Test Id : DSS
Drug Screen, Prescription/Over the Counter, Serum
Useful For
Suggests clinical disorders or settings where the test may be helpful
Detection and identification of prescription or over the counter drugs frequently found in drug overdose or used with a suicidal intent
Qualitatively identifying drugs present in the specimen; quantification of identified drugs, when available, may be performed upon client request
This test is not intended for therapeutic drug monitoring or compliance testing.
This test is not intended for use in employment-related testing.
This test is not useful for drugs of abuse or illicit drug testing, including benzodiazepines, opioids, barbiturates, cocaine, amphetamine type stimulants.
Method Name
A short description of the method used to perform the test
Gas Chromatography Mass Spectrometry (GC-MS)
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test
Aliases
Lists additional common names for a test, as an aid in searching
acetaminophen
amitriptyline
amobarbital
bupropion
butabarbital
butalbital
caffeine
carbamazepine
carisoprodol
chlorpheniramine
chlorpromazine
citalopram
clomipramine
clozapine
codeine
cyclobenzaprine
dextromethorphan
diazepam
diphenhydramine
doxepin
doxylamine
fentanyl
fluoxetine
guaifenesin
ibuprofen
imipramine
lamotrigine
lidocaine
meperidine
mephobarbital
meprobamate
metaxalone
methadone
methsuximide
methylphenidate
midazolam
naproxen
nordiazepam
nortriptyline
oxcarbazepine metabolite
pentobarbital
phenobarbital
primidone
promethazine
propofol
salicylate
secobarbital
sertraline
strychnine
theophylline
thioridazine
topiramate
tramadol
trazodone
trimipramine
venlafaxine
zaleplon
zolpidem
levetiracatum
mirtazapine
Specimen Type
Describes the specimen type validated for testing
Serum Red
Ordering Guidance
This test is not performed using chain of custody. For chain-of-custody testing, order DSSX / Drug Screen, Prescription/Over the Counter, Chain of Custody, Serum.
ORDER QUESTIONS AND ANSWERS
| Question ID | Description | Answers |
|---|---|---|
| SU_DR | Suspect Drug |
Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (serum gel/SST tubes are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 2.75 mL
Collection Instructions: Within 2 hours of collection, centrifuge and aliquot serum into plastic vial.
Special Instructions
Library of PDFs including pertinent information and forms related to the test
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.
Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.
1.1 mL
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 14 days | |
| Ambient | 3 hours | ||
| Frozen | 14 days |
Useful For
Suggests clinical disorders or settings where the test may be helpful
Detection and identification of prescription or over the counter drugs frequently found in drug overdose or used with a suicidal intent
Qualitatively identifying drugs present in the specimen; quantification of identified drugs, when available, may be performed upon client request
This test is not intended for therapeutic drug monitoring or compliance testing.
This test is not intended for use in employment-related testing.
This test is not useful for drugs of abuse or illicit drug testing, including benzodiazepines, opioids, barbiturates, cocaine, amphetamine type stimulants.
Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
This test looks for a broad spectrum of prescription and over-the-counter drugs. It is designed to detect drugs that have toxic effects, as well as known antidotes or active therapies that a clinician can initiate to treat the toxic effect. The test is intended to help physicians manage an apparent overdose or intoxicated patient, or to determine if a specific set of symptoms might be due to the presence of drugs. This test is not appropriate for drugs of abuse or illicit drug testing, including benzodiazepines, opioids, barbiturates, cocaine, and amphetamine type stimulants.
Drugs of toxic significance that are not detected by this test are digoxin, lithium, and many drugs of abuse or illicit drugs, some benzodiazepines, and some opioids.
For detection limits for drugs detected in this test see Prescription and Over-the-Counter Drug Screening List and Limits of Detection.
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Drugs detected are presumptive. Additional testing may be required to confirm the presence of any drugs detected.
Interpretation
Provides information to assist in interpretation of the test results
The drugs that are detected by this test are listed in Prescription and Over-the-Counter Drug Screening List and Limits of Detection.
The pharmacology of each drug determines how the test should be interpreted. A detailed discussion of each drug is beyond the scope of this text. If a clinical interpretation is required, contact Mayo Clinic Laboratories at 800-533-1710 and ask to speak to a toxicology consultant.
Each report will indicate the drugs detected.
Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Specimens collected in serum gel tubes are not acceptable, as the drug/analyte can absorb on the gel and lead to falsely decreased concentrations.
Clinical Reference
Recommendations for in-depth reading of a clinical nature
1. Langman LJ, Bechtel LK, Holstege CP. Clinical toxicology. In: Rifai N, Chiu RWK, Young I, Burnham CAD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2023:chap 43
2. Baselt RC. Disposition of Toxic Drugs and Chemical in Man. 12th ed. Biomedical Publications; 2020
Method Description
Describes how the test is performed and provides a method-specific reference
Screening is by gas chromatography mass spectroscopy.(Unpublished Mayo method)
PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information
Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.
Monday through Sunday
Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
Specimen Retention Time
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
Performing Laboratory Location
Indicates the location of the laboratory that performs the test
Fees :
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
- Authorized users can sign in to Test Prices for detailed fee information.
- Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
- Prospective clients should contact their account representative. For assistance, contact Customer Service.
Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.
CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
CPT codes are provided by the performing laboratory.
CPT codes are provided by the performing laboratory.
80307
LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
| Test Id | Test Order Name | Order LOINC Value |
|---|---|---|
| DSS | Drug Screen, Prescription/OTC, S | 20785-2 |
| Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
|---|---|---|
| 31168 | Chain of Custody | 77202-0 |
| 31072 | Drugs detected: | 20785-2 |