Test Catalog

Test ID: PAVAL    
Paraneoplastic, Autoantibody Evaluation, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Serological evaluation of patients who present with a subacute neurological disorder of undetermined etiology, especially those with known risk factors for cancer

 

Directing a focused search for cancer

 

Investigating neurological symptoms that appear in the course of, or after, cancer therapy, and are not explainable by metastasis

 

Differentiating autoimmune neuropathies from neurotoxic effects of chemotherapy

 

Monitoring the immune response of seropositive patients in the course of cancer therapy

 

Detecting early evidence of cancer recurrence in previously seropositive patients

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
PAINTInterpretive CommentsNoYes
GANGAChR Ganglionic Neuronal Ab, SNoYes
AMPHSAmphiphysin Ab, SNoYes
AGN1SAnti-Glial Nuclear Ab, Type 1NoYes
ANN1SAnti-Neuronal Nuclear Ab, Type 1NoYes
ANN2SAnti-Neuronal Nuclear Ab, Type 2NoYes
ANN3SAnti-Neuronal Nuclear Ab, Type 3NoYes
CRMSCRMP-5-IgG, SNoYes
VGKCNeuronal (V-G) K+ Channel Ab, SNoYes
CCNN-Type Calcium Channel AbNoYes
CCPQP/Q-Type Calcium Channel AbNoYes
PCABPPurkinje Cell Cytoplasmic Ab Type 1NoYes
PCAB2Purkinje Cell Cytoplasmic Ab Type 2NoYes
PCATRPurkinje Cell Cytoplasmic Ab Type TrNoYes
STRStriational (Striated Muscle) Ab, SYesYes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
ARBIACh Receptor (Muscle) Binding AbYesNo
ARMOACh Receptor (Muscle) Modulating AbNoNo
AMPCSAMPA-R Ab CBA, SNoNo
AMPISAMPA-R Ab IF Titer Assay, SNoNo
ABLOTAmphiphysin Western Blot, SNoNo
CS2CSCASPR2-IgG CBA, SNoNo
CRMWSCRMP-5-IgG Western Blot, SYesNo
DPPCSDPPX Ab CBA, SNoNo
DPPISDPPX Ab IFA, SNoNo
DPPTSDPPX Ab IFA Titer, SNoNo
GABCSGABA-B-R Ab CBA, SNoNo
GABISGABA-B-R Ab IF Titer Assay, SNoNo
GD65SGAD65 Ab Assay, SYesNo
LG1CSLGI1-IgG CBA, SNoNo
GL1CSmGluR1 Ab CBA, SNoNo
GL1ISmGluR1 Ab IFA, SNoNo
GL1TSmGluR1 Ab IFA Titer, SNoNo
NMDCSNMDA-R Ab CBA, SNoNo
NMDISNMDA-R Ab IF Titer Assay, SNoNo
WBNParaneoplastic Autoantibody WBlot,SNoNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

If immunofluorescence assay (IFA) (ANN1S, ANN2S, PCABP, PCAB2) patterns are indeterminate, then paraneoplastic autoantibody Western blot is performed at an additional charge.

 

If IFA patterns suggest amphiphysin antibody, then amphiphysin Western blot is performed at an additional charge.

 

If IFA patterns suggest GAD65 antibody, then GAD65 antibody radioimmunoassay is performed at an additional charge.

 

If IFA pattern suggest NMDA-R, then NMDA-R antibody cell-binding assay (CBA), and/or NMDA-R antibody titer is performed at an additional charge.

 

If IFA pattern suggest AMPA-R, then AMPA-R antibody CBA and/or AMPA-R antibody titer is performed at an additional charge.

 

If IFA pattern suggest GABA-B-R, then GABA-B-R antibody CBA and/or GABA-B-R antibody titer is performed at an additional charge. 

 

If IFA pattern suggest DPPX, then DPPX antibody CBA and DPPX antibody titer is performed at an additional charge.

 

If IFA pattern suggest mGluR1, then mGluR1 antibody CBA and mGluR1 antibody titer is performed at an additional charge.

 

If VGKC is >0.00 nmol/L, then LGI1-IgG CBA and CASPR2-IgG CBA, S are performed at an additional charge.

