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Test ID: UGTFG    
UDP-Glucuronosyl Transferase 1A1 (UGT1A1), Full Gene Sequencing, Varies

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Useful For Suggests clinical disorders or settings where the test may be helpful

Identifying individuals who are at increased risk of adverse drug reactions with drugs that are metabolized by UGT1A1, including irinotecan, atazanavir, nilotinib, pazopanib, and belinostat

 

Identifying individuals who are at risk of hyperbilirubinemia

 

Follow-up testing for individuals with a suspected UGT1A1 variant, who had negative TA repeat region testing

 

Establishing a diagnosis of Gilbert, Crigler-Najjar syndrome type I or type II

 

Establishing carrier status for Gilbert, Crigler-Najjar syndrome type I or type II

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

This is a full gene sequencing test for UGT1A1 that includes the TA repeat region of the promoter and all intron/exon boundaries. Results are interpreted for the purposes of UGT1A1 drug metabolism and hereditary hyperbilirubinemia syndromes (Gilbert syndrome and Crigler-Najjar syndrome).

Highlights

This test screens for UGT1A1 gene variants associated with increased risk of adverse drug reactions when taking UGT1A1-metabolized drugs. These drugs include irinotecan, atazanavir, nilotinib, pazopanib, and belinostat

 

This test screens for UGT1A1 gene variants associated with congenital hyperbilirubinemia conditions including Gilbert syndrome, Crigler-Najjar syndrome type I and type II

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

See UGT1A1 Test-Ordering Algorithm in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

Polymerase Chain Reaction (PCR) followed by DNA Sequence Analysis

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

UGT1A1 Full Gene Sequencing

Aliases Lists additional common names for a test, as an aid in searching

Atazanavir
Belinostat
GNT1
Irinotecan
Irinotecan glucuronidation
Irinotecan metabolism
Nilotinib
Pazopanib
Phenol/Bilirubin
UDP-Glucuronosyltransferase
UDP-Glucosyltransferase 1
UGT1A1
Uracil Glucuronyl transferase
Uridine Diphosphate Glucosyltransferase 1
Crigler-Najjar Syndrome
Gilbert Syndrome
Hyperbilirubinemia