Test Id : EEEVI
Red Blood Cell (RBC) Enzyme Interpretation
Useful For
Suggests clinical disorders or settings where the test may be helpful
Interpretation of results for the red blood cell enzyme evaluation
Identifying defects of red cell enzyme metabolism
Evaluating patients with Coombs-negative hemolytic anemia
Method Name
A short description of the method used to perform the test
Only orderable as part of a profile. For more information see EEEV1 / Red Blood Cell (RBC) Enzyme Evaluation, Blood.
Medical Interpretation
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test
Aliases
Lists additional common names for a test, as an aid in searching
RBC Enzyme Study
Red Cell Enzymes
Specimen Type
Describes the specimen type validated for testing
Whole Blood ACD-B
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole Blood ACD-B | Refrigerated | 11 days |
Useful For
Suggests clinical disorders or settings where the test may be helpful
Interpretation of results for the red blood cell enzyme evaluation
Identifying defects of red cell enzyme metabolism
Evaluating patients with Coombs-negative hemolytic anemia
Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Erythrocyte enzyme deficiencies are inherited causes of hemolytic anemia. Some are very common, such as glucose 6-phosphate dehydrogenase (G6PD) deficiency, and others are very rare, found in only a few families around the world. Most are autosomal in inheritance, but some are sex-linked and located on the X chromosome. Most enzyme deficiencies result in chronic nonspherocytic hemolytic anemia of variable severity; however, some, such as G6PD, can be hematologically normal with episodic acute hemolysis due to a trigger event such as medications, toxins, or some foods. The red blood cell (RBC) enzymopathies do not typically show recurrent pathognomonic changes on the peripheral blood smear other than generic features of hemolytic anemia, although some such as pyruvate kinase deficiency can have echinocytes and pyrimidine 5' nucleotidase (P5NT) deficiency is associated with basophilic stippling. RBC enzyme activity levels are best evaluated as a panel as reticulocytosis can mask some deficient states and comparison to the background enzyme activity is useful.
This is a consultative evaluation of red cell enzyme activity as a potential cause of early red cell destruction.
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Only orderable as part of a profile. For more information see EEEV1 / Red Blood Cell (RBC) Enzyme Evaluation, Blood.
Definitive results and an interpretive report will be provided.
Interpretation
Provides information to assist in interpretation of the test results
A hematopathologist expert in these disorders evaluates the case and an interpretive report is issued.
Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Recent transfusion may mask the patient's intrinsic enzyme activity and cause unreliable results.
A very high white blood cell count can contribute to interference and falsely raise the activity for some enzymes.
Some enzyme deficiency disorders can be masked by reticulocytosis and comparison of activities of other red blood cell enzyme activities in this panel can be useful.
Clinical Reference
Recommendations for in-depth reading of a clinical nature
1. Koralkova P, van Solinge WW, van Wijk R. Rare hereditary red blood cell enzymopathies associated with hemolytic anemia - pathophysiology, clinical aspects, and laboratory diagnosis. Int J Lab Hematol. 2014;36(3):388-397
2. Beutler E. Glucose-6-phosphate dehydrogenase deficiency and other enzyme abnormalities. In: Beutler E, Lichtmann MA, Coller BS, Kipps TJ, eds. Hematology. 5th ed. McGraw-Hill Book Company; 1995:564-581
Method Description
Describes how the test is performed and provides a method-specific reference
A hematopathologist who is an expert in these disorders evaluates the case and an interpretive report is issued.
PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information
Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.
Monday through Friday
Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
Performing Laboratory Location
Indicates the location of the laboratory that performs the test
Fees :
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Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
Not Applicable
LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
| Test Id | Test Order Name | Order LOINC Value |
|---|---|---|
| EEEVI | Erythrocyte Enzyme Interpretation | 59466-3 |
| Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
|---|---|---|
| 608087 | Erythrocyte Enzyme Interpretation | 59466-3 |
| 608109 | Reviewed By | 18771-6 |