Test Catalog

Test ID: AATHR    
Thrombophilia Profile, Plasma and Whole Blood

Useful For Suggests clinical disorders or settings where the test may be helpful

Evaluating patients with thrombosis or hypercoagulability states


Detecting a lupus-like anticoagulant; dysfibrinogenemia; disseminated intravascular coagulation/intravascular coagulation and fibrinolysis


Detecting a deficiency of antithrombin, protein C, or protein S


Detecting activated protein C resistance (and the factor V R506Q [Leiden] variant if indicated)


Detecting the prothrombin G20210A variant

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
AATHIThrombophilia InterpretationNoYes
PTSCProthrombin Time (PT), PYes, (order PTTP)Yes
APTSCActivated Partial Thrombopl Time, PYes, (order APTTP)Yes
DRV1Dilute Russells Viper Venom Time, PYes, (order DRVI1)Yes
TTSCThrombin Time (Bovine), PYesYes
CLFIBFibrinogen, Clauss, PYes, (order FIBTP)Yes
DIMERD-Dimer, PYes, (order DDITT)Yes
ATTFAntithrombin Activity, PYesYes
CFXProtein C Activity, PYesYes
PSFProtein S Ag, Free, PYes, (order PSTF)Yes
APCRVActivated Protein Resistance V, PYesYes
PTNTProthrombin G20210A Mutation, BYesYes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
ATTIAntithrombin Antigen, PYesNo
FACTVCoag Factor V Assay, PYesNo
F_7Coag Factor VII Assay, PYesNo
F_9Coag Factor IX Assay, PYesNo
F_10Coag Factor X Assay, PYesNo
F_11Coag Factor XI Assay, PYesNo
F_12Coag Factor XII Assay, PYesNo
F8ACoag Factor VIII Activity Assay, PYesNo
RTSCReptilase Time, PYesNo
F_2Coag Factor II Assay, PYesNo
PCAGProtein C Ag, PYesNo
F5DNAFactor V Leiden (R506Q) Mutation, BYesNo
PNPPlatelet Neutralization ProcedureNoNo
PSTProtein S Ag, Total, PNoNo
STACLStaclot LA, PNoNo
DRV3DRVVT ConfirmationNoNo
S_FXProtein S Activity, PYesNo
SOLFMSoluble Fibrin MonomerNoNo
PTFIBPT-Fibrinogen, PNoNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

Initial testing includes: prothrombin time (PT); activated partial thromboplastin time (APTT); dilute Russell viper venom time (DRVVT); thrombin time (bovine); fibrinogen; D-dimer; antithrombin activity; protein C activity; protein S antigen, free; prothrombin G20210A mutation; activated protein resistance V; and thrombophilia interpretation.


If PT is >13.9 seconds, PT mix will be performed at an additional charge.


If APTT is > or =38 seconds, APTT mix will be performed at an additional charge.


If APTT mix is > or =38 seconds and thrombin time is <35.0 seconds (no evidence of heparin), platelet neutralization procedure will be performed at an additional charge.


If DRVVT ratio is > or =1.20, DRVVT mix and DRVVT confirmation will be performed at an additional charge.


If thrombin time is > or =25.0 seconds, reptilase time will be performed at an additional charge.


If fibrinogen is <150 mg/dL, or clinically indicated, PT-Fibrinogen will be performed at an additional charge.


If D-dimer is >500 ng/mL FEU, soluble fibrin monomer will be performed at an additional charge.


If protein S antigen, free is <65% for males and females > or =50 years of age and <50% for females <50 years of age, protein S antigen, total will be performed at an additional charge.


If protein C activity is <70% with no evidence for an acquired decrease in protein C activity, protein C antigen may be performed at an additional charge.


If antithrombin activity is <80% with no evidence of an acquired decrease in antithrombin activity, antithrombin antigen will be performed at an additional charge.


If activated protein C resistance (APC) ratio is <2.3 or baseline APC APTT is prolonged, factor V Leiden (R506Q) variant analysis will be performed at an additional charge.


If appropriate, protein S activity, coagulation factor assays, or Staclot LA will be performed at an additional charge to clarify significant abnormalities in the screen test results.


See Thrombophilia Profile in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

PTSC, APTSC, DRV1, TTSC, APCRV: Optical Clot-Based

CLFIB: Clauss

DIMER, PSF,: Latex Immunoassay (LIA)

ATTF, CFX: Chromogenic Assay

PTNT: Direct Mutation Analysis

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Thrombophilia Prof

Aliases Lists additional common names for a test, as an aid in searching

Thrombophilia Profile