Test Catalog

Test ID: BCLL    
IGH Somatic Hypermutation Analysis, B-Cell Chronic Lymphocytic Leukemia (B-CLL), Varies

Useful For Suggests clinical disorders or settings where the test may be helpful

Providing prognostic information in patients with newly diagnosed B-cell chronic lymphocytic leukemia


Although the determination of mutation status can be accomplished by PCR followed by Sanger sequencing, this approach only allows for analysis of single samples at a time. Next-generation sequencing (NGS) technology (eg, using the Illumina platform) represents a significant improvement over existing Sanger assays by allowing for batch sample analysis and simultaneous identification of clonal IGH rearrangement, the tumor-specific rearrangement sequence, and determination of somatic mutation percent.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

Polymerase Chain Reaction (PCR) and Next-Generation Sequencing

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

IGH Somatic Hypermutation in B-CLL

Aliases Lists additional common names for a test, as an aid in searching

Next Gen Sequencing Test
Somatic mutation (or Hypermutation)
CLL prognosis