Test Catalog

Test ID: KRASD    
Cell-free DNA KRAS 12, 13, 61,146, Blood

Useful For Suggests clinical disorders or settings where the test may be helpful

As an alternative to invasive tissue biopsies for the determination of KRAS 12, 13, 61,146 (G12A, G12C, G12D, G12R, G12S, G12V, G13D, Q61K, Q61L, Q61R, Q61H, and A146T) mutation status

 

Selection of patients with colorectal cancer who are most likely to benefit from epidermal growth factor receptor (EGFR)-targeted therapies

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

This test evaluates cell-free DNA (cfDNA) in the peripheral blood for the presence of KRAS mutations at codons 12, 13, 61, and 146 (G12A, G12C, G12D, G12R, G12S, G12V, G13D, Q61K, Q61L, Q61R, Q61H, and A146T) in patients with colorectal cancer and can be used to assess eligibility for targeted therapies.

 

This test is not validated for serial monitoring of patients with cancer. This test is also not intended as a screening test to identify cancer.

Highlights

This test provides rapid detection of KRAS mutations in colorectal cancer patients as an alternative for KRAS analysis of tissue.

 

Current data suggests that the efficacy of epidermal growth factor receptor (EGFR)-targeted therapy in colorectal cancer patients is limited to patients whose tumors do not harbor mutations in the KRAS gene.

Method Name A short description of the method used to perform the test

Digital Droplet Polymerase Chain Reaction (PCR)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

No

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

cfDNA KRAS 12, 13, 61, 146 Blood

Aliases Lists additional common names for a test, as an aid in searching

CRC
Colorectal cancer
EGFR
Epidermal growth factor receptor
Cell free DNA
cfDNA
cell-free DNA
circulating tumor DNA
liquid biopsy
KRAS WT
KRAS codon 12
KRAS codon 13
KRAS codon 61
KRAS codon 146
Circulating tumor cells
KRAS
RAS