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Test Catalog

Test ID: BCLL    
IGH Somatic Hypermutation Analysis, B-Cell Chronic Lymphocytic Leukemia (B-CLL), Varies

Useful For Suggests clinical disorders or settings where the test may be helpful

Providing prognostic information in patients with newly diagnosed B-cell chronic lymphocytic leukemia

 

This test is not intended for use in providing prognostic information for patient with other B-cell neoplasms or hematopoietic tumors.

Highlights

Although the determination of variant status can be accomplished by PCR followed by Sanger sequencing, this approach only allows for analysis of single samples at a time. Next-generation sequencing (NGS) technology represents a significant improvement over existing Sanger assays by allowing for batch sample analysis and simultaneous identification of clonal IGH rearrangement, the tumor-specific rearrangement sequence, and determination of somatic variant percent.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

Polymerase Chain Reaction (PCR) and Next-Generation Sequencing

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

IGH Somatic Hypermutation in B-CLL

Aliases Lists additional common names for a test, as an aid in searching

BCLL
IGVH
IGHV
Next Gen Sequencing Test
Somatic mutation (or Hypermutation)
CLL prognosis