG Western Blot, SYesNo
DPPCSDPPX Ab CBA, SNoNo
DPPTSDPPX Ab IFA Titer, SNoNo
GABISGABA-B-R Ab IF Titer Assay, SNoNo
GFACSGFAP CBA, SNoNo
GFATSGFAP IFA Titer, SNoNo
GL1CSmGluR1 Ab CBA, SNoNo
GL1TSmGluR1 Ab IFA Titer, SNoNo
NMDISNMDA-R Ab IF Titer Assay, SNoNo
WBNParaneoplastic Autoantibody WBlot,SNoNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

If indirect immunofluorescence assay (IFA) (ANNA-1, ANNA-2, PCA-1, PCA-2) is indeterminate, then paraneoplastic autoantibody Western blot is performed at an additional charge.

 

If client requests or if IFA patterns suggest CRMP-5-IgG, then CRMP-5-IgG Western blot, ACh receptor (muscle) binding antibody, and ACh receptor (muscle) modulating antibody are performed at an additional charge.

 

If IFA patterns suggest amphiphysin antibody, then amphiphysin Western blot is performed at an additional charge.

 

If IFA pattern suggests AMPA-receptor antibody, and AMPA-receptor antibody cell-binding assay (CBA) is positive, then AMPA-receptor antibody IFA titer assay is performed at an additional charge.

 

If AMPA-receptor antibody CBA is positive, then CRMP-5-IgG Western blot, ACh receptor (muscle) binding antibody, and ACh receptor (muscle) modulating antibody are performed at an additional charge.

 

If CASPR2-receptor antibody CBA is positive, then CRMP-5-IgG Western blot, ACh receptor (muscle) binding antibody, and ACh receptor (muscle) modulating antibody are performed at an additional charge.

 

If IFA pattern suggests GABA-B-receptor antibody, and GABA-B-R receptor antibody is positive, then GABA-B-R receptor antibody IFA titer assay is performed at an additional charge.

 

If IFA pattern suggests GFAP antibody, then GFAP IFA titer and GFAP CBA are performed at an additional charge.

 

If IFA pattern suggests NMDA-receptor antibody, and NMDA-receptor antibody CBA is positive, then NMDA-receptor antibody IFA titer assay is performed at an additional charge.

 

 

If IFA pattern suggests DPPX antibody, then DPPX antibody CBA and DPPX titer are performed at an additional charge.

 

If IFA pattern suggests mGluR1 antibody, then mGluR1 antibody CBA and mGluR1 titer are performed at an additional charge.

 

See Encephalopathy Autoimmune Evaluation Algorithm-Serum in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

ANN1S, ANN2S, ANN3S, PCABP, PCAB2, PCATR, AMPHS, CRMS, AGN1S, DPPIS, DPPTS, GL1IS, GLITS, GFAIS, GFATS, AMPIS, GABIS, NMDIS: Indirect Immunofluorescence Assay (IFA)

AMPCS, GABCS, NMDCS, LG1CS, CS2CS, DPPCS, GL1CS, GFACS: Cell Binding Assay (CBA)

ABLOT, CRMWS, WBN; Western Blot (WB)

CCN, CCPQ, GANG, ARBI, GD65S: Radioimmunoassay (RIA)

ARMO: Live Cell Assay (LCA)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Encephalopathy-Autoimmune Eval, S

Aliases Lists additional common names for a test, as an aid in searching

ACh Receptor (Muscle) Binding Ab
AChR Ganglionic Ab
AMPA-R Ab CBA
Amphiphysin Ab
Anti-Glial Nuclear Ab, Type 1
Anti-Neuronal Nuclear Ab, Type 1
Anti-Neuronal Nuclear Ab, Type 2
Anti-Neuronal Nuclear Ab, Type 3
Behavioral change
CASPR2-IgG
Confusion
Contactin-Associated Protein-Like-2 (CASPR2)-IgG
CRMP-5-IgG
Encephalitis
ENCES_x
GABA-B-R Ab CBA
Glutamic Acid Decarboxylase (GAD65)
Leucine-Rich Glioma Inactived Protein-1 IgG
LGI1-IgG
N-type Voltage-Gated Calcium Channel Ab
Limbic encephalitis
NMDA-R Ab CBA
P/Q-type Voltage-Gated Calcium Channel Ab
Psychosis
Purkinje Cell Cytoplasmc Ab Type Tr
Purkinje Cell Cytoplasmic Ab Type 1
Purkinje Cell Cytoplasmic Ab Type 2
Alpha-3
Alpha 3