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Test ID: T790M    
Cell-Free DNA EGFR T790M Mutation Analysis, Blood

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Useful For Suggests clinical disorders or settings where the test may be helpful

Determination of EGFR T790M mutation status in blood specimens as an alternative to invasive tissue biopsies

Identification of patients with non-small cell lung cancer who harbor a T790M mutation and may benefit from specific EGFR-targeted therapies

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

This test evaluates cell-free DNA (cfDNA) in the peripheral blood for the presence of the EGFR T790M mutation in patients with non-small cell lung cancer (NSCLC) and can be used to assess eligibility for targeted therapies. Current data suggests that patients with metastatic NSCLC and the T790M mutation may benefit from T790M-targeted therapy (eg, osimertinib).

 

This test is not validated for serial monitoring of patients with cancer. This test is also not intended as a screening test to identify cancer.

Highlights

Evaluates peripheral blood for the presence of the T790M mutation in the EGFR gene in cell-free DNA

 

Rapid detection of the EGFR T790M mutation in non-small cell lung cancer patients as an alternative for EGFR analysis of tissue

 

Current data suggests that patients with metastatic NSCLC and the T790M mutation may benefit from T790M-targeted therapy (eg, osimertinib)

Method Name A short description of the method used to perform the test

Digital Droplet Polymerase Chain Reaction (PCR) of Plasma Cell-Free DNA

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

cfDNA EGFR T790M Test, Blood

Aliases Lists additional common names for a test, as an aid in searching

NSCLC
Non-small cell lung cancer
Lung cancer
EGFR
Epidermal growth factor receptor
Cell free DNA
cfDNA
Circulating tumor DNA
Liquid biopsy
Circulating tumor cells
T790M
Cell-free DNA