Test Catalog

Test ID: DMS2    
Dementia, Autoimmune Evaluation, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Investigating new onset dementia and cognitive impairment plus 1 or more of the following in serum specimens:

-Rapid onset and progression

-Fluctuating course

-Psychiatric accompaniments (psychosis, hallucinations)

-Movement disorder (myoclonus, tremor, dyskinesias)

-Headache

-Autoimmune stigmata (personal history or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, poliosis [premature graying], myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus)

-Smoking history (20+ pack years) or other cancer risk factors

-History of cancer

-Inflammatory cerebrospinal fluid

-Neuroimaging findings atypical for degenerative etiology

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
ADMSIDementia, Interpretation, SNoYes
GANGAChR Ganglionic Neuronal Ab, SNoYes
AMPCSAMPA-R Ab CBA, SNoYes
AMPHSAmphiphysin Ab, SNoYes
AGN1SAnti-Glial Nuclear Ab, Type 1NoYes
ANN1SAnti-Neuronal Nuclear Ab, Type 1NoYes
ANN2SAnti-Neuronal Nuclear Ab, Type 2NoYes
ANN3SAnti-Neuronal Nuclear Ab, Type 3NoYes
CS2CSCASPR2-IgG CBA, SNoYes
CRMSCRMP-5-IgG, SNoYes
DPPISDPPX Ab IFA, SNoYes
GABCSGABA-B-R Ab CBA, SNoYes
GD65SGAD65 Ab Assay, SYesYes
GFAISGFAP IFA, SNoYes
LG1CSLGI1-IgG CBA, SNoYes
GL1ISmGluR1 Ab IFA, SNoYes
NMDCSNMDA-R Ab CBA, SNoYes
CCNN-Type Calcium Channel AbNoYes
CCPQP/Q-Type Calcium Channel AbNoYes
PCAB2Purkinje Cell Cytoplasmic Ab Type 2NoYes
PCATRPurkinje Cell Cytoplasmic Ab Type TrNoYes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
ARBIACh Receptor (Muscle) Binding AbYesNo
AMPISAMPA-R Ab IF Titer Assay, SNoNo
ABLOTAmphiphysin Western Blot, SNoNo
CRMWSCRMP-5-IgG Western Blot, SYesNo
DPPCSDPPX Ab CBA, SNoNo
DPPTSDPPX Ab IFA Titer, SNoNo
GABISGABA-B-R Ab IF Titer Assay, SNoNo
GL1CSmGluR1 Ab CBA, SNoNo
GL1TSmGluR1 Ab IFA Titer, SNoNo
NMDISNMDA-R Ab IF Titer Assay, SNoNo
WBNParaneoplastic Autoantibody WBlot,SNoNo
PCABPPurkinje Cell Cytoplasmic Ab Type 1NoNo
ARMOACh Receptor (Muscle) Modulating AbNoNo
GFACSGFAP CBA, SNoNo
GFATSGFAP IFA Titer, SNoNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

If indirect immunofluorescence assay (IFA) (ANNA-1, ANNA-2, PCA-2,) is indeterminate, then paraneoplastic autoantibody Western blot is performed at an additional charge.

 

If client requests or if IFA patterns suggest CRMP-5-IgG, then CRMP-5-IgG Western blot, ACh receptor (muscle) binding antibody, and ACh receptor (muscle) modulating antibody are performed at an additional charge.

 

If IFA patterns suggest amphiphysin antibody, then amphiphysin Western blot is performed at an additional charge.

 

If IFA pattern suggests AMPA-receptor antibody, and AMPA-receptor antibody cell-binding assay (CBA) is positive, then AMPA-receptor antibody IF titer assay is performed at an additional charge.

 

If AMPA-receptor antibody CBA is positive, then CRMP-5-IgG Western blot, ACh receptor (muscle) binding antibody, and ACh receptor (muscle) modulating antibody are performed at an additional charge.

 

If CASPR2-receptor antibody CBA is positive, then CRMP-5-IgG Western blot, ACh receptor (muscle) binding antibody, and ACh receptor (muscle) modulating antibody are performed at an additional charge.

 

If IFA pattern suggests GABA-B-receptor antibody, and GABA-B-R receptor antibody CBA is positive, then GABA-B-R receptor antibody IF titer assay is performed at an additional charge.

 

If IFA pattern suggests GFAP antibody, GFAP IFA Titer and GFAP CBA are performed at an additional charge.

 

If IFA pattern suggests NMDA-receptor antibody, and NMDA-receptor antibody CBA is positive, then NMDA-receptor antibody IF titer assay is performed at an additional charge.

 

If IFA patterns suggest PCA-1, then Purkinje cell cytoplasmic antibody Type 1 assay is performed at an additional charge.

 

If IFA pattern suggests DPPX antibody, then DPPX antibody CBA and DPPX titer are performed at an additional charge.

 

If IFA pattern suggests mGluR1 antibody, then mGluR1 antibody CBA and mGluR1 titer are performed at an additional charge.

 

See Dementia Autoimmune Evaluation Algorithm-Serum in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

ANN1S, ANN2S, ANN3S, PCABP, PCAB2, PCATR, AMPHS, CRMS, AGN1S, DPPIS, DPPTS, GL1IS, GL1TS, GFAIS, GFATS, AMPIS, GABIS, NMDIS: Indirect Immunofluorescence Assay (IFA)

AMPCS, GABCS, NMDCS, LG1CS, CS2CS, DPPCS, GL1CS, GFACS: Cell Binding Assay (CBA)

ARMO: Live Cell Assay (LCA)

ABLOT, CRMWS, WBN: Western Blot

CCN, CCPQ, GANG, ARBI, GD65S: Radioimmunoassay (RIA)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Dementia Autoimmune Eval, S

Aliases Lists additional common names for a test, as an aid in searching

ACh Receptor (Muscle) Binding Ab
AChR Ganglionic Ab
AMPA-R Ab CBA
Amphiphysin Ab
Anti-Glial Nuclear Ab, Type 1
Anti-Neuronal Nuclear Ab, Type 1
Anti-Neuronal Nuclear Ab, Type 2
Anti-Neuronal Nuclear Ab, Type 3
CASPR2-IgG
Cognitive decline
Cognitive impairment
Contactin-Associated Protein-Like-2 (CASPR2)-IgG
CRMP-5-IgG
DEMES
DPPX
dipeptidyl aminopeptidase-like protein 6
GABA-B-R Ab CBA
Glutamic Acid Decarboxylase (GAD65)
Leucine-Rich Glioma Inactivated Protein-1 IgG
LGI1-IgG
metabotropic glutamate receptor 1
mGluR1
N-type Voltage-Gated Calcium Channel Ab
NMDA-R Ab CBA
P/Q-type Voltage-Gated Calcium Channel Ab
Purkinje Cell Cytoplasmic Ab Type Tr
Purkinje Cell Cytoplasmic Ab Type 2
Alpha-3
Alpha 3