Test Catalog

Test ID: NGSFX    
Next-Generation Sequencing, Reflex from Acute Myeloid Leukemia 4- or 11-Gene Panels, Varies

Useful For Suggests clinical disorders or settings where the test may be helpful

When a more targeted gene panel test was initially performed in our laboratory, this test allows for comprehensive reanalysis of a larger set of genes/gene regions

 

Evaluation of hematologic neoplasms, specifically of myeloid origin (eg, acute myeloid leukemia, myelodysplastic syndrome, myeloproliferative neoplasm, myelodysplastic/myeloproliferative neoplasm) at the time of diagnosis or possibly disease relapse, to help determine diagnostic classification and provide prognostic or therapeutic information for clinical management

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

This test includes next-generation sequencing to evaluate for the following 42 genes and select intronic regions: ANKRD26, ASXL1, BCOR, CALR, CBL, CEBPA, CSF3R, DDX41, DNMT3A,ELANE, ETNK1, ETV6, EZH2, FLT3, GATA1, GATA2, IDH1, IDH2, JAK2, KDM6A, KIT, KRAS, MPL, NPM1, NRAS, PHF6, PTPN11, RAD21, RUNX1, SETBP1, SH2B3, SF3B1, SRP72, SMC3, SRSF2, STAG2,TERT, TET2, TP53, U2AF1, WT1, and ZRSR2.

Highlights

 

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

Only orderable as a reflex. Reflex testing is available upon request within 6 months of original NGAMT / Next-Generation Sequencing Acute Myeloid Leukemia, Therapeutic Gene Mutation Panel (FLT3, IDH1, IDH2, TP53) or NGAML / Next-Generation Sequencing, Acute Myeloid Leukemia, 11-Gene Panel sample submission.

 

This is a bioinformatics and variant review only for the added gene regions.

 

See Targeted Genes Interrogated by OncoHeme Next-Generation Sequencing in Special Instructions for a list of the genes and exons targeted by this test. Call 800-533-1710 for assistance with ordering.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

Only orderable as a reflex. For more information see NGAMT / Next-Generation Sequencing Acute Myeloid Leukemia, Therapeutic Gene Mutation Panel (FLT3, IDH1, IDH2, TP53) or NGAML / Next-Generation Sequencing, Acute Myeloid Leukemia, 11-Gene Panel.

 

Somatic Mutation Detection by Next-Generation Sequencing (NGS)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Reflex Analysis, NGSHM

Aliases Lists additional common names for a test, as an aid in searching

ANKRD26
ASXL1
BCOR
CALR
CBL
CEBPA
CSF3R
DDX41
DNMT3A
ELANE
ETNK1
ETV6
EZH2
FLT3
GATA1
GATA2
IDH1
IDH2
JAK2
KDM6A
KIT
KRAS
MPL
Next generation sequencing of leukemia (AML) and myelodysplasia (MDS)
Next Gen Sequencing Test
NGS cancer panel, hematologic
NGS for myeloid neoplasm evaluation (MPN)
NGS hematologic malignancies
NPM1
NRAS
PHF6
PTPN11
RAD21
RUNX1
SETBP1
SH2B3
SF3B1
Somatic mutation detection by next generation sequencing (NGS), hematologic
SRP72
SMC3
SRSF2
STAG2
TERT
TET2
TP53
U2AF1
WT1
ZRSR1