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Test Catalog

Test ID: MGLE    
Myasthenia Gravis/Lambert-Eaton Myasthenic Syndrome Evaluation, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Confirming the autoimmune basis of a defect in neuromuscular transmission (eg, myasthenia gravis [MG], Lambert-Eaton myasthenic syndrome [LEMS])

 

Distinguishing LEMS from autoimmune forms of MG

 

Providing a quantitative autoantibody baseline for future comparisons in monitoring a patient's clinical course and response to immunomodulatory treatment

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
MGLEIMG Lambert-Eaton Interpretation, SNoYes
ARBIACh Receptor (Muscle) Binding AbYesYes
CCPQP/Q-Type Calcium Channel AbNoYes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
ACMFSAChR Modulating Flow Cytometry, SNoNo
MUSKMuSK Autoantibody, SYesNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

If acetylcholine receptor (AChR)-binding antibodies are greater than 0.02 nmol/L, then AChR muscle modulating antibody will be performed at an additional charge.

 

If AChR-binding antibodies are 0.02 nmol/L or less, then muscle-specific kinase (MuSK) autoantibody will be performed at an additional charge.

 

If unable to report AChR binding antibody due to interfering substances, then AChR muscle modulating antibody will be performed at an additional charge.

 

If unable to report AChR binding antibody due to interfering substances and AChR muscle modulating antibody is negative, MuSK autoantibody will be performed at an additional charge.

 

See Myasthenia Gravis/Lambert Eaton Syndrome Diagnostic Algorithm in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

ARBI, CCPQ, MUSK: Radioimmunoassay (RIA)

ACMFS: Flow Cytometry

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

MG/LEMS Evaluation, S

Aliases Lists additional common names for a test, as an aid in searching

Acetylcholine Receptor (Muscle AChR) Antibodies
Ach Receptor Ab
AChR (Acetylcholine Receptor)
AChR Receptor Blocking Ab
Anti-Skeletal Muscle Antibodies
Binding, Blocking, and Modulating Abs
Blocking Ab
Muscle End-Plate Antibodies
MUSK
MuSK myasthenia
Myasthenia Gravis Antibodies
Myasthenia Gravis
Myoid Antibody
Thymoma
LEMS
LES
Lambert-Eaton Myasthenic syndrome
Lambert Eaton
Lambert-Eaton syndrome
P/Q
Calcium channel antibody