Referred Tests
| Web: | mayocliniclabs.com |
|---|---|
| Email: | mcl@mayo.edu |
| Telephone: | 800-533-1710 |
| International: | +1 855-379-3115 |
| Values are valid only on day of printing. | |
Test ID: AATHR
Thrombophilia Profile, Plasma and Whole Blood
Useful For 
Suggests clinical disorders or settings where the test may be helpful
Evaluating patients with thrombosis or hypercoagulability states
Detecting a lupus-like anticoagulant; dysfibrinogenemia; disseminated intravascular coagulation/intravascular coagulation and fibrinolysis
Detecting a deficiency of antithrombin, protein C, or protein S
Detecting activated protein C resistance (and the factor V Leiden [p.Arg534Gln, historically known as R506Q] variant if indicated)
Detecting the prothrombin F2 c.*97G>A variant (historically known as G20210A)
Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| AATHI | Thrombophilia Interpretation | No | Yes |
| PTSC | Prothrombin Time (PT), P | Yes, (order PTTP) | Yes |
| APTSC | Activated Partial Thrombopl Time, P | Yes, (order APTTP) | Yes |
| DRV1 | Dilute Russells Viper Venom Time, P | Yes, (order DRVI1) | Yes |
| TTSC | Thrombin Time (Bovine), P | Yes | Yes |
| CLFIB | Fibrinogen, Clauss, P | Yes, (order FIBTP) | Yes |
| DIMER | D-Dimer, P | Yes, (order DDITT) | Yes |
| ATTF | Antithrombin Activity, P | Yes | Yes |
| CFX | Protein C Activity, P | Yes | Yes |
| PSF | Protein S Ag, Free, P | Yes, (order PSTF) | Yes |
| APCRV | Activated Protein Resistance V, P | Yes | Yes |
| PTNT | Prothrombin G20210A Mutation, B | Yes | Yes |
Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ATTI | Antithrombin Antigen, P | Yes | No |
| FACTV | Coag Factor V Assay, P | Yes | No |
| F_7 | Coag Factor VII Assay, P | Yes | No |
| F_9 | Coag Factor IX Assay, P | Yes | No |
| F_10 | Coag Factor X Assay, P | Yes | No |
| F_11 | Coag Factor XI Assay, P | Yes | No |
| F_12 | Coag Factor XII Assay, P | Yes | No |
| F8A | Coag Factor VIII Activity Assay, P | Yes | No |
| RTSC | Reptilase Time, P | Yes | No |
| F_2 | Coag Factor II Assay, P | Yes | No |
| PCAG | Protein C Ag, P | Yes | No |
| F5DNA | Factor V Leiden (R506Q) Mutation, B | Yes | No |
| PNP | Platelet Neutralization Procedure | No | No |
| PTMSC | PT Mix 1:1 | No | No |
| APMSC | APTT Mix 1:1 | No | No |
| PST | Protein S Ag, Total, P | No | No |
| STACL | Staclot LA, P | No | No |
| DRV2 | DRVVT Mix | No | No |
| DRV3 | DRVVT Confirmation | No | No |
| S_FX | Protein S Activity, P | Yes | No |
| SOLFM | Soluble Fibrin Monomer | No | No |
| PTFIB | PT-Fibrinogen, P | No | No |
Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
Initial testing includes: prothrombin time (PT); activated partial thromboplastin time (aPTT); dilute Russell viper venom time (dRVVT); thrombin time (bovine); fibrinogen; D-dimer; antithrombin activity; protein C activity; protein S antigen, free; prothrombin G20210A variant; activated protein resistance V; and thrombophilia interpretation.
If the PT is >13.9 seconds, then the PT mixing study will be performed at an additional charge.
If the aPTT is > or =38 seconds, then the aPTT mixing study will be performed at an additional charge.
If the aPTT mix result is > or =38 seconds and thrombin time is <35.0 seconds (no evidence of heparin), then the platelet neutralization procedure will be performed at an additional charge.
If the dRVVT ratio is > or =1.20, then the dRVVT mixing study and dRVVT confirmation will be performed at an additional charge.
If the thrombin time is > or =25.0 seconds, then the reptilase time will be performed at an additional charge.
If the fibrinogen result is <150 mg/dL or clinically indicated, then PT-fibrinogen will be performed at an additional charge.
If the D-dimer result is >500 ng/mL fibrinogen equivalent units (FEU), then soluble fibrin monomer testing will be performed at an additional charge.
If the free protein S antigen result is <65% for males and females > or =50 years of age and <50% for females <50 years of age, then the total protein S antigen test will be performed at an additional charge.
If the protein C activity is <70% with no evidence for an acquired decrease in protein C activity, then protein C antigen testing may be performed at an additional charge.
If the antithrombin activity is <80% with no evidence of an acquired decrease in antithrombin activity, then antithrombin antigen testing will be performed at an additional charge.
If the activated protein C resistance (APC) ratio is <2.3 or the baseline APC aPTT is prolonged, then factor V Leiden (R506Q) variant analysis will be performed at an additional charge.
If appropriate, protein S activity, coagulation factor assays, or Staclot LA will be performed at an additional charge to clarify significant abnormalities in the screen test results.
See Thrombophilia Profile in Special Instructions.
Special Instructions Library of PDFs including pertinent information and forms related to the test
Method Name A short description of the method used to perform the test
PTSC, APTSC, DRV1, TTSC, APCRV: Optical Clot-Based
CLFIB: Clauss
DIMER, PSF: Latex Immunoassay (LIA)
ATTF, CFX: Chromogenic Assay
PTNT: Direct Mutation Analysis
NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.
Reporting Name Lists a shorter or abbreviated version of the Published Name for a test
Aliases Lists additional common names for a test, as an aid in searching
Hypercoagulability
Thrombophilia Profile
Thrombosis
Clotting