Test Catalog

Test ID: REVE1    
Erythrocytosis Evaluation, Whole Blood

Useful For Suggests clinical disorders or settings where the test may be helpful

Definitive, comprehensive, and economical evaluation of an individual with JAK2-negative erythrocytosis associated with lifelong sustained increased hemoglobin or hematocrit

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
REVEIErythrocytosis InterpretationNoYes
HGBCEHb Variant, A2 and F Quantitation,BYesYes
HPLCHPLC Hb Variant, BNoYes
P50POxygen Dissociation P50NoYes
CTRLP50 Shipping Control VialNoYes
MASSHb Variant by Mass Spec, BNoYes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
SDEXSickle Solubility, BYesNo
HEMPHereditary Erythrocytosis Mut, BYesNo
IEFIsoelectric Focusing, BNoNo
UNHBHb Stability, BNoNo
HPFHHb F Distribution, BNoNo
ATHALAlpha-Globin Gene AnalysisYesNo
WASQRAlpha Globin Gene Sequencing, BYes, (Order WASEQ)No
WBSQRBeta Globin Gene Sequencing, BYes, (Order WBSEQ)No
WBDDRBeta Globin Cluster Locus Del/Dup,BYes, (Order WBDD)No
WGSQRGamma Globin Full Gene SequencingYes, (Order WGSEQ)No
BPGMMBPGM Full Gene SequencingYesNo
VHLEVHL Gene Erythrocytosis MutationsYes, (Order VHLZ)No
REVE0Erythrocytosis Summary InterpNoNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This is a consultative evaluation in which the case will be evaluated at Mayo Clinic Laboratories, the appropriate tests performed at an additional charge, and the results interpreted.


This profile evaluates for hereditary (congenital) causes of erythrocytosis. Symptoms should be long-standing or familial in nature. All cases will be tested for p50 (if shipping control is received) and hemoglobin variants (cation exchange high performance liquid chromatography, capillary electrophoresis, and mass spectrometry) with an interpretative report. Additional testing is guided in a reflexive manner and may include molecular testing of the HBA1/HBA2, HBB, EPOR, VHL, EGLN1(PHD2), EPAS1(HIF2a), and BPGM genes, among others, as appropriate. See Erythrocytosis Evaluation Testing Algorithm in Special Instructions.


An additional consultative interpretation that summarizes all testing, will be provided after test completion to incorporate subsequent results into an overall evaluation if any of the following molecular tests are reflexed:

-ATHAL / Alpha-Globin Gene Analysis, Varies

-WASQR / Alpha Globin Gene Sequencing, Blood

-WBSQR / Beta-Globin Gene Sequencing, Blood

-WBDDR / Beta-Globin Cluster Locus Deletion/Duplication, Blood

-WGSQR / Gamma-Globin Full Gene Sequencing, Varies

-BPGMM / 2,3-Bisphosphoglycerate Mutase, Full Gene Sequencing Analysis, Varies

-HEMP / Hereditary Erythrocytosis Mutations, Whole Blood

-VHLE / VHL Gene, Erythrocytosis Mutation Analysis, Varies


The following are available in Special Instructions:

-Myeloproliferative Neoplasm: A Diagnostic Approach to Bone Marrow Evaluation

-Myeloproliferative Neoplasm: A Diagnostic Approach to Peripheral Blood Evaluation

-Benign Hematology Evaluation Comparison

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

REVEI, REVE0: Medical Interpretation

HGBCE: Capillary Electrophoresis

HPLC: Cation Exchange/High Performance Liquid Chromatography (HPLC)

MASS: Mass Spectrometry (MS)

P50P: Spectrophotometry/Potentiometry

IEF: Isoelectric Focusing

HPFH: Flow Cytometry

UNHB Isopropanol and Heat Stability

VHLE: Polymerase Chain Reaction (PCR) followed by DNA Sequence Analysis

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Erythrocytosis Evaluation

Aliases Lists additional common names for a test, as an aid in searching

Chuvash Polycythemia
Congenital erythrocytosis
Congenital polycythemia
Familial erythrocytosis
Familial polycythemia
Hereditary erythrocytosis
Hereditary polycythemia
High oxygen affinity hemoglobin
HOA hemoglobin
Oxygen dissociation
Primary familial erythrocytosis
Primary familial polycythemia