Test Catalog

Test ID: GD65S    
Glutamic Acid Decarboxylase (GAD65) Antibody Assay, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Assessing susceptibility to autoimmune (type 1, insulin-dependent) diabetes mellitus and related endocrine disorders (eg, thyroiditis and pernicious anemia). Titers generally < or =0.02 nmol/L. A second islet cell antibody (IA-2) is more predictive for development of type 1 diabetes, but less frequent than glutamic acid decarboxylase (GAD65) antibody amongst diabetic patients. Insulin autoantibodies also serve as a marker of susceptibility to type 1 diabetes.


Distinguishing between patients with type 1 and type 2 diabetes. Assays for IA-2, insulin, gastric parietal cell, thyroglobulin, and thyroid peroxidase antibodies, complement GAD65 antibody in this context; titers generally < or =0.02 nmol/L.


Confirming a diagnosis of stiff-man syndrome, autoimmune encephalitis, cerebellitis, brain stem encephalitis, myelitis; titers generally > or =0.03 nmol/L


Confirming susceptibility to organ-specific neurological disorders (eg, myasthenia gravis, Lambert-Eaton syndrome); titers generally < or =0.02 nmol/L

Method Name A short description of the method used to perform the test

Immunoprecipitation Assay (LIA)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

GAD65 Ab Assay, S

Aliases Lists additional common names for a test, as an aid in searching

64K Antibody
Anti-GAD Antibodies
Anti-Glutamic Acid Decarboxylase Ab
Beta Cell Antibody
GAD65 Antibody Assay
Pancreatic Islet Cell Ab
Stiffman Syndrome
Glutamate Decarboxylase Antibodies (GAD65)