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Test Catalog

Test ID: PAC1    
Paraneoplastic, Autoantibody Evaluation, Spinal Fluid

Useful For Suggests clinical disorders or settings where the test may be helpful

Aids in the diagnosis of paraneoplastic neurological autoimmune disorders related to carcinoma of lung, breast, ovary, thymoma, or Hodgkin lymphoma in spinal fluid specimens

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
PNEOIParaneoplastic Interpretation, CSFNoYes
AMPHCAmphiphysin Ab, CSFNoYes
AGN1CAnti-Glial Nuclear Ab, Type 1NoYes
ANN1CAnti-Neuronal Nuclear Ab, Type 1NoYes
ANN2CAnti-Neuronal Nuclear Ab, Type 2NoYes
ANN3CAnti-Neuronal Nuclear Ab, Type 3NoYes
CRMCCRMP-5-IgG, CSFNoYes
PCTRCPurkinje Cell Cytoplasmc Ab Type TrNoYes
PCA1CPurkinje Cell Cytoplasmic Ab Type 1NoYes
PCA2CPurkinje Cell Cytoplasmic Ab Type 2NoYes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
AMPCCAMPA-R Ab CBA, CSFNoNo
AMPICAMPA-R Ab IF Titer Assay, CSFNoNo
ABLTCAmphiphysin Western Blot, CSFNoNo
CS2CCCASPR2-IgG CBA, CSFNoNo
CRMWCCRMP-5-IgG Western Blot, CSFYesNo
DPPCCDPPX Ab CBA, CSFNoNo
DPPTCDPPX Ab IFA Titer, CSFNoNo
DPPICDPPX Ab IFA, CSFNoNo
GABCCGABA-B-R Ab CBA, CSFNoNo
GABICGABA-B-R Ab IF Titer Assay, CSFNoNo
GD65CGAD65 Ab Assay, CSFYesNo
LG1CCLGI1-IgG CBA, CSFNoNo
GL1CCmGluR1 Ab CBA, CSFNoNo
GL1TCmGluR1 Ab IFA Titer, CSFNoNo
GL1ICmGluR1 Ab IFA, CSFNoNo
NMDCCNMDA-R Ab CBA, CSFNoNo
NMDICNMDA-R Ab IF Titer Assay, CSFNoNo
WBNCParaneoplas Autoantibody WBlot,CSFNoNo
VGKCCVGKC-complex Ab IPA, CSFNoNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

If indirect immunofluorescence assay (IFA) (ANN1C, ANN2C, ANN3C, PCA1C, PCA2C, PCTRC, AMPHC, CRMC, AGN1C) is indeterminate, then paraneoplastic autoantibody Western blot is performed at an additional charge.

 

If IFA patterns suggest CRMP-5-IgG, then CRMP-5-IgG Western blot is performed at an additional charge.

 

If IFA patterns suggest GAD65 antibody, then GAD65 antibody radioimmunoassay is performed at an additional charge.

 

If IFA patterns suggest neuronal voltage-gated potassium channel-complex autoantibody, then VGKC-complex antibody IPA is performed at an additional charge.

 

If VGKCC is greater than 0.00 nmol/L, then LGI1-IgG cell-binding assay (CBA)and CASPR2-IgG CBA are performed at an additional charge.

 

If IFA patterns suggest amphiphysin antibody, then amphiphysin Western blot is performed at an additional charge.

 

If IFA pattern suggests NMDA-R, then NMDA-R antibody CBA and/or NMDA-R titer is performed at an additional charge.

 

If IFA pattern suggests AMPA-R, then AMPA-R antibody CBA and/or AMPA-R titer is performed at an additional charge.

 

If IFA pattern suggests GABA-B-R, then GABA-B-R antibody CBA and/or GABA-B-R titer is performed at an additional charge.

 

If IFA pattern suggests DPPX, then DPPX antibody CBA and DPPX titer is performed at an additional charge.

 

If IFA pattern suggests mGluR1, then mGluR1 antibody CBA and mGluR1 titer is performed at an additional charge.

 

The following algorithms are available in Special Instructions.

-Paraneoplastic Autoantibody CSF Evaluation Algorithm

-Hereditary Peripheral Neuropathy Diagnostic Algorithm

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

ANN1C, ANN2C, ANN3C, PCA1C, PCA2C, PCTRC, AMPHC, CRMC, AGN1C, NMDIC, AMPIC, GABIC, DPPIC, DPPTC, GL1IC, GL1TC: Indirect Immunofluorescence Assay (IFA)

WBNC, ABLTC, CRMWC: Western Blot

VGKCC: Radioimmunoassay (RIA)

DPPCC, NMDCC, AMPCC, GABCC, GL1CC, LG1CC, CS2CC: Cell-Binding Assay (CBA)

GD65C: Immunoprecipitation Assay (IPA)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Paraneoplas Autoantibody Eval,CSF

Aliases Lists additional common names for a test, as an aid in searching

Amphiphysin Ab, CSF
ANNA-1, CSF
ANNA-2, CSF
ANNA-3, CSF
Anti-Hu
Antineuronal
Cerebellar Antibodies
CRMP-5-IgG, CSF
Dorsal Root Ganglion Antibody
Hu Antibody
Neuron Restricted Autoantibodies
Neuronal Nuclear Antibody
Neuronal-Anti
Ovarian Cancer-Related Antibodies
Paraneoplastic Autoantibody Western Blot Confirmation, CSF
Paraneoplastic Neurological Autoimmunity
PCA-1, CSF
PCA-2, CSF
PCA-Tr, CSF
Purkinje Cell Cytoplasmic Antibodies
Ri, Anti
Yo-Anti