 

If CRMP IFA is positive, then ACh receptor binding antibody, CRMP-5-IgG Western blot, and ACh receptor (muscle) modulating antibody will be performed at an additional charge.

 

If striational striated muscle antibody is 1:7,680 or greater, then ACh receptor binding antibody, CRMP-5-IgG Western blot, and ACh receptor (muscle) modulating antibody will be performed at an additional charge.

 

CRMP-5-IgG Western blot is also performed by specific request for more sensitive detection of CRMP-5-IgG. Testing should be requested in cases of subacute basal ganglionic disorders (chorea, Parkinsonism), cranial neuropathies (especially loss of vision, taste, or smell) and myelopathies.

 

The following algorithms are available in Special Instructions

-Paraneoplastic Evaluation Algorithm

-Hereditary Peripheral Neuropathy Diagnostic Algorithm

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

ANN1S, ANN2S, ANN3S, PCABP, PCAB2, PCATR, AMPHS, CRMS, AGN1S, AMPIS, NMDIS, GABIS, DPPIS, DPPTS, GL1IS, GL1TS: Indirect Immunofluorescence Assay (IFA)

STR: Enzyme-Linked Immunosorbent Assay (ELISA)

CCPQ, CCN, ARBI, GANG, VGKC, GD65S: Radioimmunoassay (RIA)

WBN, ABLOT, CRMWS: Western Blot

NMDCS, AMPCS, GABCS, LG1CS, CS2CS, DPPCS, GL1CS: Cell-Binding Assay (CBA)

ARMO: Live Cell Assay (LCA)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Paraneoplastic Autoantibody Eval, S

Aliases Lists additional common names for a test, as an aid in searching

Acetylcholine Receptor (Muscle AChR) Antibodies
AChR (Acetylcholine Receptor)
AGNA
Amphiphysin Antibody, Serum
ANNA (Antineuronal Nuclear Antibody)
Anti-CV2
Anti-Enteric Neuronal Antibody
Anti-GAD65 (Anti-Glutamic Acid Decarboxylase)
Anti-Glial Nuclear Antibody
Anti-Hu
Anti-Purkinje Cell Cytoplasmic Antibodies
Anti-Ri
Anti-Skeletal Muscle Antibodies
Anti-Yo
Antineuronal
APCA (Anti-Purkinje Cell Antibodies)
Calcium Channel Blockers
Cerebellar Antibodies
Chorea
Cramp-fasciculation
CRMP-5, IgG
Dorsal Root Ganglion Antibody
Glutamate Decarboxylase Antibodies (GAD65)
Hu Antibody
Motor End-Plate Antibody
Motor Nerve Terminal Antibodies
Muscle (Skeletal) Antibodies
Muscle Culture Antibodies
Myoid Antibody
N-Type Calcium Channel Antibody
Neuromyotonia
Neuronal Nuclear Antibody
Neuronal Nuclear Antibody Panel
Neuronal Potassium Channel Ab
Neuronal-Anti
Ovarian Cancer-Related Antibodies
P/Q Type Calcium Channel Antibody
Paraneoplastic Antibodies
Paraneoplastic Autoantibody Evaluation
Paraneoplastic Neurological Autoimmunity
PCA-1 (Purkinje Cell Cytoplasmic Antibodies)
PCA-2 (Purkinje Cell Cytoplasmic Antibodies)
PCA-Tr (Purkinje Cell Cytoplasmic Antibodies)
PCAb (Purkinje Cell Cytoplasmic Antibodies)
Potassium Channel Antibodies (specify)
Purkinje Cell Cytoplasmic Antibodies, Type 1
Purkinje Cell Cytoplasmic Antibodies, Type 2
Purkinje Cell Cytoplasmic Antibodies, Type Tr
Ri, Anti
Stiff-man Syndrome
Striational (Striated Muscle) Antibodies
VGCC (Voltage-Gated Calcium Channel) Antibodies
VGKC
VGPC
Voltage-Gated Potassium Channel Ab
Yo-Anti
Neuronal Ganglionic Acetylcholine Receptor Antibody
Cantoxin Receptor Antibodies
Collapsin Response-Mediator Protein-5 Antibody (CRMP-5)
Isaacs Disease
Neuromuscular Hyperexcitability
Purkinje Cell Cytoplasmic Antibodies
Alpha-3