Test Id : FAU3R
Anti-U3 RNP Antibodies (Fibrillarin)
Method Name
A short description of the method used to perform the test
RIPA Gel Radiography
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test
Aliases
Lists additional common names for a test, as an aid in searching
FAU3R
Anti-U3 RNP Ab
U3 RNP
Anti-Fibrillarin AB
Specimen Type
Describes the specimen type validated for testing
Serum
Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Collection Container/Tube: 5 mL Red
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Acceptable: SST
Collection Instructions: Draw blood in a plain red-top tube(s), serum gel tube is acceptable. Spin down and send 1 mL of serum refrigerated in a plastic vial.
Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.
0.3 mL (volume does NOT allow for repeat testing)
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
| Gross hemolysis: | Reject |
| Thawing: | Warm OK; Cold OK |
| Gross lipemia: | Reject |
| Gross icterus | Reject |
| Other: | Anything other than serum; bacterial contamination |
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Ambient | 7 days | ||
| Frozen | 60 days |
Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
The U3-RNP (Fibrillarin) particle is thought to participate in the first step of preribosomal RNA processing. Anti-U3 RNP antibodies have been shown to be highly specific for patients with SSc. Anti-Fibrillarin (U3 RNP) antibodies are highly specific for diffuse SSc with a sensitivity of 4-10%. They are associated with isolated pulmonary arterial hypertension, myositis, renal and cardiac manifestations of SSc. 15% of IIM, mostly found in scleroderma/myositis overlap. Found in 4-10% of Diffuse SSc, <2% in Limited SSc, associated with isolated PAH, myositis, cardiac and renal involvement. More prevalent in African-Americans.
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Negative
PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information
Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
Performing Laboratory Location
Indicates the location of the laboratory that performs the test
Fees :
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Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
This test was developed and its characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
CPT codes are provided by the performing laboratory.
CPT codes are provided by the performing laboratory.
86235
LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
| Test Id | Test Order Name | Order LOINC Value |
|---|---|---|
| FAU3R | Anti-U3 RNP (Fibrillarin) | 49963-2 |
| Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
|---|---|---|
| FAU3R | Anti-U3 RNP (Fibrillarin) | 49963-2 |