Test Catalog

Test ID: COGBL    
Chromosome Analysis, Hematologic Disorders, Children's Oncology Group Enrollment Testing, Blood

Useful For Suggests clinical disorders or settings where the test may be helpful

Evaluation of pediatric blood specimens for chromosomal abnormalities associated with hematologic malignancies for diagnostic and prognostic purposes in patients being considered for enrollment in Children’s Oncology Group clinical trials and research protocols


Cytogenetics testing is important for the diagnostic and prognostic classification of pediatric neoplasia and it is a critical element for enrollment of children into clinical trials affiliated with the Children's Oncology Group (COG). For over 25 years the Mayo Clinic Genomics Laboratory has served as one of a select number of laboratories in the United States approved by the COG for the conventional chromosome analysis and fluorescence in situ hybridization analysis of pediatric bone marrow, peripheral blood, and tissue specimens.


All enrollment-required elements of cytogenetics testing will be electronically submitted by the Mayo Clinic Genomics laboratory within the guidelines of COG.

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
ML20CCOG Metaphases, 1-19 No, (Bill Only)No
M25CCOG Metaphases, 20-25No, (Bill Only)No
MG25CCOG Metaphases, >25No, (Bill Only)No
_STACAg-Nor/CBL StainNo, (Bill Only)No

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This test is only performed on specimens from pediatric patients who are candidates for enrollment in Children's Oncology Group (COG) clinical trials and research protocols.


This test includes a charge for cell culture of fresh specimens and professional interpretation of results. Analysis charges will be incurred for total work performed, and generally include 2 banded karyograms and the analysis of 20 metaphase cells. If no metaphase cells are available for analysis, no analysis charges will be incurred. If additional analysis work is required, additional charges may be incurred.


-If this test is ordered and the laboratory is informed that the patient is not on a COG protocol, this test will be canceled and automatically reordered as CHRHB / Chromosome Analysis, Hematologic Disorders, Blood.

Method Name A short description of the method used to perform the test

Cell Culture without Mitogens followed by Chromosome Analysis

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

COG-Chromosomes, Hematologic, Blood

Aliases Lists additional common names for a test, as an aid in searching

Chromosome Analysis, Peripheral Blood Unstimulated
Hematologic Chromosome Analysis
Hematologic Karyotype
Karyotype, Peripheral Blood Unstimulated
Children's Oncology Group