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Test ID: DPYDG    
Dihydropyrimidine Dehydrogenase, DPYD Full Gene Sequencing, Varies

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Useful For Suggests clinical disorders or settings where the test may be helpful

Identifying individuals at increased risk of toxicity when considering 5-fluorouracil (5-FU) and capecitabine chemotherapy treatment

 

For an individual with suspected dihydropyrimidine dehydrogenase (DPD) deficiency, this test may be useful in identifying variants associated with decreased or absent DPD enzyme activity

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

This is a pharmacogenomics test associated with 5-fluorouracil and capecitabine drug sensitivity. Biallelic variation in the DPYD gene is also associated with dihydropyrimidine dehydrogenase (DPD) deficiency.(1) Individuals who have variations identified in the DPYD may benefit from genetic consultation.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

Polymerase Chain Reaction (PCR) Followed by DNA Sequence Analysis

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

DPYD Full Gene Sequencing

Aliases Lists additional common names for a test, as an aid in searching

5-Fluorouracil
5-FU
Capecitabine
DPD
DPYD